Selected Publications

Link to other NIH Publications

(*) Indicates Corresponding author

Hu, J., Pauer, G.J., Hagstrom, S.A., Bok, D., DeBenedictis, M.J., Bonilha, V., Hollyfield, J.G., and Radu, R.A.*: Evidence of Complement Dysregulation in Outer Retina of Stargardt Disease Donor Eyes. Redox Biology 2020; 37:101787.
PMID: 33214125  PMCID: PMC7767765  DOI: 10.1016/j.redox.2020.101787

Bonilha, V.L., Bell, B.A., Hu, J., Milliner, C., Pauer, G.J., Hagstrom, S.A., Radu, R.A., and Hollyfield, J.G: Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lessions. Invest. Ophthalmol. Vis. Sci. 2020; 5 Jul 1;61(8):15.
PMID: 32658960  PMCID: PMC7425718  DOI: 10.1167/iovs.61.8.15

Fang, Y., Tschulakow, A., Taubitz, T., Illing, B., Biesemeier, A., Julien-Schraermeyer, S., Jiang, Z., Radu, R.A., and Schraermeyer U: Fundus autofluorescence, spectral-domain optical coherence tomography, and histology correlations in Stargardt disease mouse model.  FASEB J. 2020 Mar;34(3):3693-3714. Epub 2020 Jan 27. 
PMID: 31989709   DOI: 10.1096/fj.201901784RR. 

Morshedian, A., Kaylor, J.J., Ng, S.Y., Tsan, A., Frederiksen, R., Xu, T., Yuan, L., Sampath, A.P., Radu, R.A., Fain, G.L., Travis, G.H: Light-driven regeneration of cone visual pigments through a mechanism involving RGR opsin in Müller glial cells.  Neuron 2019; 102(6): 1172-1180
PMID: 31056353  PMCID: PMC6586478  DOI: 10.1016/j.neuron.2019.04.004

Lenis, T.L., Hu, J., Ng, S.Y., Jiang, Z., Sarfare, S., Lloyd, M.B., Esposito, N., Samuel, W., Jaworski, C., Bok, D., Finnemann, S., Radeke, M., Redmond, T.M., Travis, G.H., and Radu, R.A.*: Expression of ABCA4 in Retinal Pigment Epithelium and its implications for Stargardt disease. – Proc. Natl. Acad. Sci. USA. 2018; 115(47):E11120-E11127
PMID: 30397118  PMCID: PMC6255167   DOI: 10.1073/pnas.1802519115

McClements, M.E., Barnard, A.R., Singh, M.S., Charbel Issa, P., Jiang, Z., Radu, R.A., and MacLaren, R.E: An AAV dual vector strategy ameliorates the Stargardt phenotype in adult ABCA4-/- mice.  Human gene therapy. 2018; 30(5): 590-600
PMID: 30381971  PMCID: PMC6909730  DOI: 10.1089/hum.2018.156

Cook, J.D., Ng, S.Y., Lloyd, M., Eddington, S., Sun H., Nathans, J., Bok, D., Radu, R.A., and Travis, G.H:  Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium. J. Biol. Chem. 2018; 292(52):21407-21416
PMID: 29109151  PMCID: PMC5766940  DOI: 10.1074/jbc.M117.812701

Lenis, T.L., Sarfare, S., Jiang, Z., Lloyd, M.B., Bok, D., and Radu, R.A.*: Complement Modulation in the Retinal Pigment Epithelium Rescues Photoreceptor Degeneration in a Mouse Model of Stargardt Disease.  Proc. Natl. Acad. Sci. USA. 2017; 114(15):3987-3992 PMID: 28348233  PMCID: PMC5393232   DOI: 10.1073/pnas.1620299114

Kaylor, J.J., Radu, R.A., Bischoff, N., Makshanoff, J., Hu, J., Lloyd, M., Eddington, S., Bianconi, T., Bok, D., Travis, G.H: Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium. PLoS One. 2015; 10(5):1-14 PMID: 25974161  PMCID: PMC4431840   DOI: 10.1371/journal.pone.0125921

Smit-McBride, Z., Oltjen, S.L., Radu, R.A., Estep, J., Nguyen, A.T., Gong, Q., and Hjelmeland, L.M: Localization of complement factor H gene expression and protein distribution in the mouse outer retina. Molec. Vis. 2015; 21:110-123
PMID: 25684976  PMCID: PMC4323684

Radu, R.A.*, Hu, J., Jiang, Z., and Bok, D: Bisretinoid-mediated Complement Activation on Retinal Pigment Epithelial Cells is Dependent on Complement Factor H Haplotype. J. Biol. Chem. 2014; 289: 9113-9120
PMID: 21464132  PMCID: PMC3099675   DOI: 10.1074/jbc.M110.191866

Charbel Issa, P., Barnard, R.A., Singh, M., Carter, E., Jiang, Z., Radu, R.A., Schraermeyer, U., and MacLaren, R.A: Fundus Autofluorescence in the Abca4-/- Mouse Model of Stargardt Disease - Correlation with Accumulation of A2E, Retinal Function and Histology. Invest. Ophthalmol. Vis. Sci. 2013; 54(8):5602-12
PMID: 23761084  PMCID: PMC3747716  DOI: 10.1167/iovs.13-11688

Mullins, R.F., Kuehn, M.H., Radu, R.A., Enriquez, S., East, J.S., Schindler, E.I., Travis, G.H., Stone, E.M: Autosomal recessive pigmentosa due to ABCA4 mutations: Clinical, pathological and molecular characterization. Invest. Ophthalmol. Vis. Sci. 2012; 53(4):1883-94
PMID: 22395892 PMCID: PMC3995570   DOI: 10.1167/iovs.12-9477

Radu, R.A.*, Hu, J., Yuan, Q., Welch, D.L., Makshanoff, J., Lloyd, M., McMullen, S., Travis, G.H., and Bok, D: Complement System Dysregulation and Inflammation in the Retinal Pigment Epithelium of a Mouse Model for Stargardt Macular Degeneration.  J. Biol. Chem. 2011; 286(21): 18593-18601
PMID: 21464132  PMCID: PMC3099675  DOI: 10.1074/jbc.M110.191866

Radu, R.A., Yuan, Q., Hu, J., Peng, J.H., Lloyd, M., Nusinowitz, S. Bok, D., Travis, G.H: Vitamin A Accelerated Accumulation of Lipofuscin Pigments in the RPE of a Mouse Model for ABCA4-mediated Retinal Dystrophies Following Vitamin A Supplementation. Invest. Ophthalmol. Vis. Sci. 2008; 49(9), 3821-3829
PMID: 18515570  PMCID: PMC2851626  DOI: 10.1167/iovs.07-1470

Radu, R.A., Hu, J., Peng, J.H., Bok, D., Mata, N.L., Travis, G.H: Retinal Pigment Epithelium-retinal G Protein Receptor-Opsin Mediates Light-dependent Translocation of all-trans-retinyl Esters for Synthesis of Visual Chromophore in Retinal Pigment Epithelial Cells. J. Biol. Chem. 2008; 283(28), 19730-19730
PMID: 18474598  PMCID: PMC2443657   DOI: 10.1074/jbc.M801288200

Bakall, B., Radu, R.A., Stanton, J.B., Burke, J.M., McKay, B.S., Wadelius, C., Mullins, R.F., Stone, E.M., Travis, G.H., Marmorstein, A.D: Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2).  Exp. Eye Res. 2007; 85, 34-43
PMID: 17477921  DOI: 10.1016/j.exer.2007.02.018

Radu, R.A., Han, Y., Bui, T.V., Nusinowitz, S., Bok, D., Lichter, J., Widder, K., Travis, G.H., Mata, N.L. Reductions in Serum Vitamin A Arrest Accumulation of Toxic Retinal Fluorophores: A Potential Therapy for Treatment of Lipofuscin-based Retinal Diseases.  Invest. Ophthalmol. Vis. Sci. 2005; 46, 4393-4401.
PMID: 16303925  DOI: 10.1167/iovs.05-0820

Mata, N.L., Ruiz, A., Radu, R.A., Bui, T.V., Travis, G.H. Chicken Retinas Contain a Retinoid Isomerase Activity that Catalyzes the Direct Conversion of all-trans-retinol to 11-cis-retinol.  Biochemistry. 2005; 44, 11715-11721 PMID: 16128572.
PMID: 16128572 PMCID: PMC2851629                   DOI: 10.1021/bi050942m

Radu, R.A., Mata, N.L., Bagla, A., and Travis, G.H. Light Exposure Stimulates Formation of A2E Oxirane in a Mouse Model of Stargardt's Macular Degeneration.  Proc. Natl. Acad. Sci. USA. 2004; 101, 5928-5933; PMCID:PMC395900.
PMID: 15067110         PMCID: PMC395900              DOI: 10.1073/pnas.0308302101

Radu, R.A., Mata, N.L., Nusinowitz, S., Liu, X., Sieving, P.A., and Travis, G.H. Treatment with Isotretinoin Inhibits Lipofuscin Accumulation in a Mouse Model of Recessive Stargardt's Macular Degeneration.  Proc. Natl. Acad. Sci. USA. 2003; 100, 4742-4747
PMID: 12671074         PMCID: PMC153626              DOI: 10.1073/pnas.0737855100

Mata, N.L., Radu, R.A., Clemmons, R.S., and Travis, G.H. Isomerization and Oxidation of Vitamin A in Cone-dominant retinas: Evidence for a New Pathway that Mediates Regeneration of Visual Pigments in Daylight.  Neuron. 2002; 36, 69-80
PMID: 12367507         PMCID: PMC2851622            DOI: 10.1016/s0896-6273(02)00912-1