The TCGB occupies approximately 2,568 square feet of laboratory space on the third floor of the Center for Health Sciences, CHS 38-123, 38-126 and 33-388. It is operated by seventeen experienced genomic scientists. The TCGB is a high throughput genomic center utilizing the equipment listed below. In addition to offering wet-lab services, the TCGB has developed a broad informatics infrastructure and an efficient means for data acquisition, storage, and analysis. We have access to advanced software including Partek flow, VarSeq, and Falcon automated system, which significantly enhance the overall capacity of TCGB to rapidly process and transform the large quantity of data into novel findings.

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Equipment

Next-Generation Sequencing

OxfordNANOPORE GriDIONx5 Sequencing System
10X Genomics Chromium™ Controller Single Cell Sequencing System
10x Genomics Chromium Connect
GeoMx DSP (Nanostring)
CosMx SMI (NanoString)
10X Visium
Visium HD
Xenium
StereoSeq
NovaSeqTM X Plus Sequencing System
Illumina NextSeq 500 Sequencing System
Illumina MiSeq Personal Sequencer System
IntegenX Apollo 324 for automated NGS library preparation
Beckman Coulter BioMek i7 for fully automated workstation
Fluidigm Access Array System for target-enrichment
Covaris M220 for DNA shearing

Nucleic Acid Isolation

Roche MagNa Lyzer instrument for automated tissue homogenization
Biochain AnaPrep Automated Nucleic Acid Preparation System
Qiagen QIAcube HT Automated mid- to high-throughput Nucleic Acid Purification System

Quality Control

Agilent 2100 Bioanalyzer
Agilent 2200 Tapestation
NanoDrop 8000
Qubit 3.0 Fluorometer
Fragment Analyzer
Varioskan Lux Plate Reader

Other

Applied Biosystems 7500 Fast Real-Time PCR System
Bio-Rad C1000 Touch Thermal Cycler
Thermo Scientific DNA120 Speedvac Concentrator

Data Analysis (Software) / Other Resources

Partek flow
VarSeq
Falcon automated genomic analysis system
Hoffman2 data analysis clusters
Illumina base space Sequencing Hub professional
Amazon cloud HIPAA compliant research computing and storage system