Faculty Publications (A - L)

Note: Publications listed are 2012-Present (updated quarterly). Please click on PubMed links for earlier publications.

B C D E F G H I J K L

Baum, Linda, MD, PhD

The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy. Marshall JL, Kwok Y, McMorran BJ, Baum LG, Crosbie-Watson RH. FEBS J. 2013 Sep;280(17):4210-29. doi: 10.1111/febs.12295. Epub 2013 May 13. Review. View abstract here

Introduction to special issue: Sugars, bugs and us. Baum LG, Braun J. Glycobiology. 2013 Sep;23(9):1025. doi: 10.1093/glycob/cwt047. Epub 2013 Jun 10. No abstract available. View abstract here

VEGFR1 and VEGFR2 involvement in extracellular galectin-1- and galectin-3-induced angiogenesis. D'Haene N, Sauvage S, Maris C, Adanja I, Le Mercier M, Decaestecker C, Baum L, Salmon I. PLoS One. 2013 Jun 17;8(6):e67029. doi: 10.1371/journal.pone.0067029. Print 2013. View abstract here

Galectin-3 binds to CD45 on diffuse large B-cell lymphoma cells to regulate susceptibility to cell death. Clark MC, Pang M, Hsu DK, Liu FT, de Vos S, Gascoyne RD, Said J, Baum LG. Blood. 2012 Nov 29;120(23):4635-44. doi: 10.1182/blood-2012-06-438234. Epub 2012 Oct 12. View abstract here

High throughput screening for compounds that alter muscle cell glycosylation identifies new role for N-glycans in regulating sarcolemmal protein abundance and laminin binding. Cabrera PV, Pang M, Marshall JL, Kung R, Nelson SF, Stalnaker SH, Wells L, Crosbie-Watson RH, Baum LG. J Biol Chem. 2012 Jun 29;287(27):22759-70. doi: 10.1074/jbc.M111.334581. Epub 2012 May 8. View abstract here

T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival. Clark MC, Baum LG. Ann N Y Acad Sci. 2012 Apr;1253:58-67. doi: 10.1111/j.1749-6632.2011.06304.x. Epub 2012 Jan 30. View abstract here

PubMed: Linda Baum


Bensinger, Steven, VMD, PhD

Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus. Kidani Y, Bensinger SJ. J Clin Invest. 2014 Feb 3;124(2):482-5. doi: 10.1172/JCI74141. Epub 2014 Jan 27.

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. Nat Immunol. 2013 Oct;14(10):1073-83. doi: 10.1038/ni.2707. Epub 2013 Sep 8. View abstract here

Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth. York AG, Bensinger SJ. J Exp Med. 2013 Aug 26;210(9):1653-6. doi: 10.1084/jem.20131335. View abstract here

Immunology. Fueling function over expansion in T cells. Argus JP, Bensinger SJ. Science. 2013 Jul 5;341(6141):37-8. doi: 10.1126/science.1242100. View abstract here

Doxycycline alters metabolism and proliferation of human cell lines. Ahler E, Sullivan WJ, Cass A, Braas D, York AG, Bensinger SJ, Graeber TG, Christofk HR. PLoS One. 2013 May 31;8(5):e64561. doi: 10.1371/journal.pone.0064561. View abstract here

Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF, Graeber TG, Reue K, Brooks DG, Bensinger SJ. Nat Immunol. 2013 Apr 7. doi: 10.1038/ni.2570. View abstract here

De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS. Cancer Discov. 2013 Mar 27. View abstract here

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger S. Cancer Res. 2013 Feb 25. View abstract here

Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity. Kidani Y, Bensinger SJ. Immunol Rev. 2012 Sep;249(1):72-83. doi: 10.1111/j.1600-065X.2012.01153.x. View abstract here

Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection. Wilson EB, Kidani Y, Elsaesser H, Barnard J, Raff L, Karp CL, Bensinger S, Brooks DG. Cell Host Microbe. 2012 May 17;11(5):481-91. doi: 10.1016/j.chom.2012.03.009. View abstract here

New aspects of the Warburg effect in cancer cell biology. Bensinger SJ, Christofk HR. Semin Cell Dev Biol. 2012 Jun;23(4):352-61. doi: 10.1016/j.semcdb.2012.02.003. Epub 2012 Mar 8. View abstract here

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. J Clin Invest. 2012 Jan 3;122(1):337-47. doi: 10.1172/JCI58393. Epub 2011 Dec 12. View abstract here

PubMed: Steven Bensinger

 


Bhuta, Sunita, MD

Sinonasal lymphoma: case series and review of the literature. Peng KA, Kita AE, Suh JD, Bhuta SM, Wang MB. Int Forum Allergy Rhinol. 2014 Apr 23. doi: 10.1002/alr.21337. [Epub ahead of print]

Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients. Lagadec C, Vlashi E, Bhuta S, Lai C, Mischel P, Werner M, Henke M, Pajonk F. BMC Cancer. 2014 Mar 5;14:152. doi: 10.1186/1471-2407-14-152.

A pregnant dilemma: primary hyperparathyroidism due to parathyromatosis in pregnancy. Edling KL, Korenman SG, Janzen C, Sohsman MY, Apple SK, Bhuta S, Yeh MW. Endocr Pract. 2014 Feb;20(2):e14-7. doi: 10.4158/EP13105.CR.

Infarction of papillary thyroid carcinoma after fine-needle aspiration: case series and review of literature. Liu YF, Ahmed S, Bhuta S, Sercarz JA. JAMA Otolaryngol Head Neck Surg. 2014 Jan;140(1):52-7. doi: 10.1001/jamaoto.2013.5650. Review.

COX-(2) overexpression in sinonasal inverted papilloma. Suh JD, Palma-Diaz F, Bhuta S, Wang MB. Int Forum Allergy Rhinol. 2013 Dec;3(12):997-1000. doi: 10.1002/alr.21218. Epub 2013 Sep 16.

Metastatic disease to the clivus mimicking clival chordomas. Deconde AS, Sanaiha Y, Suh JD, Bhuta S, Bergsneider M, Wang MB. J Neurol Surg B Skull Base. 2013 Oct;74(5):292-9. doi: 10.1055/s-0033-1348027. Epub 2013 Jun 26.

Solitary fibrous tumor of the hypopharynx: Case report and literature review. Thompson CF, Bhuta SM, Abemayor E. Am J Otolaryngol. 2013 Sep-Oct;34(5):545-7. doi: 10.1016/j.amjoto.2013.03.005. Epub 2013 Apr 6. View abstract here

A unique case of sclerosing polycystic adenosis of the sinonasal tract. Su A, Bhuta SM, Berke GS, Lai CK. Hum Pathol. 2013 Sep;44(9):1937-40. doi: 10.1016/j.humpath.2013.01.017. Epub 2013 Mar 1. View abstract here

Schneiderian papillomas: comparative review of exophytic, oncocytic, and inverted types. Vorasubin N, Vira D, Suh JD, Bhuta S, Wang MB. Am J Rhinol Allergy. 2013 Jul-Aug;27(4):287-92. doi: 10.2500/ajra.2013.27.3904. View abstract here

A Novel Exonic Splicing Mutation in the TAZ (G4.5) Gene in a Case with Atypical Barth Syndrome. Fan Y, Steller J, Gonzalez IL, Kulik W, Fox M, Chang R, Westerfield BA, Batra AS, Wang RY, Gallant NM, Pena LS, Wang H, Huang T, Bhuta S, Penny DJ, McCabe ER, Kimonis VE. JIMD Rep. 2013 Apr 19. View abstract here

Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis. Liu N, Tai S, Ding B, Thor RK, Bhuta S, Sun Y, Huang J. Endocr Relat Cancer. 2012 Sep 21;19(5):711-23. doi: 10.1530/ERC-12-0150. Print 2012 Oct. View abstract here

Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells. Tai S, Sun Y, Liu N, Ding B, Hsia E, Bhuta S, Thor RK, Damoiseaux R, Liang C, Huang J. Mol Cancer Ther. 2012 Jun;11(6):1320-31. doi: 10.1158/1535-7163.MCT-11-0954. Epub 2012 Apr 5. View abstract here

PubMed: Sunita Bhuta

 


Cochran, Alistair, MD

Should Patients Being Considered for Surgical Management in Melanoma Centers Have Their Histology Reviewed by Specialized Pathologists? Cochran AJ. Ann Surg Oncol. 2014 Apr 14. [Epub ahead of print] No abstract available.

Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma. Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z, Auerbach M, Ng C, Avramis E, Seja E, Villanueva A, McCannel TA, Ishiyama A, Czernin J, Radu CG, Wang X, Gjertson DW, Cochran AJ, Cornetta K, Wong DJ, Kaplan-Lefko P, Hamid O, Samlowski W, Cohen PA, Daniels GA, Mukherji B, Yang L, Zack JA, Kohn DB, Heath JR, Glaspy JA, Witte ON, Baltimore D, Economou JS, Ribas A. Clin Cancer Res. 2014 Apr 9. [Epub ahead of print]

CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire. Robert L, Tsoi J, Wang X, Emerson R, Homet B, Chodon T, Mok S, Huang RR, Cochran AJ, Comin-Anduix B, Koya RC, Graeber TG, Robins H, Ribas A. Clin Cancer Res. 2014 Apr 9.

Age as a predictor of sentinel node metastasis among patients with localized melanoma: an inverse correlation of melanoma mortality and incidence of sentinel node metastasis among young and old patients. Balch CM, Thompson JF, Gershenwald JE, Soong SJ, Ding S, McMasters KM, Coit DG, Eggermont AM, Gimotty PA, Johnson TM, Kirkwood JM, Leong SP, Ross MI, Byrd DR, Cochran AJ, Mihm MC Jr, Morton DL, Atkins MB, Flaherty KT, Sondak VK. Ann Surg Oncol. 2014 Apr;21(4):1075-81. doi: 10.1245/s10434-013-3464-x. Epub 2014 Feb 15.

Histomorphologic Assessment and Interobserver Diagnostic Reproducibility of Atypical Spitzoid Melanocytic Neoplasms With Long-term Follow-up. Gerami P, Busam K, Cochran A, Cook MG, Duncan LM, Elder DE, Fullen DR, Guitart J, Leboit PE, Mihm MC Jr, Prieto VG, Rabkin MS, Scolyer RA, Xu X, Yun SJ, Obregon R, Yazdan P, Cooper C, Weitner BB, Rademaker A, Barnhill RL. Am J Surg Pathol. 2014 Mar 10.

A Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trialof Lovastatin for Various Endpoints of Melanoma Pathobiology. Linden KG, Leachman SA, Zager JS, Jakowatz JG, Viner JL, McLaren CE, Barr RJ, Carpenter PM, Chen WP, Elmets CA, Tangrea J, Lim SJ, Cochran AJ, Meyskens FL. Cancer Prev Res (Phila). 2014 Mar 10.

COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors. Escuin-Ordinas H, Atefi M, Fu Y, Cass A, Ng C, Huang RR, Yashar S, Comin-Anduix B, Avramis E, Cochran AJ, Marais R, Lo RS, Graeber TG, Herschman HR, Ribas A. Mol Oncol. 2014 Mar;8(2):250-60. doi: 10.1016/j.molonc.2013.11.005. Epub 2013 Dec 1.

Final trial report of sentinel-node biopsy versus nodal observation in melanoma. Morton DL, Thompson JF, Cochran AJ, Mozzillo N, Nieweg OE, Roses DF, Hoekstra HJ, Karakousis CP, Puleo CA, Coventry BJ, Kashani-Sabet M, Smithers BM, Paul E, Kraybill WG, McKinnon JG, Wang HJ, Elashoff R, Faries MB; MSLT Group. N Engl J Med. 2014 Feb 13;370(7):599-609. doi: 10.1056/NEJMoa1310460.

Age as a prognostic factor in patients with localized melanoma and regional metastases. Balch CM, Soong SJ, Gershenwald JE, Thompson JF, Coit DG, Atkins MB, Ding S, Cochran AJ, Eggermont AM, Flaherty KT, Gimotty PA, Johnson TM, Kirkwood JM, Leong SP, McMasters KM, Mihm MC Jr, Morton DL, Ross MI, Sondak VK. Ann Surg Oncol. 2013 Nov;20(12):3961-8. doi: 10.1245/s10434-013-3100-9. Epub 2013 Jul 10.

Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy. Ma C, Cheung AF, Chodon T, Koya RC, Wu Z, Ng C, Avramis E, Cochran AJ, Witte ON, Baltimore D, Chmielowski B, Economou JS, Comin-Anduix B, Ribas A, Heath JR. Cancer Discov. 2013 Apr;3(4):418-29. doi: 10.1158/2159-8290.CD-12-0383. Epub 2013 Mar 21.

Pilot study on "pericytic mimicry" and potential embryonic/stem cell properties of angiotropic melanoma cells interacting with the abluminal vascular surface. Lugassy C, Wadehra M, Li X, Corselli M, Akhavan D, Binder SW, Péault B, Cochran AJ, Mischel PS, Kleinman HK, Barnhill RL. Cancer Microenviron. 2013 Apr;6(1):19-29. doi: 10.1007/s12307-012-0128-5. Epub 2012 Dec 29. View abstract here

Differential gene expression profiling of primary cutaneous melanoma and sentinel lymph node metastases. Koh SS, Wei JP, Li X, Huang RR, Doan NB, Scolyer RA, Cochran AJ, Binder SW. Mod Pathol. 2012 Jun;25(6):828-37. doi: 10.1038/modpathol.2012.32. Epub 2012 Mar 9. View abstract here

PubMed: Alistair Cochran


Crooks, Gay, MBBS

Dynamics of HSPC Repopulation in Nonhuman Primates Revealed by a Decade-Long Clonal-Tracking Study. Kim S, Kim N, Presson AP, Metzger ME, Bonifacino AC, Sehl M, Chow SA, Crooks GM, Dunbar CE, An DS, Donahue RE, Chen IS. Cell Stem Cell. 2014 Apr 3;14(4):473-85. doi: 10.1016/j.stem.2013.12.012.

Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. Kim WS, Zhu Y, Deng Q, Chin CJ, He CB, Grieco AJ, Dravid GG, Parekh C, Hollis RP, Lane TF, Bouhassira EE, Kohn DB, Crooks GM. Stem Cells. 2014 Feb 14. doi: 10.1002/stem.1677.

Lysophosphatidic Acid Mediates Myeloid Differentiation within the Human Bone Marrow Microenvironment. Evseenko D, Latour B, Richardson W, Corselli M, Sahaghian A, Cardinal S, Zhu Y, Chan R, Dunn B, Crooks GM. PLoS One. 2013 May 16;8(5):e63718. doi: 10.1371/journal.pone.0063718. View abstract here

Perivascular support of human hematopoietic cells. Corselli M, Chin CJ, Parekh C, Sahaghian A, Wang W, Ge S, Evseenko D, Wang X, Montelatici E, Lazzari L, Crooks GM, Péault B. Blood. 2013 Feb 14. View abstract here

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Hsieh YT, Gang EJ, Geng H, Park E, Huantes S, Chudziak D, Dauber K, Schaefer P, Scharman C, Shimada H, Shojaee S, Klemm L, Parameswaran R, Loh M, Kang ES, Koo HH, Hoffman WK, Andrade J, Crooks GM, Willman CL, Müschen M, Papayannopoulou T, Heisterkamp N, Bönig H, Kim YM. Blood. 2013 Jan 14. View abstract here

Critical Differences in Hematopoiesis and Lymphoid Development between Humans and Mice. Parekh C, Crooks GM. J Clin Immunol. 2012 Dec 30. View abstract here

Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR. PLoS One. 2012;7(10):e45603. doi: 10.1371/journal.pone.0045603. Epub 2012 Oct 9. View abstract here

Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. Candotti F, Shaw KL, Muul L, Carbonaro D, Sokolic R, Choi C, Schurman SH, Garabedian E, Kesserwan C, Jagadeesh GJ, Fu PY, Gschweng E, Cooper A, Tisdale JF, Weinberg KI, Crooks GM, Kapoor N, Shah A, Abdel-Azim H, Yu XJ, Smogorzewska M, Wayne AS, Rosenblatt HM, Davis CM, Hanson C, Rishi RG, Wang X, Gjertson D, Yang OO, Balamurugan A, Bauer G, Ireland JA, Engel BC, Podsakoff GM, Hershfield MS, Blaese RM, Parkman R, Kohn DB. Blood. 2012 Nov 1;120(18):3635-46. doi: 10.1182/blood-2012-02-400937. Epub 2012 Sep 11. View abstract here

Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. Kohn LA, Hao QL, Sasidharan R, Parekh C, Ge S, Zhu Y, Mikkola HK, Crooks GM. Nat Immunol. 2012 Oct;13(10):963-71. doi: 10.1038/ni.2405. Epub 2012 Sep 2. View abstract here

Novel pathways to erythropoiesis induced by dimerization of intracellular C-Mpl in human hematopoietic progenitors. Parekh C, Sahaghian A, Kim W, Scholes J, Ge S, Zhu Y, Asgharzadeh S, Hollis R, Kohn D, Ji L, Malvar J, Wang X, Crooks G. Stem Cells. 2012 Apr;30(4):697-708. doi: 10.1002/stem.1046. View abstract here

Rapid thymic reconstitution following bone marrow transplantation in neonatal mice is VEGF-dependent. Cuddihy AR, Suterwala BT, Ge S, Kohn LA, Jang J, Andrade J, Wang X, Crooks GM. Biol Blood Marrow Transplant. 2012 May;18(5):683-9. doi: 10.1016/j.bbmt.2012.01.006. Epub 2012 Jan 25. View abstract here

PubMed: Gay Crooks


Dawson, David, MD, PhD

The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. von Figura G, Fukuda A, Roy N, Liku ME, Morris Iv JP, Kim GE, Russ HA, Firpo MA, Mulvihill SJ, Dawson DW, Ferrer J, Mueller WF, Busch A, Hertel KJ, Hebrok M. Nat Cell Biol. 2014 Mar;16(3):255-67. doi: 10.1038/ncb2916. Epub 2014 Feb 23.

Locally advanced pancreatic cancer: association between prolonged preoperative treatment and lymph-node negativity and overall survival. Kadera BE, Sunjaya DB, Isacoff WH, Li L, Hines OJ, Tomlinson JS, Dawson DW, Rochefort MM, Donald GW, Clerkin BM, Reber HA, Donahue TR. JAMA Surg. 2014 Feb;149(2):145-53. doi: 10.1001/jamasurg.2013.2690.

Nonfunctional Pancreatic Neuroendocrine Tumors View abstract here

High-Fat, High-Calorie Diet Promotes Early Pancreatic Neoplasia in the Conditional KrasG12D Mouse Model. Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G. Cancer Prev Res (Phila). 2013 Oct;6(10):1064-1073. Epub 2013 Aug 13. View abstract here

Response to Comments on: Butler et al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595-2604. Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. Diabetes. 2013 Oct;62(10):e19-22. doi: 10.2337/db13-0996. View abstract here

MicroRNA-21 in Pancreatic Ductal Adenocarcinoma Tumor-Associated Fibroblasts Promotes Metastasis. Kadera BE, Li L, Toste PA, Wu N, Adams C, Dawson DW, Donahue TR. PLoS One. 2013 Aug 22;8(8):e71978. doi: 10.1371/journal.pone.0071978. View abstract here

Endoscopically Acquired Pancreatic Cyst Fluid MicroRNA 21 and 221 Are Associated With Invasive Cancer. Farrell JJ, Toste P, Wu N, Li L, Wong J, Malkhassian D, Tran LM, Wu X, Li X, Dawson D, Wu H, Donahue TR. Am J Gastroenterol. 2013 Jun 11. doi: 10.1038/ajg.2013.167. View abstract here

The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom. Zimbarra Cabrita I, Mohammed A, Layton M, Ghorashian S, Gilmore A, Cho G, Howard J, Anie KA, Desforges L, Bassett P, Grapsa J, Howard L, Mahalingam G, Dawson D, Pinto FJ, Nihoyannopoulos P, Davies SC, Gibbs JS. Br J Haematol. 2013 May 29. doi: 10.1111/bjh.12391. View abstract here

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, Vandenberg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J and Karin M. (2013) J. Clin. Invest. 123:2231-43. PMID:23563314 View abstract here

Marked Expansion of Exocrine and Endocrine Pancreas with Incretin Therapy in Humans with increased Exocrine Pancreas Dysplasia and the potential for Glucagon-producing Neuroendocrine Tumors. Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. Diabetes. 2013 Mar 22. View abstract here

Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Mann KM, Ward JM, Yew CC, Kovochich A, Dawson DW, Black MA, Brett BT, Sheetz TE, Dupuy AJ; Australian Pancreatic Cancer Genome Initiative, Chang DK, Biankin AV, Waddell N, Kassahn KS, Grimmond SM, Rust AG, Adams DJ, Jenkins NA, Copeland NG.
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5934-41. doi: 10.1073/pnas.1202490109. Epub 2012 Mar 15 View abstract here

HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma. Nguyen Kovochich A, Arensman M, Lay AR, Rao NP, Donahue T, Li X, French SW, Dawson DW. Cancer. 2013 Feb 1;119(3):529-39. doi: 10.1002/cncr.27725. Epub 2012 Aug 22. View abstract here

SAMe treatment prevents the ethanol-induced epigenetic alterations of genes in the Toll-like receptor pathway. Khachatoorian R, Dawson D, Maloney EM, Wang J, French BA, French SW, French SW. Exp Mol Pathol. 2013 Feb;94(1):243-6. doi: 10.1016/j.yexmp.2012.09.024. Epub 2012 Oct 6. View abstract here

Diagnosis of dysplasia in upper gastro-intestinal tract through digital microscopy. Gui D, Cortina G, Naini B, Hart S, Gerney G, Dawson D and Dry S. (2012) J. Pathol. Inform. 3:27. PMID:23024886

Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell. Pandol S, Gukovskaya A, Edderkoui M, Dawson D, Eibl G and Lugea A. (2012) J. Gastroenterol. Hepatol. Suppl 2:127-34. PMID:22320930

Negative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5. Zhou G, Liu SH, Shahi KM, Wang H, Duan X, Lin X, Feng XH, Li M, Fisher WE, Demayo FJ, Dawson D, Brunicardi FC. Mol Endocrinol. 2012 Jul;26(7):1225-34. doi: 10.1210/me.2012-1095. Epub 2012 Jun 5. View abstract here

Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM, Butler PC. Diabetes. 2012 May;61(5):1250-62. doi: 10.2337/db11-1109. Epub 2012 Jan 20. Erratum in: Diabetes. 2012 Aug;61(8):2195. View abstract here

Integrative survival-based molecular profiling of human pancreatic cancer. Donahue TR, Tran LM, Hill R, Li Y, Kovochich A, Calvopina JH, Patel SG, Wu N, Hindoyan A, Farrell JJ, Li X, Dawson DW, Wu H. Clin Cancer Res. 2012 Mar 1;18(5):1352-63. doi: 10.1158/1078-0432.CCR-11-1539. Epub 2012 Jan 18. View abstract here

Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. Biechele TL, Kulikauskas RM, Toroni RA, Lucero OM, Swift RD, James RG, Robin NC, Dawson DW, Moon RT, Chien AJ. Sci Signal. 2012 Jan 10;5(206):ra3. doi: 10.1126/scisignal.2002274. View abstract here

Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein. Camp ND, James RG, Dawson DW, Yan F, Davison JM, Houck SA, Tang X, Zheng N, Major MB, Moon RT. J Biol Chem. 2012 Feb 24;287(9):6539-50. doi: 10.1074/jbc.M111.316471. Epub 2012 Jan 3. View abstract here

Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. White BD, Chien AJ, Dawson DW.Gastroenterology. 2012 Feb;142(2):219-32. doi: 10.1053/j.gastro.2011.12.001. Epub 2011 Dec 8. Review. View abstract here

PubMed: David Dawson


Deignan, Joshua, PhD, FACMG

Molecular pathology curriculum for medical laboratory scientists: a report of the association for molecular pathology training and education committee. Taylor S, Bennett KM, Deignan JL, Hendrix EC, Orton SM, Verma S, Schutzbank TE. J Mol Diagn. 2014 May;16(3):288-96. doi: 10.1016/j.jmoldx.2014.02.003.

Assessing the necessity of confirmatory testing for exome-sequencing results in a clinical molecular diagnostic laboratory. Strom SP, Lee H, Das K, Vilain E, Nelson SF, Grody WW, Deignan JL. Genet Med. 2014 Jan 9. doi: 10.1038/gim.2013.183. [Epub ahead of print]

ACMG clinical laboratory standards for next-generation sequencing. Rehm HL, Bale SJ, Bayrak-Toydemir P, Berg JS, Brown KK, Deignan JL, Friez MJ, Funke BH, Hegde MR, Lyon E; Working Group of the American College of Medical Genetics and Genomics Laboratory Quality Assurance Commitee. Genet Med. 2013 Sep;15(9):733-47. doi: 10.1038/gim.2013.92. Epub 2013 Jul 25.

Deaf Genetic Testing and Psychological Well-Being in Deaf Adults. Palmer CG, Boudreault P, Baldwin EE, Fox M, Deignan JL, Kobayashi Y, Sininger Y, Grody W, Sinsheimer JS. J Genet Couns. 2013 Feb 21. [Epub ahead of print] View abstract here

Biochemical, molecular, and clinical characteristics of children with short chain acyl-CoA dehydrogenase deficiency detected by newborn screening in California. Gallant NM, Leydiker K, Tang H, Feuchtbaum L, Lorey F, Puckett R, Deignan JL, Neidich J, Dorrani N, Chang E, Barshop BA, Cederbaum SD, Abdenur JE, Wang RY. Mol Genet Metab. 2012 May;106(1):55-61. doi: 10.1016/j.ymgme.2012.02.007. Epub 2012 Feb 9. View abstract here

Clinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementation. Ong FS, Deignan JL, Kuo JZ, Bernstein KE, Rotter JI, Grody WW, Das K. Pharmacogenomics. 2012 Mar;13(4):465-75. doi: 10.2217/pgs.12.2. Review. View abstract here

PubMed: Joshua Deignan


Dorshkind, Kenneth, PhD

Murine B-1 B Cell Progenitors Initiate B-Acute Lymphoblastic Leukemia with Features of High-Risk Disease. Montecino-Rodriguez E, Li K, Fice M, Dorshkind K. J Immunol. 2014 Apr 21.

Shared signaling systems in myeloid cell-mediated muscle regeneration. Tidball JG, Dorshkind K, Wehling-Henricks M. Development. 2014 Mar;141(6):1184-96. doi: 10.1242/dev.098285.

Causes, consequences, and reversal of immune system aging. Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K. J Clin Invest. 2013 Mar 1;123(3):958-65. doi: 10.1172/JCI64096. Epub 2013 Mar 1. View abstract here

Genetic regulation of thymocyte progenitor aging. Berent-Maoz B, Montecino-Rodriguez E, Dorshkind K. Semin Immunol. 2012 Oct;24(5):303-8. doi: 10.1016/j.smim.2012.04.006. Epub 2012 May 2. View abstract here

Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Berent-Maoz B, Montecino-Rodriguez E, Signer RA, Dorshkind K. Blood. 2012 Jun 14;119(24):5715-21. doi: 10.1182/blood-2011-12-400002. Epub 2012 May 3. View abstract here

B-1 B cell development in the fetus and adult. Montecino-Rodriguez E, Dorshkind K. Immunity. 2012 Jan 27;36(1):13-21. doi: 10.1016/j.immuni.2011.11.017. View abstract here

PubMed: Kenneth Dorshkind


Drake, Thomas, MD

Response to Pomozi et al's research commentary. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. Circ Res. 2013 May 24;112(11):e152-3. doi: 10.1161/CIRCRESAHA.113.301666. Epub 2013 Apr 26. No abstract available.

Limited RNA editing in exons of mouse liver and adipose. Lagarrigue S, Hormozdiari F, Martin LJ, Lecerf F, Hasin Y, Rau C, Hagopian R, Xiao Y, Yan J, Drake TA, Ghazalpour A, Eskin E, Lusis AJ. Genetics. 2013 Apr;193(4):1107-15. doi: 10.1534/genetics.112.149054. Epub 2013 Feb 14.

Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ, Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, Kirby M, Drake TA, Drevon CA, Knight R, Gargalovic P, Kirchgessner T, Eskin E, Lusis AJ. Cell Metab. 2013 Jan 8;17(1):141-52. doi: 10.1016/j.cmet.2012.12.007.

The systems genetics resource: a web application to mine global data for complex disease traits. van Nas A, Pan C, Ingram-Drake LA, Ghazalpour A, Drake TA, Sobel EM, Papp JC, Lusis AJ. Front Genet. 2013 May 20;4:84. doi: 10.3389/fgene.2013.00084. eCollection 2013.

Applying perceptual and adaptive learning techniques for teaching introductory histopathology. Krasne S, Hillman JD, Kellman PJ, Drake TA. J Pathol Inform. 2013 Dec 31;4:34. doi: 10.4103/2153-3539.123991. eCollection 2013.

PubMed: Thomas Drake


Dry, Sarah, MD

RANKL Inhibitors Induce Osteonecrosis of the Jaw in Mice With Periapical Disease. Aghaloo TL, Cheong S, Bezouglaia O, Kostenuik P, Atti E, Dry SM, Pirih FQ, Tetradis S. J Bone Miner Res. 2014 Apr;29(4):843-54. doi: 10.1002/jbmr.2097.

Stage 0 osteonecrosis of the jaw in a patient on denosumab. Aghaloo TL, Dry SM, Mallya S, Tetradis S. J Oral Maxillofac Surg. 2014 Apr;72(4):702-16. doi: 10.1016/j.joms.2013.09.008. Epub 2014 Jan 4.

Clavicular and meningeal alveolar soft part sarcoma: An unusual case and literature review. James AW, Chang L, Levine B, Dry SM. J Orthop. 2014 Jan 10;11(1):48-53. doi: 10.1016/j.jor.2013.12.014. eCollection 2014 Mar.

From pericytes to perivascular tumours: correlation between pathology, stem cell biology, and tissue engineering. Mravic M, Asatrian G, Soo C, Lugassy C, Barnhill RL, Dry SM, Peault B, James AW. Int Orthop. 2014 Feb 25.

Giant cell tumor of bone in childhood: clinical aspects and novel therapeutic targets. Federman N, Brien EW, Narasimhan V, Dry SM, Sodhi M, Chawla SP. Paediatr Drugs. 2014 Feb;16(1):21-8. doi: 10.1007/s40272-013-0051-3.

A 92-gene cancer classifier predicts the site of origin for neuroendocrine tumors. Kerr SE, Schnabel CA, Sullivan PS, Zhang Y, Huang VJ, Erlander MG, Brachtel EF, Dry SM. Mod Pathol. 2013 Jul 12. doi: 10.1038/modpathol.2013.105. View abstract here

Periapical disease and bisphosphonates induce osteonecrosis of the jaws in mice. Kang B, Cheong S, Chaichanasakul T, Bezouglaia O, Atti E, Dry SM, Pirih FQ, Aghaloo TL, Tetradis S. J Bone Miner Res. 2013 Feb 20. doi: 10.1002/jbmr.1894. [Epub ahead of print] View abstract here

Malignant Melanoma With Neural Differentiation: An Exceptional Case Report and Brief Review of the Pertinent Literature. Su A, Dry SM, Binder SW, Said J, Shintaku P, Sarantopoulos GP. Am J Dermatopathol. 2013 Jun 18. View abstract here

Epigenetic activation of AP1 promotes squamous cell carcinoma metastasis. Ding X, Pan H, Li J, Zhong Q, Chen X, Dry SM, Wang CY. Sci Signal. 2013 Apr 30;6(273):ra28.1-13, S0-15. doi: 10.1126/scisignal.2003884. View abstract here

Novel Dedifferentiated Liposarcoma Xenograft Models Reveal PTEN Down-Regulation as a Malignant Signature and Response to PI3K Pathway Inhibition. Smith KB, Tran LM, Tam BM, Shurell EM, Li Y, Braas D, Tap WD, Christofk HR, Dry SM, Eilber FC, Wu H. Am J Pathol. 2013 Feb 12. doi:pii: S0002-9440(13)00040-0. 10.1016/j.ajpath.2013.01.002. View abstract here

Aurora rings: a novel endoscopic finding to distinguish inverted colonic diverticula from colon polyps. Share MD, Avila A, Dry SM, Share EJ. Gastrointest Endosc. 2013 Feb;77(2):308-12. doi: 10.1016/j.gie.2012.09.004. Epub 2012 Dec 1. No abstract available. View abstract here

SOX10 Expression Distinguishes Desmoplastic Melanoma From Its Histologic Mimics. Palla B, Su A, Binder S, Dry S. Am J Dermatopathol. 2013 Jan 3. View abstract here

Cell intrinsic role of COX-2 in pancreatic cancer development. Hill R, Li Y, Tran LM, Dry S, Calvopina JH, Garcia A, Kim C, Wang Y, Donahue TR, Herschman HR, Wu H. Mol Cancer Ther. 2012 Oct;11(10):2127-37. doi: 10.1158/1535-7163.MCT-12-0342. Epub 2012 Jul 10. View abstract here

Multisite validation study to determine performance characteristics of a 92-gene molecular cancer classifier. Kerr SE, Schnabel CA, Sullivan PS, Zhang Y, Singh V, Carey B, Erlander MG, Highsmith WE, Dry SM, Brachtel EF. Clin Cancer Res. 2012 Jul 15;18(14):3952-60. doi: 10.1158/1078-0432.CCR-12-0920. Epub 2012 May 30. View abstract here

3'-deoxy-3'-[18F]fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma: a pilot study to correlate imaging findings with tissue thymidine kinase 1 and Ki-67 activity and histopathologic response. Benz MR, Czernin J, Allen-Auerbach MS, Dry SM, Sutthiruangwong P, Spick C, Radu C, Weber WA, Tap WD, Eilber FC. Cancer. 2012 Jun 15;118(12):3135-44. doi: 10.1002/cncr.26630. Epub 2011 Oct 21. View abstract here

Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM, Butler PC. Diabetes. 2012 May;61(5):1250-62. doi: 10.2337/db11-1109. Epub 2012 Jan 20. Erratum in: Diabetes. 2012 Aug;61(8):2195. View abstract here

18F-FDG-PET/CT Imaging as an early survival predictor in patients with primary high-grade soft tissue sarcomas undergoing neoadjuvant therapy. Herrmann K, Benz MR, Czernin J, Allen-Auerbach MS, Tap WD, Dry SM, Schuster T, Eckardt JJ, Phelps ME, Weber WA, Eilber FC. Clin Cancer Res. 2012 Apr 1;18(7):2024-31. doi: 10.1158/1078-0432.CCR-11-2139. Epub 2012 Feb 14. View abstract here

Genital rhabdomyoma of the urethra in an infant girl. Lu DY, Chang S, Cook H, Alizadeh Y, Karam AK, Moatamed NA, Dry SM. Hum Pathol. 2012 Apr;43(4):597-600. doi: 10.1016/j.humpath.2011.06.012. Epub 2011 Oct 10. View abstract here

Stuck between a scalpel and a rock, or molecular pathology and legal-ethical issues in use of tissues for clinical care and research: what must a pathologist know? Dry S, Grody WW, Papagni P. Am J Clin Pathol. 2012 Mar;137(3):346-55. doi: 10.1309/AJCPS26UKHNYCEAV. View abstract here

Diagnosis of dysplasia in upper gastro-intestinal tract biopsies through digital microscopy. Gui D, Cortina G, Naini B, Hart S, Gerney G, Dawson D, Dry S. J Pathol Inform. 2012;3:27. Epub 2012 Aug 25. View abstract here

PubMed: Sarah Dry


Dubinett, Steven, MD

Distinguishing Patients with Stage I Lung Cancer Versus Control Individuals using Serum Mass Profiling. Hanas JS, Peyton MD, Lerner MR, Lightfoot SA, Deb SJ, Hanas RJ, Vu NT, Kupiec TC, Stowell DE, Brackett DJ, Dubinett SM, Hocker JR. Cancer Invest. 2014 Apr;32(4):136-43. doi: 10.3109/07357907.2014.883528. Epub 2014 Feb 28.

Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. Ooi AT, Gower AC, Zhang KX, Vick JL, Hong LS, Nagao B, Wallace WD, Elashoff D, Walser TC, Dubinett SM, Pellegrini M, Lenburg ME, Spira AE, Gomperts BN. Cancer Prev Res (Phila). 2014 Mar 11. [Epub ahead of print]

Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer. Garon EB, Christofk HR, Hosmer W, Britten CD, Bahng A, Crabtree MJ, Hong CS, Kamranpour N, Pitts S, Kabbinavar F, Patel C, von Euw E, Black A, Michelakis ED, Dubinett SM, Slamon DJ. J Cancer Res Clin Oncol. 2014 Mar;140(3):443-52. doi: 10.1007/s00432-014-1583-9. Epub 2014 Jan 18.

PGE2-driven Expression of c-Myc and OncomiR-17-92 Contributes to Apoptosis Resistance in NSCLC. Krysan K, Kusko R, Grogan T, O'Hearn J, Reckamp KL, Walser TC, Garon EB, Lenburg ME, Sharma S, Spira AE, Elashoff D, Dubinett SM. Mol Cancer Res. 2014 Jan 27. [Epub ahead of print]

A novel molecular pathway for snail-dependent, SPARC-mediated invasion in non-small cell lung cancer pathogenesis. Grant JL, Fishbein MC, Hong LS, Krysan K, Minna JD, Shay JW, Walser TC, Dubinett SM. Cancer Prev Res (Phila). 2014 Jan;7(1):150-60. doi: 10.1158/1940-6207.CAPR-13-0263. Epub 2013 Nov 19.

Models of interinstitutional partnerships between research intensive universities and minority serving institutions (MSI) across the Clinical Translational Science Award (CTSA) consortium. Ofili EO, Fair A, Norris K, Verbalis JG, Poland R, Bernard G, Stephens DS, Dubinett SM, Imperato-McGinley J, Dottin RP, Pulley J, West A, Brown A, Mellman TA. Clin Transl Sci. 2013 Dec;6(6):435-43. doi: 10.1111/cts.12118. Epub 2013 Oct 3.

IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer. Kachroo P, Lee MH, Zhang L, Baratelli F, Lee G, Srivastava MK, Wang G, Walser TC, Krysan K, Sharma S, Dubinett SM, Lee JM. J Exp Clin Cancer Res. 2013 Nov 25;32(1):97. doi: 10.1186/1756-9966-32-97.

Challenge and Opportunity of Targeted Lung Cancer Chemoprevention. Dubinett SM, Spira A. J Clin Oncol. 2013 Sep 3. View abstract here

Elevated neutrophil gelatinase-associated lipocalin contributes to erlotinib resistance in non-small cell lung cancer. Krysan K, Cui X, Gardner BK, Reckamp KL, Wang X, Hong L, Walser TC, Rodriguez NL, Pagano PC, Garon EB, Brothers JF 2nd, Elashoff D, Lee JM, Spira AE, Sharma S, Fishbein MC, Dubinett SM. Am J Transl Res. 2013 Aug 15;5(5):481-96. View abstract here

Effect of epigenetic histone modifications on E-cadherin splicing and expression in lung cancer. Liao W, Jordaan G, Srivastava MK, Dubinett S, Sharma S, Sharma S. Am J Cancer Res. 2013 Aug 14;3(4):374-89. View abstract here

The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth. Garon EB, Finn RS, Hamidi H, Dering J, Pitts S, Kamranpour N, Desai AJ, Hosmer W, Ide S, Avsar E, Jensen MR, Quadt C, Liu M, Dubinett SM, Slamon DJ. Mol Cancer Ther. 2013 Jun;12(6):890-900. doi: 10.1158/1535-7163.MCT-12-0998. Epub 2013 Mar 14. View abstract here

Characteristics of Lung Cancers Harboring NRAS Mutations. Ohashi K, Sequis LV, Arcila ME, Lovly CM, Chen X, Rudin CM, Moran T, Camidge DR, Vnencak-Jones CL, Berry L, Pan Y, Sasaki H, Engelman JA, Garon EB, Dubinett SM, Franklin WA, Riely GJ, Sos ML, Kris MG, Dias-Santagata D, Ladanyi M, Bunn PA Jr, Pao W. Clin Cancer Res. 2013 Mar 20. View abstract here

TLR3 agonists and proinflammatory antitumor activities. Sharma S, Zhu L, Davoodi M, Harris-White M, Lee JM, St John M, Salgia R, Dubinett S. Expert Opin Ther Targets. 2013 Mar 19. View abstract here

The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth. Garon EB, Finn RS, Hamidi H, Dering J, Pitts S, Kamranpour N, Desai AJ, Hosmer W, Ide S, Avsar E, Rugaard Jensen M, Quadt C, Liu M, Dubinett SM, Slamon DJ. Mol Cancer Ther. 2013 Mar 14. View abstract here

Antiestrogen fulvestrant enhances the antiproliferative effects of epidermal growth factor receptor inhibitors in human non-small-cell lung cancer. Garon EB, Pietras RJ, Finn RS, Kamranpour N, Pitts S, Márquez-Garbán DC, Desai AJ, Dering J, Hosmer W, von Euw EM, Dubinett SM, Slamon DJ. J Thorac Oncol. 2013 Mar;8(3):270-8. doi: 10.1097/JTO.0b013e31827d525c. View abstract here

Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer. Gomperts BN, Walser TC, Spira A, Dubinett SM. Cancer Prev Res (Phila). 2013 Jan;6(1):4-7. doi: 10.1158/1940-6207.CAPR-12-0470. Epub 2012 Dec 11. View abstract here

Green tea inhibits cycolooxygenase-2 in non-small cell lung cancer cells through the induction of Annexin-1. Lu QY, Jin Y, Mao JT, Zhang ZF, Heber D, Dubinett SM, Rao J. Biochem Biophys Res Commun. 2012 Nov 2;427(4):725-30. doi: 10.1016/j.bbrc.2012.09.125. Epub 2012 Oct 2. View abstract here

Snail controls the mesenchymal phenotype and drives erlotinib resistance in oral epithelial and head and neck squamous cell carcinoma cells. Dennis M, Wang G, Luo J, Lin Y, Dohadwala M, Abemayor E, Elashoff DA, Sharma S, Dubinett SM, St John MA. Otolaryngol Head Neck Surg. 2012 Oct;147(4):726-32. Epub 2012 May 7. View abstract here

Apricoxib upregulates 15-PGDH and PGT in tobacco-related epithelial malignancies. St John MA, Wang G, Luo J, Dohadwala M, Hu D, Lin Y, Dennis M, Lee JM, Elashoff D, Lawhon T, Zaknoen SL, Burrows FJ, Dubinett SM. Br J Cancer. 2012 Aug 7;107(4):707-12. doi: 10.1038/bjc.2012.203. Epub 2012 Jul 24. View abstract here

Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer. Huynh TP, Mah V, Sampson VB, Chia D, Fishbein MC, Horvath S, Alavi M, Wu DC, Harper J, Sarafian T, Dubinett SM, Langhans SA, Goodglick L, Rajasekaran AK. Am J Physiol Lung Cell Mol Physiol. 2012 Jun 1;302(11):L1150-8. doi: 10.1152/ajplung.00384.2010. Epub 2012 Feb 17. View abstract here

A novel modular polymer platform for the treatment of head and neck squamous cell carcinoma in an animal model. Hu D, Lau OD, Wang L, Wang G, Schaue D, Zhu L, Huang M, Lin Y, Dennis M, Abemayor E, Elashoff DA, Dubinett SM, McBride WH, Sharma S, Wu B, St John MA. View abstract here

PubMed: Steven Dubinett


Effros, Rita, PhD

Functional assessment of pharmacological telomerase activators in human T cells. Molgora B, Bateman R, Sweeney G, Finger D, Dimler T, Effros RB, Valenzuela HF. Cells. 2013 Jan 14;2(1):57-66. doi: 10.3390/cells2010057.

Preface: aging and oncogenesis. Effros RB. Crit Rev Oncog. 2013;18(6):485-7

Accelerated Aging in HIV/AIDS: Novel Biomarkers of Senescent Human CD8+ T Cells. Chou JP, Ramirez CM, Wu JE, Effros RB. PLoS One. 2013 May 22;8(5):e64702. doi: 10.1371/journal.pone.0064702. View abstract here

Immunosenescence is associated with presence of Kaposi's sarcoma in antiretroviral treated human immunodeficiency virus infection. Unemori PA, Leslie KS, Hunt PW, Sinclair E, Epling L, Mitsuyasu R, Effros RB, Dock J, Dollard SG, Deeks SG, Martin JN, Maurer TS. AIDS. 2013 Feb 21. [Epub ahead of print] View abstract here

T cell replicative senescence in human aging. Chou JP, Effros RB. Curr Pharm Des. 2013;19(9):1680-98. View abstract here

HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group. High KP, Brennan-Ing M, Clifford DB, Cohen MH, Currier J, Deeks SG, Deren S, Effros RB, Gebo K, Goronzy JJ, Justice AC, Landay A, Levin J, Miotti PG, Munk RJ, Nass H, Rinaldo CR Jr, Shlipak MG, Tracy R, Valcour V, Vance DE, Walston JD, Volberding P; OAR Working Group on HIV and Aging. J Acquir Immune Defic Syndr. 2012 Jul 1;60 Suppl 1:S1-18. doi: 10.1097/QAI.0b013e31825a3668. View abstract here

Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein. Watson MB, Richter F, Lee SK, Gabby L, Wu J, Masliah E, Effros RB, Chesselet MF. Exp Neurol. 2012 Oct;237(2):318-34. doi: 10.1016/j.expneurol.2012.06.025. Epub 2012 Jun 27. View abstract here

PubMed: Rita Effros


Fishbein, Michael, MD


Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy. Chen PS, Chen LS, Fishbein MC, Lin SF, Nattel S. Circ Res. 2014 Apr 25;114(9):1500-15. doi: 10.1161/CIRCRESAHA.114.303772.

Transcatheter aortic valve implantation: status and challenges. Fishbein GA, Schoen FJ, Fishbein MC. Cardiovasc Pathol. 2014 Mar-Apr;23(2):65-70. doi: 10.1016/j.carpath.2013.10.001. Epub 2013 Oct 8.

Autonomic nerve activity and blood pressure in ambulatory dogs. Hellyer J, George Akingba A, Rhee KS, Tan AY, Lane KA, Shen C, Patel J, Fishbein MC, Chen PS. Heart Rhythm. 2014 Feb;11(2):307-13. doi: 10.1016/j.hrthm.2013.11.022. Epub 2013 Nov 22.

FGF23 protein expression in coronary arteries is associated with impaired kidney function. van Venrooij NA, Pereira RC, Tintut Y, Fishbein MC, Tumber N, Demer LL, Salusky IB, Wesseling-Perry K. Nephrol Dial Transplant. 2014 Jan 23.

A novel molecular pathway for snail-dependent, SPARC-mediated invasion in non-small cell lung cancer pathogenesis. Grant JL, Fishbein MC, Hong LS, Krysan K, Minna JD, Shay JW, Walser TC, Dubinett SM. Cancer Prev Res (Phila). 2014 Jan;7(1):150-60. doi: 10.1158/1940-6207.CAPR-13-0263. Epub 2013 Nov 19.

Bifid cardiac apex in a 25-year-old male with sudden cardiac death. Wu A, Kay D, Fishbein MC. Cardiovasc Pathol. 2014 Jan-Feb;23(1):59-60. doi: 10.1016/j.carpath.2013.06.003. Epub 2013 Aug 6.

The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation. Berry GJ, Burke MM, Andersen C, Bruneval P, Fedrigo M, Fishbein MC, Goddard M, Hammond EH, Leone O, Marboe C, Miller D, Neil D, Rassl D, Revelo MP, Rice A, Rene Rodriguez E, Stewart S, Tan CD, Winters GL, West L, Mehra MR, Angelini A. J Heart Lung Transplant. 2013 Dec;32(12):1147-62. doi: 10.1016/j.healun.2013.08.011.

Pulmonary hypertension complicating connective tissue disease. Lynch JP 3rd, Belperio JA, Saggar R, Fishbein MC, Saggar R. Semin Respir Crit Care Med. 2013 Oct;34(5):581-99. doi: 10.1055/s-0033-1356547. Epub 2013 Sep 13. View abstract here

CXCR3 Ligands Are Associated with the Continuum of Diffuse Alveolar Damage to Chronic Lung Allograft Dysfunction. Shino MY, Weigt SS, Li N, Palchevskiy V, Derhovanessian A, Saggar R, Sayah DM, Gregson AL, Fishbein MC, Ardehali A, Ross DJ, Lynch JP 3rd, Elashoff RM, Belperio JA. Am J Respir Crit Care Med. 2013 Sep 24. View abstract here

The CD44(high) Tumorigenic Subsets in Lung Cancer Biospecimens Are Enriched for Low miR-34a Expression. Basak SK, Veena MS, Oh S, Lai C, Vangala S, Elashoff D, Fishbein MC, Sharma S, Rao NP, Rao D, Phan R, Srivatsan ES, Batra RK. PLoS One. 2013 Sep 3;8(9):e73195. doi: 10.1371/journal.pone.0073195. View abstract here

Primary endocardial fibroelastosis: an underappreciated cause of cardiomyopathy in children. Seki A, Patel S, Ashraf S, Perens G, Fishbein MC. Cardiovasc Pathol. 2013 Mar 18. doi:pii: S1054-8807(13)00101-4. 10.1016/j.carpath.2013.02.003. View abstract here

Low-level vagus nerve stimulation upregulates small conductance calcium-activated potassium channels in the stellate ganglion. Shen MJ, Hao-Che Chang X, Park HW, George Akingba A, Chang PC, Zheng Zhang X, Lin SF, Shen C, Chen LS, Chen Z, Fishbein MC, Chiamvimonvat N, Chen PS. Heart Rhythm. 2013 Jan 26. doi:pii: S1547-5271(13)00055-6. 10.1016/j.hrthm.2013.01.029. View abstract here

LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS, Shaw RJ. Cancer Cell. 2013 Feb 11;23(2):143-58. doi: 10.1016/j.ccr.2012.12.008. Epub 2013 Jan 24. View abstract here

Interaction between Pseudomonas and CXC Chemokines Increases Risk of Bronchiolitis Obliterans Syndrome and Death in Lung Transplantation. Gregson AL, Wang X, Weigt SS, Palchevskiy V, Lynch JP 3rd, Ross DJ, Kubak BM, Saggar R, Fishbein MC, Ardehali A, Li G, Elashoff R, Belperio JA. Am J Respir Crit Care Med. 2013 Mar 1;187(5):518-26. doi: 10.1164/rccm.201207-1228OC. Epub 2013 Jan 17. View abstract here

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin. Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS, Shaw RJ. Cancer Cell. 2013 Feb 11;23(2):143-58. doi: 10.1016/j.ccr.2012.12.008. Epub 2013 Jan 24. View abstract here

Low-Level Vagus Nerve Stimulation Upregulates Small Conductance Calcium Activated Potassium Channels in the Stellate Ganglion. Shen MJ, Chang HC, Park HW, George Akingba A, Chang PC, Zhang Z, Lin SF, Shen C, Chen LS, Chen Z, Fishbein MC, Chiamvimonvat N, Chen PS. Heart Rhythm. 2013 Jan 25. doi:pii: S1547-5271(13)00055-6. 10.1016/j.hrthm.2013.01.029. View abstract here

Canonical Wnt/β-catenin signaling in epicardial fibrosis of failed pediatric heart allografts with diastolic dysfunction. Ye B, Ge Y, Perens G, Hong L, Xu H, Fishbein MC, Li F. Cardiovasc Pathol. 2013 Jan-Feb;22(1):54-7. doi: 10.1016/j.carpath.2012.03.004. Epub 2012 Apr 2. View abstract here

Pathology of pulmonary antibody-mediated rejection: 2012 update from the Pathology Council of the ISHLT. Berry G, Burke M, Andersen C, Angelini A, Bruneval P, Calbrese F, Fishbein MC, Goddard M, Leone O, Maleszewski J, Marboe C, Miller D, Neil D, Padera R, Rassi D, Revello M, Rice A, Stewart S, Yousem SA. J Heart Lung Transplant. 2013 Jan;32(1):14-21. doi: 10.1016/j.healun.2012.11.005. View abstract here

Sympathetic nerve fibers and ganglia in canine cervical vagus nerves: Localization and quantitation. Onkka P, Maskoun W, Rhee KS, Patel J, Tan J, Chen LS, Vinters HV, Fishbein MC, Chen PS. Heart Rhythm. 2012 Dec 11. doi:pii: S1547-5271(12)01449-X. 10.1016/j.hrthm.2012.12.015. View abstract here

Morphologic and immunohistochemical findings in antibody-mediated rejection of the cardiac allograft. Fishbein GA, Fishbein MC. Hum Immunol. 2012 Dec;73(12):1213-7. doi: 10.1016/j.humimm.2012.07.011. Epub 2012 Jul 16. View abstract here

Extracardiac neural remodeling in humans with cardiomyopathy. Ajijola OA, Wisco JJ, Lambert HW, Mahajan A, Stark E, Fishbein MC, Shivkumar K. Circ Arrhythm Electrophysiol. 2012 Oct;5(5):1010-116. doi: 10.1161/CIRCEP.112.972836. Epub 2012 Aug 23. View abstract here

Obliterative (constrictive) bronchiolitis. Lynch JP 3rd, Weigt SS, DerHovanessian A, Fishbein MC, Gutierrez A, Belperio JA. Semin Respir Crit Care Med. 2012 Oct;33(5):509-32. Epub 2012 Sep 21. View abstract here

Pulmonary alveolar proteinosis. Wang T, Lazar CA, Fishbein MC, Lynch JP 3rd. Semin Respir Crit Care Med. 2012 Oct;33(5):498-508. Epub 2012 Sep 21. View abstract here

A fluorescence lifetime imaging classification method to investigate the collagen to lipid ratio in fibrous caps of atherosclerotic plaque. Phipps JE, Sun Y, Fishbein MC, Marcu L. Lasers Surg Med. 2012 Sep;44(7):564-71. doi: 10.1002/lsm.22059. Epub 2012 Aug 6. View abstract here

Marked acceleration of atherosclerosis after Lactobacillus casei-induced coronary arteritis in a mouse model of Kawasaki disease. Chen S, Lee Y, Crother TR, Fishbein M, Zhang W, Yilmaz A, Shimada K, Schulte DJ, Lehman TJ, Shah PK, Arditi M. Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):e60-71. doi: 10.1161/ATVBAHA.112.249417. Epub 2012 May 24. View abstract here

Type I immune response cytokine-chemokine cascade is associated with pulmonary arterial hypertension. Ross DJ, Strieter RM, Fishbein MC, Ardehali A, Belperio JA. J Heart Lung Transplant. 2012 Aug;31(8):865-73. doi: 10.1016/j.healun.2012.04.008. Epub 2012 May 30. View abstract here

PubMed: Michael Fishbein


French, Samuel, MD, PhD

Systematic Analysis of Enhancer and Critical cis-acting RNA Elements in the Protein Encoding Region of the Hepatitis C Virus Genome. Chu D, Ren S, Hu S, Wang WG, Subramanian A, Contreras D, Kanagavel V, Chung E, Ko J, Amirtham Jacob Appadorai RS, Sinha S, Jalali Z, Hardy DW, French SW, Arumugaswami V. J Virol. 2013 Mar 13. View abstract here

HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma. Nguyen Kovochich A, Arensman M, Lay AR, Rao NP, Donahue T, Li X, French SW, Dawson DW. Cancer. 2013 Feb 1;119(3):529-39. doi: 10.1002/cncr.27725. Epub 2012 Aug 22. View abstract here

SAMe treatment prevents the ethanol-induced epigenetic alterations of genes in the Toll-like receptor pathway. Khachatoorian R, Dawson D, Maloney EM, Wang J, French BA, French SW, French SW. Exp Mol Pathol. 2013 Feb;94(1):243-6. doi: 10.1016/j.yexmp.2012.09.024. Epub 2012 Oct 6. View abstract here

Metabolic effects of sleeve gastrectomy in female rat model of diet-induced obesity. Brinckerhoff TZ, Bondada S, Lewis CE, French SW, DeUgarte DA. Surg Obes Relat Dis. 2013 Jan-Feb;9(1):108-12. doi: 10.1016/j.soard.2011.09.025. Epub 2011 Oct 14. View abstract here

Divergent antiviral effects of bioflavonoids on the hepatitis C virus life cycle. Khachatoorian R, Arumugaswami V, Raychaudhuri S, Yeh GK, Maloney EM, Wang J, Dasgupta A, French SW. Virology. 2012 Nov 25;433(2):346-55. doi: 10.1016/j.virol.2012.08.029. Epub 2012 Sep 11. View abstract here

Quercetin: bioflavonoids as part of interferon-free hepatitis C therapy? Lu N, Khachatoorian R, French SW. Expert Rev Anti Infect Ther. 2012 Jun;10(6):619-21. doi: 10.1586/eri.12.52. View abstract here

A cell-permeable hairpin peptide inhibits hepatitis C viral nonstructural protein 5A-mediated translation and virus production. Khachatoorian R, Arumugaswami V, Ruchala P, Raychaudhuri S, Maloney EM, Miao E, Dasgupta A, French SW. Hepatology. 2012 Jun;55(6):1662-72. doi: 10.1002/hep.25533. Epub 2012 Jan 30. View abstract here

PubMed: Samuel French


Ganz, Tomas, MD, PhD

Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Rodriguez R, Jung CL, Gabayan V, Deng JC, Ganz T, Nemeth E, Bulut Y. Infect Immun. 2014 Feb;82(2):745-52. doi: 10.1128/IAI.00983-13. Epub 2013 Dec 2.

Mouse models of anemia of cancer. Kim A, Rivera S, Shprung D, Limbrick D, Gabayan V, Nemeth E, Ganz T. PLoS One. 2014 Mar 28;9(3):e93283. doi: 10.1371/journal.pone.0093283. eCollection 2014.

Testing the iron hypothesis in a mouse model of atherosclerosis. Kautz L, Gabayan V, Wang X, Wu J, Onwuzurike J, Jung G, Qiao B, Lusis AJ, Ganz T, Nemeth E. Cell Rep. 2013 Dec 12;5(5):1436-42. doi: 10.1016/j.celrep.2013.11.009. Epub 2013 Dec 5.

High-throughput screening of small molecules identifies hepcidin antagonists. Fung E, Sugianto P, Hsu J, Damoiseaux R, Ganz T, Nemeth E. Mol Pharmacol. 2013 Mar;83(3):681-90. doi: 10.1124/mol.112.083428. Epub 2013 Jan 4. View abstract here

Cellular catabolism of the iron-regulatory Peptide hormone hepcidin. Preza GC, Pinon R, Ganz T, Nemeth E. PLoS One. 2013;8(3):e58934. doi: 10.1371/journal.pone.0058934. Epub 2013 Mar 11. View abstract here

High-throughput screening of small molecules identifies hepcidin antagonists. Fung E, Sugianto P, Hsu J, Damoiseaux R, Ganz T, Nemeth E. Mol Pharmacol. 2013 Mar;83(3):681-90. doi: 10.1124/mol.112.083428. Epub 2013 Jan 4. View abstract here

Hepcidin is a key mediator of anemia of inflammation in Crohn's disease. Basseri RJ, Nemeth E, Vassilaki ME, Basseri B, Enayati P, Shaye O, Bourikas LA, Ganz T, Papadakis KA. J Crohns Colitis. 2012 Dec 5. doi:pii: S1873-9946(12)00450-3. 10.1016/j.crohns.2012.10.013 View abstract here

Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Ramos E, Ruchala P, Goodnough JB, Kautz L, Preza GC, Nemeth E, Ganz T. Blood. 2012 Nov 1;120(18):3829-36. doi: 10.1182/blood-2012-07-440743. Epub 2012 Sep 18. View abstract here

Hepcidin and iron homeostasis. Ganz T, Nemeth E. Biochim Biophys Acta. 2012 Sep;1823(9):1434-43. doi: 10.1016/j.bbamcr.2012.01.014. Epub 2012 Jan 26. Review. View abstract here

IOD in rhinos--immunity group report: report from the Immunity, Genetics and Toxicology Working Group of the International Workshop on Iron Overload Disorder in Browsing Rhinoceros (February 2011). Ganz T, Goff J, Klasing K, Nemeth E, Roth T. J Zoo Wildl Med. 2012 Sep;43(3 Suppl):S117-9. View abstract here

Iron homeostasis and its disorders in mice and men: potential lessons for rhinos. Ganz T, Nemeth E. J Zoo Wildl Med. 2012 Sep;43(3 Suppl):S19-26. Review. View abstract here

Inhibition of hepcidin transcription by growth factors. Goodnough JB, Ramos E, Nemeth E, Ganz T. Hepatology. 2012 Jul;56(1):291-9. doi: 10.1002/hep.25615. Epub 2012 Jun 18. View abstract here

Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E. Cell Metab. 2012 Jun 6;15(6):918-24. doi: 10.1016/j.cmet.2012.03.018. View abstract here

Iron metabolism: interactions with normal and disordered erythropoiesis. Ganz T, Nemeth E. Cold Spring Harb Perspect Med. 2012 May;2(5):a011668. doi: 10.1101/cshperspect.a011668. View abstract here

Macrophages and systemic iron homeostasis. Ganz T. J Innate Immun. 2012;4(5-6):446-53. doi: 10.1159/000336423. Epub 2012 Mar 21. Review. View abstract here

PubMed: Tomas Ganz


Garner, Omai, PhD

Multi-center evaluation of the VITEK® MS system for mass spectrometric identification of non-Enterobacteriaceae Gram-negative bacilli. Manji R, Bythrow M, Branda JA, Burnham CA, Ferraro MJ, Garner OB, Jennemann R, Lewinski MA, Mochon AB, Procop GW, Richter SS, Rychert JA, Sercia L, Westblade LF, Ginocchio CC. Eur J Clin Microbiol Infect Dis. 2013 Sep 10. View abstract here

Multi-centre evaluation of mass spectrometric identification of anaerobic bacteria using the VITEK® MS system. Garner O, Mochon A, Branda J, Burnham CA, Bythrow M, Ferraro M, Ginocchio C, Jennemann R, Manji R, Procop GW, Richter S, Rychert J, Sercia L, Westblade L, Lewinski M. Clin Microbiol Infect. 2013 Jul 4. doi: 10.1111/1469-0691.12317. View abstract here

Identification of Enterobacteriaceae by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using the VITEK MS system. Richter SS, Sercia L, Branda JA, Burnham CA, Bythrow M, Ferraro MJ, Garner OB, Ginocchio CC, Jennemann R, Lewinski MA, Manji R, Mochon AB, Rychert JA, Westblade LF, Procop GW. Eur J Clin Microbiol Infect Dis. 2013 Jul 2. View abstract here

Multicenter Study Evaluating the Vitek MS System for Identification of Medically Important Yeasts. Westblade LF, Jennemann R, Branda JA, Bythrow M, Ferraro MJ, Garner OB, Ginocchio CC, Lewinski MA, Manji R, Mochon AB, Procop GW, Richter SS, Rychert JA, Sercia L, Burnham CA. J Clin Microbiol. 2013 Jul;51(7):2267-72. doi: 10.1128/JCM.00680-13. Epub 2013 May 8. View abstract here

Multicenter Evaluation of the Vitek MS Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry System for Identification of Gram-Positive Aerobic Bacteria. Rychert J, Burnham CA, Bythrow M, Garner OB, Ginocchio CC, Jennemann R, Lewinski MA, Manji R, Mochon AB, Procop GW, Richter SS, Sercia L, Westblade LF, Ferraro MJ, Branda JA. J Clin Microbiol. 2013 Jul;51(7):2225-31. doi: 10.1128/JCM.00682-13. Epub 2013 May 8. View abstract here

N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland. Bush KT, Crawford BE, Garner OB, Nigam KB, Esko JD, Nigam SK. J Biol Chem. 2012 Dec 7;287(50):42064-70. doi: 10.1074/jbc.M112.423327. Epub 2012 Oct 11. View abstract here

PubMed: Omai Garner


Gatti, Richard, MD

Aberrant overexpression of miR-421 downregulates ATM and leads to a pronouced DSB repair defect and clinical radiosensitivity in SKK squamous cell carcinoma. Mansour WY, Bogdanova NV, Kasten-Pisula U, Rieckmann T, Kocher S, Borgmann K, Baumann M, Krause M, Petersen C, Hu H, Gatti RA, Dikomey E, Dork T, Dahm-Daphi J. Radiotherapy Oncol 106: 147-154, 2013.

Repair of UV photolesions in xeroderma pigmentosum Group C cells is induced by translational readthrough of premature termination codons. Kuschal C, DiGiovanna JJ, Khan SG, Gatti RA, Kraemer KH. Proc National Academy Science (USA). Online November 2013.

Extreme growth failure is a common presentation of ligase IV deficiency. Murray JE, Bicknell LS, Yigit G, Duker AL, van Kogelenberg M, Haghahegh S, Wieczorek D, Kayserili H, Albert MH, Wise CA, Brandon J, Kleefstra T, Warris A, van der Flier M, Bamforth JS, Doonanco K, Anes L, Ma A, Field M, Johnson D, Shackley F, Firth H, Woods CG, Nurnberg P, Gatti RA, Hurles M, Bober MB, Wollnik B, Jackson AP. Hum Mutation 2013

A-T Winnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-trheatening radiotoxicity. Nakamura K, Fike F, Haghahegh S, Saunders-Pullman R, Dawson A, Doerk T, Gatti RA. Mol Genet & Genomic Med. In press.

Mutation of Senataxin Alters Disease-Specific Transcriptional Networks in Patients with Ataxia with Oculomotor Apraxia Type 2. Fogel BL, Cho E, Wahnich A, Gao F, Becherel OJ, Wang X, Fike F, Chen L, Criscuolo C, De Michele G, Filla A, Collins A, Hahn AF, Gatti RA, Konopka G, Perlman S, Lavin MF, Geschwind DH, Coppola G. Hum Mol Genet. 2014 Apr 23.

Homozygous mutation of MTPAP causes cellular radiosensitivity and persistent DNA double-strand breaks. Martin NT, Nakamura K, Paila U, Woo J, Brown C, Wright JA, Teraoka SN, Haghayegh S, McCurdy D, Schneider M, Hu H, Quinlan AR, Gatti RA, Concannon P. Cell Death Dis. 2014 Mar 20;5:e1130. doi: 10.1038/cddis.2014.99.

Deep-intronic ATM mutation detected by genomic resequencing and corrected in vitro by antisense morpholino oligonucleotide (AMO). Cavalieri S, Pozzi E, Gatti RA, Brusco A. Eur J Hum Genet. 2013 Jul;21(7):774-8. doi: 10.1038/ejhg.2012.266. Epub 2012 Dec 5. View abstract here

A new series of novel small molecular weight compounds induce readthrough of all three types of nonsense mutations in the ATM gene. Du L, Jung ME, Damoiseaux R, Completo G, Fike F, Ku JM, Nahas S, Piao C, Hu H, Gatti RA. Mol Ther. 2013 Jun 18. doi: 10.1038/mt.2013.150. View abstract here

Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions. Ambrose M, Gatti RA. Blood. 2013 May 16;121(20):4036-45. doi: 10.1182/blood-2012-09-456897. Epub 2013 Feb 25. View abstract here

ATM-Dependent MiR-335 Targets CtIP and Modulates the DNA Damage Response. Martin NT, Nakamura K, Davies R, Nahas SA, Brown C, Tunuguntla R, Gatti RA, Hu H. PLoS Genet. 2013 May;9(5):e1003505. doi: 10.1371/journal.pgen.1003505. Epub 2013 May 16. View abstract here

SMRT compounds correct nonsense mutations in primary immunodeficiency and other genetic models. Gatti RA. Ann N Y Acad Sci. 2012 Feb;1250:33-40. doi: 10.1111/j.1749-6632.2012.06467.x. View abstract here

Defective DNA double-strand break repair in pediatric systemic lupus erythematosus. Davies RC, Pettijohn K, Fike F, Wang J, Nahas SA, Tunuguntla R, Hu H, Gatti RA, McCurdy D. Arthritis Rheum. 2012 Feb;64(2):568-78. doi: 10.1002/art.33334. View abstract here

Common copy number variations in fifty radiosensitive cell lines. Li X, Zhou J, Nahas SA, Wan H, Hu H, Gatti RA. Genomics. 2012 Feb;99(2):96-100. doi: 10.1016/j.ygeno.2011.11.001. Epub 2011 Nov 9. View abstract here

Heterotopic Purkinje cells in ataxia-telangiectasia. Bottini AR, Gatti RA, Wirenfeldt M, Vinters HV. Neuropathology. 2012 Feb;32(1):23-9. doi: 10.1111/j.1440-1789.2011.01210.x. Epub 2011 Mar 29. View abstract here

Comprehensive profiling of radiosensitive human cell lines with DNA damage response assays identifies the neutral comet assay as a potential surrogate for clonogenic survival. Nahas SA, Davies R, Fike F, Nakamura K, Du L, Kayali R, Martin NT, Concannon P, Gatti RA. Radiat Res. 2012 Feb;177(2):176-86. Epub 2011 Sep 30. View abstract here

Ataxia-telangiectasia. Perlman SL, Boder Deceased E, Sedgewick RP, Gatti RA. Handb Clin Neurol. 2012;103:307-32. doi: 10.1016/B978-0-444-51892-7.00019-X. View abstract here

PubMed: Richard Gatti


Gjertson, David, PhD

Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma. Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z, Auerbach M, Ng C, Avramis E, Seja E, Villanueva A, McCannel TA, Ishiyama A, Czernin J, Radu CG, Wang X, Gjertson DW, Cochran AJ, Cornetta K, Wong DJ, Kaplan-Lefko P, Hamid O, Samlowski W, Cohen PA, Daniels GA, Mukherji B, Yang L, Zack JA, Kohn DB, Heath JR, Glaspy JA, Witte ON, Baltimore D, Economou JS, Ribas A. Clin Cancer Res. 2014 Apr 9.

Comprehensive assessment and standardization of solid phase multiplex-bead arrays for the detection of antibodies to HLA. Reed EF, Rao P, Zhang Z, Gebel H, Bray RA, Guleria I, Lunz J, Mohanakumar T, Nickerson P, Tambur AR, Zeevi A, Heeger PS, Gjertson D. Am J Transplant. 2013 Jul;13(7):1859-70. doi: 10.1111/ajt.12287. Epub 2013 Jun 13. View abstract here

Kidney paired donation in the presence of donor-specific antibodies. Blumberg JM, Gritsch HA, Reed EF, Cecka JM, Lipshutz GS, Danovitch GM, McGuire S, Gjertson DW, Veale JL. Kidney Int. 2013 May 29. doi: 10.1038/ki.2013.206. View abstract here

Allelic Exclusion and Peripheral Reconstitution by TCR Transgenic T Cells Arising From Transduced Human Hematopoietic Stem/Progenitor Cells. Giannoni F, Hardee CL, Wherley J, Gschweng E, Senadheera S, Kaufman ML, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte ON, Economou JS, Ribas A, Kohn DB. Mol Ther. 2013 Feb 5. doi: 10.1038/mt.2013.8. View abstract here

Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. Candotti F, Shaw KL, Muul L, Carbonaro D, Sokolic R, Choi C, Schurman SH, Garabedian E, Kesserwan C, Jagadeesh GJ, Fu PY, Gschweng E, Cooper A, Tisdale JF, Weinberg KI, Crooks GM, Kapoor N, Shah A, Abdel-Azim H, Yu XJ, Smogorzewska M, Wayne AS, Rosenblatt HM, Davis CM, Hanson C, Rishi RG, Wang X, Gjertson D, Yang OO, Balamurugan A, Bauer G, Ireland JA, Engel BC, Podsakoff GM, Hershfield MS, Blaese RM, Parkman R, Kohn DB. Blood. 2012 Nov 1;120(18):3635-46. doi: 10.1182/blood-2012-02-400937. Epub 2012 Sep 11. View abstract here

Gene therapy/bone marrow transplantation in ADA-deficient mice: roles of enzyme-replacement therapy and cytoreduction. Carbonaro DA, Jin X, Wang X, Yu XJ, Rozengurt N, Kaufman ML, Wang X, Gjertson D, Zhou Y, Blackburn MR, Kohn DB. Blood. 2012 Nov 1;120(18):3677-87. doi: 10.1182/blood-2012-02-408591. Epub 2012 Jul 25. View abstract here

Serum creatinine detection by a conducting-polymer-based electrochemical sensor to identify allograft dysfunction. Wei F, Cheng S, Korin Y, Reed EF, Gjertson D, Ho CM, Gritsch HA, Veale J. Anal Chem. 2012 Sep 18;84(18):7933-7. doi: 10.1021/ac3016888. Epub 2012 Aug 24. View abstract here

PubMed: David Gjertson


Glasgow, Ben, MD

Antibacterial activity of rifamycins for M. smegmatis with comparison of oxidation and binding to tear lipocalin. Staudinger T, Redl B, Glasgow BJ. Biochim Biophys Acta. 2014 Apr;1844(4):750-8. doi: 10.1016/j.bbapap.2014.02.001. Epub 2014 Feb 12.

Hereditary Benign Intraepithelial Dyskeratosis: Report of a Case and Re-examination of the Evidence for Locus Heterogeneity. Bui T, Young JW, Frausto RF, Markello TC, Glasgow BJ, Aldave AJ. Ophthalmic Genet. 2014 Feb 20.

Probing tertiary structure of proteins using single Trp mutations with circular dichroism at low temperature. Gasymov OK, Abduragimov AR, Glasgow BJ. J Phys Chem B. 2014 Jan 30;118(4):986-95. doi: 10.1021/jp4120145. Epub 2014 Jan 17.

A Simple Model-Free Method for Direct Assessment of Fluorescent Ligand Binding by Linear Spectral Summation. Gasymov OK, Abduragimov AR, Glasgow BJ. J Fluoresc. 2013 Sep 18. View abstract here

A novel fluorescent lipid probe for dry eye: retrieval by tear lipocalin in humans. Yeh PT, Casey R, Glasgow BJ. Invest Ophthalmol Vis Sci. 2013 Feb 19;54(2):1398-410. doi: 10.1167/iovs.12-10817. View abstract here

Contact lens care and ocular surface homeostasis. Efron N, Brennan NA, Bright FV, Glasgow BJ, Jones LW, Sullivan DA, Tomlinson A, Zhang J. Cont Lens Anterior Eye. 2013 Jan 15;36 Suppl 1:S9-13. doi: 10.1016/S1367-0484(13)60004-1. View abstract here

Tryptophan rotamer distribution revealed for the α-helix in tear lipocalin by site-directed tryptophan fluorescence. Gasymov OK, Abduragimov AR, Glasgow BJ. J Phys Chem B. 2012 Nov 15;116(45):13381-8. doi: 10.1021/jp309318r. Epub 2012 Nov 2. View abstract here

Parotidectomy and neck dissection in the management of conjunctival melanoma: are they necessary? Vira D, Pesce J, Glasgow BJ, Lai C, Elashoff D, Abemayor E, John MS. Laryngoscope. 2012 Nov;122(11):2436-41. doi: 10.1002/lary.23239. Epub 2012 Sep 24. View abstract here

Microbiologic and histopathologic assessment of corneal biopsies in the evaluation of microbial keratitis. Younger JR, Johnson RD, Holland GN, Page JP, Nepomuceno RL, Glasgow BJ, Aldave AJ, Yu F, Litak J, Mondino BJ; UCLA Cornea Service. Am J Ophthalmol. 2012 Sep;154(3):512-519.e2. doi: 10.1016/j.ajo.2012.03.014. Epub 2012 May 23. View abstract here

Cation-π interactions in lipocalins: structural and functional implications. Gasymov OK, Abduragimov AR, Glasgow BJ. Biochemistry. 2012 Apr 10;51(14):2991-3002. doi: 10.1021/bi3002902. Epub 2012 Mar 28. View abstract here

Mass spectrometric identification of phospholipids in human tears and tear lipocalin. Dean AW, Glasgow BJ. Invest Ophthalmol Vis Sci. 2012 Apr 2;53(4):1773-82. doi: 10.1167/iovs.11-9419. View abstract here

PubMed: Ben Glasgow


Grody, Wayne, MD, PhD

A Case of Mycosis Fungoides Transmitted From Donor to Recipient, and Review of Literature of T-Cell Malignancies After Transplantation. Loh JC, Cassarino DS, Grody WW, Chiu MW, Pinter-Brown LC. Clin Lymphoma Myeloma Leuk. 2014 Feb 17. pii: S2152-2650(14)00047-0. doi: 10.1016/j.clml.2014.02.005.

Assessing the necessity of confirmatory testing for exome-sequencing results in a clinical molecular diagnostic laboratory. Strom SP, Lee H, Das K, Vilain E, Nelson SF, Grody WW, Deignan JL. Genet Med. 2014 Jan 9. doi: 10.1038/gim.2013.183.

Whole-exome/genome sequencing and genomics. Grody WW, Thompson BH, Hudgins L. Pediatrics. 2013 Dec;132(Suppl 3):S211-5. doi: 10.1542/peds.2013-1032E.

Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse. Kasten J, Hu C, Bhargava R, Park H, Tai D, Byrne JA, Marescau B, De Deyn PP, Schlichting L, Grody WW, Cederbaum SD, Lipshutz GS. Mol Genet Metab. 2013 Nov;110(3):222-230. doi: 10.1016/j.ymgme.2013.06.020. Epub 2013 Jul 6. View abstract here

Carrier screening for cystic fibrosis in the new era of medications that restore CFTR function. Massie J, Castellani C, Grody WW. Lancet. 2013 Aug 29. doi:pii: S0140-6736(13)61092-2. 10.1016/S0140-6736(13)61092-2. View abstract here

AAV-based gene therapy prevents neuropathology and results in normal cognitive development in the hyperargininemic mouse. Lee EK, Hu C, Bhargava R, Ponnusamy R, Park H, Novicoff S, Rozengurt N, Marescau B, De Deyn P, Stout D, Schlichting L, Grody WW, Cederbaum SD, Lipshutz GS. Gene Ther. 2013 Aug;20(8):785-96. doi: 10.1038/gt.2012.99. Epub 2013 Feb 7. View abstract here

Current landscape and new paradigms of proficiency testing and external quality assessment for molecular genetics. Kalman LV, Lubin IM, Barker S, du Sart D, Elles R, Grody WW, Pazzagli M, Richards S, Schrijver I, Zehnbauer B. Arch Pathol Lab Med. 2013 Jul;137(7):983-8. doi: 10.5858/arpa.2012-0311-RA. View abstract here

The M694V mutation in Armenian-Americans: a 10-year retrospective study of MEFV mutation testing for familial Mediterranean fever at UCLA. Ong FS, Vakil H, Xue Y, Kuo JZ, Shah KH, Lee RB, Bernstein KE, Rimoin DL, Getzug T, Das K, Deignan JL, Rotter JI, Grody WW. Clin Genet. 2013 Jul;84(1):55-9. doi: 10.1111/cge.12029. Epub 2012 Nov 7. View abstract here

ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Green RC, Berg JS, Grody WW, Kalia SS, Korf BR, Martin CL, McGuire AL, Nussbaum RL, O'Daniel JM, Ormond KE, Rehm HL, Watson MS, Williams MS, Biesecker LG. Genet Med. 2013 Jun 20. doi: 10.1038/gim.2013.73. View abstract here

ACMG position statement on prenatal/preconception expanded carrier screening. Grody WW, Thompson BH, Gregg AR, Bean LH, Monaghan KG, Schneider A, Lebo RV. Genet Med. 2013 Jun;15(6):482-3. doi: 10.1038/gim.2013.47. Epub 2013 Apr 25. View abstract here

Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. Norton N, Li D, Rampersaud E, Morales A, Martin ER, Zuchner S, Guo S, Gonzalez M, Hedges DJ, Robertson PD, Krumm N, Nickerson DA, Hershberger RE; National Heart, Lung, and Blood Institute GO Exome Sequencing Project and the Exome Sequencing Project Family Studies Project Team. Circ Cardiovasc Genet. 2013 Apr;6(2):144-53. doi: 10.1161/CIRCGENETICS.111.000062. Epub 2013 Feb 15. View abstract here

Deaf Genetic Testing and Psychological Well-Being in Deaf Adults. Palmer CG, Boudreault P, Baldwin EE, Fox M, Deignan JL, Kobayashi Y, Sininger Y, Grody W, Sinsheimer JS. J Genet Couns. 2013 Feb 21. View abstract here

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Fu W, O'Connor TD, Jun G, Kang HM, Abecasis G, Leal SM, Gabriel S, Altshuler D, Shendure J, Nickerson DA, Bamshad MJ; NHLBI Exome Sequencing Project, Akey JM. Nature. 2013 Jan 10;493(7431):216-20. doi: 10.1038/nature11690. Epub 2012 Nov 28. View abstract here

Human Variome Project country nodes: documenting genetic information within a country. Patrinos GP, Smith TD, Howard H, Al-Mulla F, Chouchane L, Hadjisavvas A, Hamed SA, Li XT, Marafie M, Ramesar RS, Ramos FJ, de Ravel T, El-Ruby MO, Shrestha TR, Sobrido MJ, Tadmouri G, Witsch-Baumgartner M, Zilfalil BA, Auerbach AD, Carpenter K, Cutting GR, Dung VC, Grody W, Hasler J, Jorde L, Kaput J, Macek M, Matsubara Y, Padilla C, Robinson H, Rojas-Martinez A, Taylor GR, Vihinen M, Weber T, Burn J, Qi M, Cotton RG, Rimoin D; International Confederation of Countries Advisory Council. Hum Mutat. 2012 Nov;33(11):1513-9. doi: 10.1002/humu.22147. Epub 2012 Jul 18. View abstract here

Opportunities and challenges associated with clinical diagnostic genome sequencing: a report of the Association for Molecular Pathology. Schrijver I, Aziz N, Farkas DH, Furtado M, Gonzalez AF, Greiner TC, Grody WW, Hambuch T, Kalman L, Kant JA, Klein RD, Leonard DG, Lubin IM, Mao R, Nagan N, Pratt VM, Sobel ME, Voelkerding KV, Gibson JS. J Mol Diagn. 2012 Nov;14(6):525-40. doi: 10.1016/j.jmoldx.2012.04.006. Epub 2012 Aug 20. View abstract here

Long-term survival of the juvenile lethal arginase-deficient mouse with AAV gene therapy. Lee EK, Hu C, Bhargava R, Rozengurt N, Stout D, Grody WW, Cederbaum SD, Lipshutz GS. Mol Ther. 2012 Oct;20(10):1844-51. doi: 10.1038/mt.2012.129. Epub 2012 Jul 3. View abstract here

TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome. Boileau C, Guo DC, Hanna N, Regalado ES, Detaint D, Gong L, Varret M, Prakash SK, Li AH, d'Indy H, Braverman AC, Grandchamp B, Kwartler CS, Gouya L, Santos-Cortez RL, Abifadel M, Leal SM, Muti C, Shendure J, Gross MS, Rieder MJ, Vahanian A, Nickerson DA, Michel JB; National Heart, Lung, and Blood Institute (NHLBI) Go Exome Sequencing Project, Jondeau G, Milewicz DM. Nat Genet. 2012 Jul 8;44(8):916-21. doi: 10.1038/ng.2348. View abstract here

Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, Knowles MR, Wright FA, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC; National Heart, Lung, and Blood Institute (NHLBI) GO Exome Sequencing Project; Lung GO, Gibson RL, Bamshad MJ. Nat Genet. 2012 Jul 8;44(8):886-9. doi: 10.1038/ng.2344. View abstract here

Personalized medicine and pharmacogenetic biomarkers: progress in molecular oncology testing. Ong FS, Das K, Wang J, Vakil H, Kuo JZ, Blackwell WL, Lim SW, Goodarzi MO, Bernstein KE, Rotter JI, Grody WW. Expert Rev Mol Diagn. 2012 Jul;12(6):593-602. doi: 10.1586/erm.12.59. View abstract here

A report template for molecular genetic tests designed to improve communication between the clinician and laboratory. Scheuner MT, Hilborne L, Brown J, Lubin IM; members of the RAND Molecular Genetic Test Report Advisory Board. Genet Test Mol Biomarkers. 2012 Jul;16(7):761-9. doi: 10.1089/gtmb.2011.0328. Epub 2012 Jun 25. View abstract here

Exploring concordance and discordance for return of incidental findings from clinical sequencing. Green RC, Berg JS, Berry GT, Biesecker LG, Dimmock DP, Evans JP, Grody WW, Hegde MR, Kalia S, Korf BR, Krantz I, McGuire AL, Miller DT, Murray MF, Nussbaum RL, Plon SE, Rehm HL, Jacob HJ. Genet Med. 2012 Apr;14(4):405-10. doi: 10.1038/gim.2012.21. Epub 2012 Mar 15. View abstract here

Stuck between a scalpel and a rock, or molecular pathology and legal-ethical issues in use of tissues for clinical care and research: what must a pathologist know? Dry S, Grody WW, Papagni P. Am J Clin Pathol. 2012 Mar;137(3):346-55. doi: 10.1309/AJCPS26UKHNYCEAV. View abstract here

DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as Down syndrome: an international collaborative study. Palomaki GE, Deciu C, Kloza EM, Lambert-Messerlian GM, Haddow JE, Neveux LM, Ehrich M, van den Boom D, Bombard AT, Grody WW, Nelson SF, Canick JA. Genet Med. 2012 Mar;14(3):296-305. doi: 10.1038/gim.2011.73. Epub 2012 Feb 2. View abstract here

Clinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementation. Ong FS, Deignan JL, Kuo JZ, Bernstein KE, Rotter JI, Grody WW, Das K. Pharmacogenomics. 2012 Mar;13(4):465-75. doi: 10.2217/pgs.12.2. View abstract here

PubMed: Wayne Grody


Hankinson, Oliver, PhD

Genome-Wide RNAi High-Throughput Screen Identifies Proteins Necessary for the AHR-Dependent Induction of CYP1A1 by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Solaimani P, Damoiseaux R, Hankinson O. Toxicol Sci. 2013 Oct 8. View abstract here

Potential Role of Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport. Ingelman-Sundberg M, Zhong XB, Hankinson O, Beedanagari S, Yu AM, Peng L, Osawa Y. Drug Metab Dispos. 2013 Oct;41(10):1725-1731. Epub 2013 Aug 5. View abstract here

HIF-1 expression is associated with CCL2 chemokine expression in airway inflammatory cells: implications in allergic airway inflammation. Baay-Guzman GJ, Bebenek IG, Zeidler M, Hernandez-Pando R, Vega MI, Garcia-Zepeda EA, Antonio-Andres G, Bonavida B, Riedl M, Kleerup E, Tashkin DP, Hankinson O, Huerta-Yepez S. Respir Res. 2012 Jul 23;13:60. doi: 10.1186/1465-9921-13-60. View abstract here

2,3,7,8-Tetrachlorodibenzo-p-dioxin treatment alters eicosanoid levels in several organs of the mouse in an aryl hydrocarbon receptor-dependent fashion. Bui P, Solaimani P, Wu X, Hankinson O. Toxicol Appl Pharmacol. 2012 Mar 1;259(2):143-51. doi: 10.1016/j.taap.2011.12.009. Epub 2011 Dec 20. View abstract here

CYP2S1 is negatively regulated by corticosteroids in human cell lines. Bebenek IG, Solaimani P, Bui P, Hankinson O. Toxicol Lett. 2012 Feb 25;209(1):30-4. doi: 10.1016/j.toxlet.2011.11.020. Epub 2011 Nov 30. View abstract here

The transcription factor encyclopedia. Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. Genome Biol. 2012;13(3):R24. doi: 10.1186/gb-2012-13-3-r24. View abstract here

PubMed: Oliver Hankinson


Hirschowitz, Sharon, MD

Significance of the diagnostic categories "atypical" and "suspicious for malignancy" in the cytologic diagnosis of solid pancreatic masses. Layfield LJ, Schmidt RL, Hirschowitz SL, Olson MT, Ali SZ, Dodd LL. Diagn Cytopathol. 2014 Apr;42(4):292-6. doi: 10.1002/dc.23078. Epub 2014 Feb 28.

Pleural fluid metastases of salivary duct carcinoma: A case report and review of the literature. Huss J Md, Conrad R Md, Hirschowitz S Md, Moatamed N Md. Cytojournal. 2014 Feb 15;11:4. eCollection 2014.

Juvenile granulosa cell tumors: immunoreactivity for CD99 and Fli-1 and EWSR1 translocation status: a study of 11 cases. Jarboe EA, Hirschowitz SL, Geiersbach KB, Wallander ML, Tripp SR, Layfield LJ. Int J Gynecol Pathol. 2014 Jan;33(1):11-5. doi: 10.1097/PGP.0b013e31828309e6.

Hints to the diagnosis of mixed acinar-endocrine carcinoma on pancreatic fine-needle aspiration: avoiding a potential diagnostic pitfall. Sullivan PS, Clebanoff JL, Hirschowitz SL. Acta Cytol. 2013;57(3):296-302. doi: 10.1159/000343683. Epub 2013 Apr 25. View abstract here

Respiratory cytology in the era of molecular diagnostics: a review. Witt BL, Wallander ML, Layfield LJ, Hirschowitz S. Diagn Cytopathol. 2012 Jun;40(6):556-63. doi: 10.1002/dc.22858. View abstract here

PubMed: Sharon Hirschowitz


Kelly, Kathleen, PhD

 

The Influence of Serum Separator Tubes on Mycophenolic Acid Concentrations Determined by HPLC. Alberti MO, Fukuchi AM, Kelly KA. Ther Drug Monit. 2014 Apr 8.

Early growth response 3 (Egr-3) is induced by transforming growth factor-β and regulates fibrogenic responses. Fang F, Shangguan AJ, Kelly K, Wei J, Gruner K, Ye B, Wang W, Bhattacharyya S, Hinchcliff ME, Tourtellotte WG, Varga J. Am J Pathol. 2013 Oct;183(4):1197-208. doi: 10.1016/j.ajpath.2013.06.016. Epub 2013 Jul 30.

DACT1, an antagonist to Wnt/beta-catenin signaling, suppresses tumor cell growth and is frequently silenced in breast cancer. Ying X, Xiang T, Li L, Su X, Shu X, Luo X, Huang J, Yuan Y, Peng W, Oberst M, Kelly K, Ren G, Tao Q. Breast Cancer Res. 2013 Mar 12;15(2):R23. View abstract here

CD8?CXCR5? T cells regulate pathology in the genital tract. Jiang J, Champion CI, Wei B, Liu G, Kelly KA. Infect Dis Obstet Gynecol. 2013;2013:813238. doi: 10.1155/2013/813238. Epub 2013 Jan 10. View abstract here

Isolation of lymphocytes from mouse genital tract mucosa. Jiang J, Kelly KA. J Vis Exp. 2012 Sep 3;(67):e4391. doi: 10.3791/4391. View abstract here

PubMed: Kathleen Kelly


Khanlou, Negar, MD

Lyophilized brain tumor specimens can be used for histologic, nucleic acid, and protein analyses after 1 year of room temperature storage. Mareninov S, De Jesus J, Sanchez DE, Kay AB, Wilson RW, Babic I, Chen W, Telesca D, Lou JJ, Mirsadraei L, Gardner TP, Khanlou N, Vinters HV, Shafa BB, Lai A, Liau LM, Mischel PS, Cloughesy TF, Yong WH. J Neurooncol. 2013 Jul;113(3):365-73. doi: 10.1007/s11060-013-1135-1. Epub 2013 May 3. View abstract here

Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcome. Lalezari S, Chou AP, Tran A, Solis OE, Khanlou N, Chen W, Li S, Carrillo JA, Chowdhury R, Selfridge J, Sanchez DE, Wilson RW, Zurayk M, Lalezari J, Lou JJ, Ormiston L, Ancheta K, Hanna R, Miller P, Piccioni D, Ellingson BM, Buchanan C, Mischel PS, Nghiemphu PL, Green R, Wang HJ, Pope WB, Liau LM, Elashoff RM, Cloughesy TF, Yong WH, Lai A. Neuro Oncol. 2013 Mar;15(3):370-81. doi: 10.1093/neuonc/nos308. Epub 2013 Jan 17. View abstract here

The homozygote VCP(R¹55H/R¹55H) mouse model exhibits accelerated human VCP-associated disease pathology. Nalbandian A, Llewellyn KJ, Kitazawa M, Yin HZ, Badadani M, Khanlou N, Edwards R, Nguyen C, Mukherjee J, Mozaffar T, Watts G, Weiss J, Kimonis VE. PLoS One. 2012;7(9):e46308. doi: 10.1371/journal.pone.0046308. Epub 2012 Sep 28. View abstract here

PubMed: Negar Khanlou


Kupiec-Weglinski, Jerzy W., MD, PhD


Myeloid PTEN Deficiency Protects Livers from Ischemia Reperfusion Injury by Facilitating M2 Macrophage Differentiation. Yue S, Rao J, Zhu J, Busuttil RW, Kupiec-Weglinski JW, Lu L, Wang X, Zhai Y. J Immunol. 2014 Apr 25.

KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants. Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. J Hepatol. 2013 Jul 16. doi:pii: S0168-8278(13)00463-7. 10.1016/j.jhep.2013.07.016. View abstract here

Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo. Valenzuela NM, Hong L, Shen XD, Gao F, Young SH, Rozengurt E, Kupiec-Weglinski JW, Fishbein MC, Reed EF. Am J Transplant. 2013 Feb;13(2):299-311. doi: 10.1111/ajt.12016. Epub 2012 Dec 27. View abstract here

Targeting TIM-1 on CD4 T cells depresses macrophage activation and overcomes ischemia-reperfusion injury in mouse orthotopic liver transplantation. Zhang Y, Ji H, Shen X, Cai J, Gao F, Koenig KM, Batikian CM, Busuttil RW, Kupiec-Weglinski JW. Am J Transplant. 2013 Jan;13(1):56-66. doi: 10.1111/j.1600-6143.2012.04316.x. Epub 2012 Nov 8. View abstract here

Disruption of Type-I IFN pathway ameliorates preservation damage in mouse orthotopic liver transplantation via HO-1 dependent mechanism. Shen XD, Ke B, Ji H, Gao F, Freitas MC, Chang WW, Lee C, Zhai Y, Busuttil RW, Kupiec-Weglinski JW. Am J Transplant. 2012 Jul;12(7):1730-9. doi: 10.1111/j.1600-6143.2012.04021.x. Epub 2012 Mar 19. View abstract here

Regulated hepatic reperfusion mitigates ischemia-reperfusion injury and improves survival after prolonged liver warm ischemia: a pilot study on a novel concept of organ resuscitation in a large animal model. Hong JC, Koroleff D, Xia V, Chang CM, Duarte SM, Xu J, Lassman C, Kupiec-Weglinski J, Coito AJ, Busuttil RW. J Am Coll Surg. 2012 Apr;214(4):505-15; discussion 515-6. doi: 10.1016/j.jamcollsurg.2011.12.010. Epub 2012 Feb 7. View abstract here

HO-1-STAT3 axis in mouse liver ischemia/reperfusion injury: regulation of TLR4 innate responses through PI3K/PTEN signaling. Ke B, Shen XD, Ji H, Kamo N, Gao F, Freitas MC, Busuttil RW, Kupiec-Weglinski JW. J Hepatol. 2012 Feb;56(2):359-66. doi: 10.1016/j.jhep.2011.05.023. Epub 2011 Jul 12. View abstract here

PubMed: Jerzy W. Kupiec-Weglinski


Kurdistani, Siavash, MD

Histone acetylation regulates intracellular pH. McBrian MA, Behbahan IS, Ferrari R, Su T, Huang TW, Li K, Hong CS, Christofk HR, Vogelauer M, Seligson DB, Kurdistani SK. Mol Cell. 2013 Jan 24;49(2):310-21. doi: 10.1016/j.molcel.2012.10.025. Epub 2012 Nov 29. View abstract here

Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function. Chen XF, Lehmann L, Lin JJ, Vashisht A, Schmidt R, Ferrari R, Huang C, McKee R, Mosley A, Plath K, Kurdistani SK, Wohlschlegel J, Carey M. Cell Rep. 2012 Nov 29;2(5):1061-7. doi: 10.1016/j.celrep.2012.10.019. Epub 2012 Nov 21. View abstract here

Polycomb repressive complex 1 (PRC1) disassembles RNA polymerase II preinitiation complexes. Lehmann L, Ferrari R, Vashisht AA, Wohlschlegel JA, Kurdistani SK, Carey M. J Biol Chem. 2012 Oct 19;287(43):35784-94. doi: 10.1074/jbc.M112.397430. Epub 2012 Aug 21. View abstract here

Stimulation of histone deacetylase activity by metabolites of intermediary metabolism. Vogelauer M, Krall AS, McBrian MA, Li JY, Kurdistani SK. J Biol Chem. 2012 Sep 14;287(38):32006-16. doi: 10.1074/jbc.M112.362467. Epub 2012 Jul 20. View abstract here

Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK. Cell. 2012 Aug 3;150(3):590-605. doi: 10.1016/j.cell.2012.06.026. View abstract here

Reorganization of the host epigenome by a viral oncogene. Ferrari R, Su T, Li B, Bonora G, Oberai A, Chan Y, Sasidharan R, Berk AJ, Pellegrini M, Kurdistani SK. Genome Res. 2012 Jul;22(7):1212-21. doi: 10.1101/gr.132308.111. Epub 2012 Apr 12. View abstract here

PubMed: Siavash Kurdistani

 


Li, Xinmin, MD

De novo single exon deletion of AUTS2 in a patient with speech and language disorder: a review of disrupted AUTS2 and further evidence for its role in neurodevelopmental disorders. Amarillo IE, Li WL, Li X, Vilain E, Kantarci S. Am J Med Genet A. 2014 Apr;164A(4):958-65. doi: 10.1002/ajmg.a.36393. Epub 2014 Jan 23.

Differentiating cutaneous squamous cell carcinoma and pseudoepitheliomatous hyperplasia by multiplex qRT-PCR. Su A, Ra S, Li X, Zhou J, Binder S. Mod Pathol. 2013 May 24. doi: 10.1038/modpathol.2013.82. View abstract here

Preferential biological processes in the human limbus by differential gene profiling. Nakatsu MN, Vartanyan L, Vu DM, Ng MY, Li X, Deng SX. PLoS One. 2013 Apr 22;8(4):e61833. doi: 10.1371/journal.pone.0061833. Print 2013. View abstract here

Pilot study on "pericytic mimicry" and potential embryonic/stem cell properties of angiotropic melanoma cells interacting with the abluminal vascular surface. Lugassy C, Wadehra M, Li X, Corselli M, Akhavan D, Binder SW, Péault B, Cochran AJ, Mischel PS, Kleinman HK, Barnhill RL. Cancer Microenviron. 2013 Apr;6(1):19-29. doi: 10.1007/s12307-012-0128-5. Epub 2012 Dec 29. View abstract here

Molecularly enriched pathways and differentially expressed genes distinguishing cutaneous squamous cell carcinoma from pseudoepitheliomatous hyperplasia. Ra SH, Su A, Li X, Binder S. Diagn Mol Pathol. 2013 Mar;22(1):41-7. doi: 10.1097/PDM.0b013e3182707894. View abstract here

Genetic Profiling of BRAF Inhibitor-Induced Keratoacanthomas Reveals No Induction of MAP Kinase Pathway Expression. Kulkarni RP, Plaisier S, Ra SH, Li X, Lee DJ, Hillman JD, Binder SW. J Invest Dermatol. 2013 Mar;133(3):830-3. doi: 10.1038/jid.2012.353. Epub 2012 Sep 27. View abstract here

HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma. Nguyen Kovochich A, Arensman M, Lay AR, Rao NP, Donahue T, Li X, French SW, Dawson DW. Cancer. 2013 Feb 1;119(3):529-39. doi: 10.1002/cncr.27725. Epub 2012 Aug 22. View abstract here

Dynamic expression of small RNA populations in larch (Larix leptolepis). Zhang J, Wu T, Li L, Han S, Li X, Zhang S, Qi L. Planta. 2013 Jan;237(1):89-101. doi: 10.1007/s00425-012-1753-4. Epub 2012 Sep 16. View abstract here

Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability. Magnusson M, Sierra MI, Sasidharan R, Prashad SL, Romero M, Saarikoski P, Van Handel B, Huang A, Li X, Mikkola HK. PLoS One. 2013;8(1):e53912. doi: 10.1371/journal.pone.0053912. Epub 2013 Jan 16. View abstract here

A genome-wide survey of microRNA truncation and 3' nucleotide addition events in larch (Larix leptolepis). Zhang J, Zhang S, Li S, Han S, Wu T, Li X, Qi L. Planta. 2012 Dec 12. View abstract here

Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages. He H, Xu J, Warren CM, Duan D, Li X, Wu L, Iruela-Arispe ML. Blood. 2012 Oct 11;120(15):3152-62. doi: 10.1182/blood-2012-04-422758. Epub 2012 Aug 23. View abstract here

Hepatitis B virus directly promotes collagen I expression of LX-2 cells without infection in vitro. Wu X, Wang Y, Cui Y, Bai Q, Ze X, Liu T, Cong M, Wang P, Li X, Yin G, Ou X, You H, Jia J. Hepatol Res. 2012 Sep;42(9):911-21. doi: 10.1111/j.1872-034X.2012.01000.x. Epub 2012 Apr 23. View abstract here

Transcriptome profiling and in silico analysis of somatic embryos in Japanese larch (Larix leptolepis). Zhang Y, Zhang S, Han S, Li X, Qi L. Plant Cell Rep. 2012 Sep;31(9):1637-57. doi: 10.1007/s00299-012-1277-1. Epub 2012 May 24. View abstract here

Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells. Zhang M, Mathur A, Zhang Y, Xi S, Atay S, Hong JA, Datrice N, Upham T, Kemp CD, Ripley RT, Wiegand G, Avital I, Fetsch P, Mani H, Zlott D, Robey R, Bates SE, Li X, Rao M, Schrump DS. Cancer Res. 2012 Aug 15;72(16):4178-92. doi: 10.1158/0008-5472.CAN-11-3983. Epub 2012 Jul 2. View abstract here

Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK. Cell. 2012 Aug 3;150(3):590-605. doi: 10.1016/j.cell.2012.06.026. View abstract here

Genome-wide identification of microRNAs in larch and stage-specific modulation of 11 conserved microRNAs and their targets during somatic embryogenesis. Zhang J, Zhang S, Han S, Wu T, Li X, Li W, Qi L. Planta. 2012 Aug;236(2):647-57. doi: 10.1007/s00425-012-1643-9. Epub 2012 Apr 13. View abstract here

Differential gene expression profiling of primary cutaneous melanoma and sentinel lymph node metastases. Koh SS, Wei JP, Li X, Huang RR, Doan NB, Scolyer RA, Cochran AJ, Binder SW. Mod Pathol. 2012 Jun;25(6):828-37. doi: 10.1038/modpathol.2012.32. Epub 2012 Mar 9. View abstract here

Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway. Chen H, Sun Y, Wu C, Magyar CE, Li X, Cheng L, Yao JL, Shen S, Osunkoya AO, Liang C, Huang J. Endocr Relat Cancer. 2012 May 24;19(3):321-31. doi: 10.1530/ERC-11-0368. Print 2012 Jun. View abstract here

PubMed: Xinmin Li


Lu, David, MD

Efficacy of the American Association for the Study of Liver Disease and Barcelona criteria for the diagnosis of hepatocellular carcinoma. Pahwa A, Beckett K, Channual S, Tan N, Lu DS, Raman SS. Abdom Imaging. 2014 Apr 4. [Epub ahead of print]

Safety of Hydroinfusion in Percutaneous Thermal Ablation of Hepatic Malignancies. McWilliams JP, Plotnik AN, Sako EY, Raman SS, Tan N, Siripongsakun S, Douek M, Lu DS. J Vasc Interv Radiol. 2014 Mar 3. pii: S1051-0443(13)02344-0. doi: 10.1016/j.jvir.2013.12.562. [Epub ahead of print]

Assessment of chronological effects of irreversible electroporation on hilar bile ducts in a porcine model. Choi JW, Lu DS, Osuagwu F, Raman S, Lassman C. Cardiovasc Intervent Radiol. 2014 Feb;37(1):224-30. doi: 10.1007/s00270-013-0731-y. Epub 2013 Nov 7.

Evaluation of alpha-fetoprotein in detecting hepatocellular carcinoma recurrence after radiofrequency ablation. Siripongsakun S, Wei SH, Lin S, Chen J, Raman SS, Sayre J, Tong MJ, Lu DS. J Gastroenterol Hepatol. 2014 Jan;29(1):157-64. doi: 10.1111/jgh.12438.

Cellular Mechanisms of Tissue Fibrosis. 7. Purinergic signaling and response in fibroblasts and tissue fibrosis. Lu D, Insel PA. Am J Physiol Cell Physiol. 2013 Dec 18. [Epub ahead of print]

Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Lu D, Aroonsakool N, Yokoyama U, Patel HH, Insel PA. Mol Pharmacol. 2013 Dec;84(6):787-93. doi: 10.1124/mol.113.087742. Epub 2013 Oct 1.

Irreversible electroporation: ready for prime time? Lu DS, Kee ST, Lee EW. Tech Vasc Interv Radiol. 2013 Dec;16(4):277-86. doi: 10.1053/j.tvir.2013.08.010.

Efficacy of imaging-guided percutaneous radiofrequency ablation for the treatment of biopsy-proven malignant cystic renal masses. Felker ER, Lee-Felker SA, Alpern L, Lu D, Raman SS. AJR Am J Roentgenol. 2013 Nov;201(5):1029-35. doi: 10.2214/AJR.12.10210.

Utility of ProEx C in the histologic evaluation of the neoplastic and nonneoplastic urothelial lesions. Moatamed NA, Vergara-Lluri ME, Lu D, Apple SK, Kerkoutian S, Rao JY. Hum Pathol. 2013 Nov;44(11):2509-17. doi: 10.1016/j.humpath.2013.06.011. Epub 2013 Sep 9.

Doppler US for Suspicion of Hepatic Arterial Ischemia in Orthotopically Transplanted Livers: Role of Central versus Intrahepatic Waveform Analysis. Choi EK, Lu DS, Park SH, Hong JC, Raman SS, Ragavendra N. Radiology. 2013 Apr;267(1):276-84. doi: 10.1148/radiol.12120557. Epub 2013 Jan 7. View abstract here

Irreversible electroporation in porcine liver: acute computed tomography appearance of ablation zone with histopathologic correlation. Lee YJ, Lu DS, Osuagwu F, Lassman C. J Comput Assist Tomogr. 2013 Mar;37(2):154-8. doi: 10.1097/RCT.0b013e31827dbf9b. View abstract here

Complete tumor encapsulation on magnetic resonance imaging: A potentially useful imaging biomarker for better survival in solitary large hepatocellular carcinoma. Lu DS, Siripongsakun S, Kyong Lee J, Wei SH, Cheng PM, Sabounchi S, Lee JS, Raman S, Tong MJ, Busuttil RW, Sayre J. Liver Transpl. 2013 Mar;19(3):283-91. doi: 10.1002/lt.23597. View abstract here

ProEx C as an adjunct marker to improve cytological detection of urothelial carcinoma in urinary specimens. Moatamed NA, Rao JY, Alexanian S, Cobarrubias M, Levin M, Lu D, Apple SK. Cancer Cytopathol. 2013 Jan 30. doi: 10.1002/cncy.21264. View abstract here

MRI detection of intratumoral fat in hepatocellular carcinoma: potential biomarker for a more favorable prognosis. Siripongsakun S, Lee JK, Raman SS, Tong MJ, Sayre J, Lu DS. AJR Am J Roentgenol. 2012 Nov;199(5):1018-25. doi: 10.2214/AJR.12.8632. View abstract here

Irreversible electroporation in porcine liver: short- and long-term effect on the hepatic veins and adjacent tissue by CT with pathological correlation. Lee YJ, Lu DS, Osuagwu F, Lassman C. Invest Radiol. 2012 Nov;47(11):671-5. doi: 10.1097/RLI.0b013e318274b0df. View abstract here

PubMed: David Lu