Publications

Jacobs JP, Gupta A, Bhatt RR, Brawer J, Gao K, Tillisch K, Lagishetty V, Firth R, Gudleski GD, Ellingson BM, Labus JS, Naliboff BD, Lackner JM, Mayer EA. Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvementMicrobiome. 30 November 2021


Jasinska AJ, Dong TS, Lagishetty V, Katzka W, Jacobs JP, Schmitt CA, Cramer JD, Ma D, Coetzer WG, Grobler JP, Turner TR, Freimer N, Pandrea I, Apetrei C. Shifts in microbial diversity, composition and functionality in the gut and genital microbiome during a natural SIV infection in vervet monkeysMicrobiome. 2020 Nov 6;8(1):154. [PMID: 33158452]


Volkmann ER, Hoffmann-Vold A, Chang Y, Lagishetty V, Clements PJ, Midtvedt O, Molberg O, Braun J, Jacobs JP. Longitudinal characterisation of the gastrointestinal tract microbiome in systemic sclerosisEMJ. 2020;5(4):110-118


Hung T, Dong T, Chen Z, Elashoff D, Sinsheimer JS, Jacobs JP, Lagishetty V, Vora P, Stains J, Mayer EA, Gupta A. Understanding the heterogeneity of obesity and the relationship to the brain-gut axisNutrients. 2020 Nov 30;12(12):3701. [PMID: 33266058]


Osadchiy V, Mayer EA, Gao K, Labus JS, Naliboff B, Tillisch K, Chang L, Jacobs JP, Hsiao EY, Gupta A. Analysis of brain networks and fecal metabolites reveals brain-gut alterations in premenopausal females with irritable bowel syndromeTransl Psychiatry. 2020 Nov 2;10(1):367. [PMID: 33139708]


Turkiewicz J, Bhatt RR, Wang H, Vora P, Krause B, Sauk JS, Jacobs JP, Bernstein CN, Kornelsen J, Labus JS, Gupta A, Mayer EA. Altered brain structural connectivity in patients with longstanding gut inflammation is correlated with psychological symptoms and disease durationNeuroimage Clin. 2021 Mar 9;30:102613. [PMID: 33823388]


Lee SM , Dong TS, Krause-Sorio B, Siddarth P , Milillo MM, Lagishetty V, Datta T, Aguilar-Faustino Y, Jacobs JP, Lavretsky H. The intestinal microbiota as a predictor for antidepressant treatment outcome in geriatric depression: a prospective pilot studyInt Psychogeriatr. 2021 Mar 24;1-13. [PMID: 33757609]


Dong TS, Luu K, Lagishetty V, Sedighian F, Woo S, Dreskin BW, Katzka W, Chang C, Zhou Y, Arias-Jayo N, Yang J, Ahdoot AI, Ye J, Li Z, Pisegna JR, Jacobs JP. Gut microbiome profiles associated with steatosis severity in metabolic associated fatty liver diseaseHepatoma Res. 2021;7:37


Dreskin BW, Luu K, Dong TS, Benhammou J, Lagishetty V, Vu J, Sanford D, Durazo F, Agopian VG, Jacobs JP, Pisegna JR, Hussain SK. Specimen collection and analysis of the duodenal microbiomeJ Vis Exp. 2021; 167: e61900. [PMID: 33522511]


Mazarati A, Medel-Matus J, Shin D, Jacobs JP, Sankar R. Disruption of intestinal barrier and endotoxemia after traumatic brain injury: Implications for post-traumatic epilepsyEpilepsia. 2021 Jun;62(6):1472-1481. [PMID: 33893636]


Lenhart A, Dong T, Joshi S, Jaffe N, Choo C, Liu C, Jacobs JP, Lagishetty V, Shih W, Labus J, Gupta A, Tillisch K, Mayer EA, Chang L. Effect of exclusion diets on symptom severity and the gut microbiota in patients with irritable bowel syndromeClin Gastroenterol Hepatol. 2021 May 19;S1542-3565(21)00565-6. [PMID: 34022450]


Coley EJL, Mayer EA, Osadchiy V, Chen Z, Subramanyam V, Zhang Y, Hsiao EY, Gao K, Bhatt R, Dong T, Vora P, Naliboff B, Jacobs JP, Gupta A. Early life adversity predicts brain-gut alterations associated with increased stress and moodNeurobiol Stress. 2021 May 25;15:100348. [PMID: 34113697]


Martinez JE, Kahana DD, Ghuman S, Wilson HP, Wilson J, Kim SCJ, Lagishetty V, Jacobs JP, Sinha-Hikim AP, Friedman TC. Unhealthy lifestyle and gut dysbiosis: A better understanding of the effects of poor diet and nicotine on the intestinal microbiomeFront Endocrinol. 2021 Jun 8;12:667066. [PMID: 34168615]


Fox M, Lee SM, Wiley KS, Lagishetty V, Sandman CA, Jacobs JP, Glynn LM. Development of the infant gut microbiome predicts temperament across the first year of lifeDev Psychopathol. 2021 Jun 10;1-12. [PMID: 34108055]


Dong TS, Luu K, Lagishetty V, Sedighian F, Woo S, Dreskin BW, Katzka W, Chang C, Zhou Y, Arias-Jayo N, Yang J, Ahdoot AI, Ye J, Li Z, Pisegna JR, Jacobs JP. The intestinal microbiome predicts weight loss on a calorie-restricted diet and is associated with improved hepatic steatosisFront Nutr. 2021 Jul 8;8:718661. [PMID: 34307440]


Shieh A, Lee SM, Lagishetty V, Gottleib C, Jacobs JP, Adams JS. Pilot trial of cholecalciferol and calcifediol in healthy vitamin D deficient adults: does it change the fecal microbiome? J Clin Endocrinol Metab. 2021 Aug 3;dgab573. [PMID: 34343292]


Jones JD, Dominguez D, Bunch J, Uribe C, Valenzuela Y, Jacobs JP. A bidirectional relationship between anxiety, depression and gastrointestinal symptoms in Parkinson’s diseaseClinical Parkinsonism & Related Disorders. 2021 Aug 10;5:100104. [PMID: 34430845]


Katzka W, Dong TS, Luu K, Lagishetty V, Sedighian F, Arias-Jayo N, Jacobs JP, Hsu HY. The ocular microbiome is altered by sampling modality and ageTransl Vis Sci Technol. 2021 Oct 4;10(12):24. [PMID: 34661621]


Chang CC, Huang ZY, Shih SH, Luo Y, Ko A, Cui Q, Sumner J, Cavallero S, Das S, Gao W, Sinsheimer J, Bui A, Jacobs JP, Pajukanta P, Wu H, Tai YC, Li Z, Hsiai TK. Electrical impedance tomography for non-invasive identification of fatty liver infiltrate in overweight individualsSci Rep. 2021 Oct 6;11(1):19859. [PMID: 34615918]


Mukherjee P, Chattopadhyay A, Girjalva V, Dorreh N, Lagishetty V, Jacobs JP, Clifford BL, Vallim T, Mack JJ, Navab M, Reddy ST, Fogelman AM. Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammationJ Lipid Res. 2021 Nov 19;100153. [PMID: 34808192]


Dong TS, Jacobs JP, Agopian V, Pisegna JR, Ayoub W, Durazo F, Enayati P, Sundaram V, Benhammou JN, Noureddin M, Choi G, Lagishetty V, Fiehn O, Goodman MT, Elashoff D, Hussain SK. Duodenal microbiome and serum metabolites predict hepatocellular carcinoma in a multicenter cohort of patients with cirrhosisDig Dis Sci. 2021 Nov 20. [PMID: 34799768]


Dreskin BW, Luu K, Dong TS, Benhammou J, Lagishetty V, Vu J, Sanford D, Durazo F, Agopian VG, Jacobs JP, Pisegna JR, Hussain SK. Specimen collection and analysis of the duodenal microbiomeJ Vis Exp. 2021; 167: e61900. [PMID: 33522511]


Martinez JE, Kahana DD, Ghuman S, Wilson HP, Wilson J, Kim SCJ, Lagishetty V, Jacobs JP, Sinha-Hikim AP, Friedman TC. Unhealthy lifestyle and gut dysbiosis: A better understanding of the effects of poor diet and nicotine on the intestinal microbiomeFront Endocrinol. 2021 Jun 8;12:667066. [PMID: 34168615]


Jasinska AJ, Dong TS, Lagishetty V, Katzka W, Jacobs JP, Schmitt CA, Cramer JD, Ma D, Coetzer WG, Grobler JP, Turner TR, Freimer N, Pandrea I, Apetrei C. Shifts in microbial diversity, composition and functionality in the gut and genital microbiome during a natural SIV infection in vervet monkeysMicrobiome, in press


Bergstrom K, Shan X, Casero D, Batushansky A, Lagishetty V, Jacobs JP, Hoover C, Kondo Y, Shao B, Gao L, Zandberg W, Noyovitz B, McDaniel JM, Gibson DL, Pakpour S, Kazemian N, McGee S, Houchen CW, Rao CV, Griffin TM, Sonnenburg JL, McEver RP, Braun J, Xia L. Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiotaScience. 2020 Oct 23;370(6515):467-472. [PMID: 33093110]


Dong TS, Luu K, Lagishetty V, Sedighian F, Woo S, Dreskin BW, Katzka W, Chang C, Zhou Y, Arias-Jayo N, Yang J, Ahdoot A, Li Z, Pisegna JR, Jacobs JP. A High Protein Calorie Restriction Diet Alters the Gut Microbiome in ObesityNutrients. 2020 Oct 21;12(10):3221. [PMID: 33096810]


Dong TS, Gupta A, Jacobs JP, Lagishetty V, Gallagher E, Bhatt RR, Vora P, Osadchiy V, Stains J, Balioukova A, Chen Y, Dutson E, Mayer EA, Sanmiguel C. Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese WomenNutrients. 2020 Sep 24;12(10):2924. [PMID: 32987837]


Dong TS, Mayer EA, Osadchiy V, Chang C, Katzka W, Lagishetty V, Gonzalez K, Kalani A, Stains J, Jacobs JP, Longo VD, Gupta A. A Distinct Brain-Gut Microbiome Profile Exists for Obese Females with Food AddictionObesity (Silver Spring). 2020 Aug;28(8):1477-1486. [PMID: 32935533]


Hussain SK, Dong TS, Agopian V, Pisegna JR, Durazo FA, Enayati P, Sundaram V, Benhammou JN, Noureddin M, Choi G, Ayoub WS, Lagishetty V, Elashoff D, Goodman MT, Jacobs JP. Dietary Protein, Fiber and Coffee Are Associated with Small Intestine Microbiome Composition and Diversity in Patients with Liver CirrhosisNutrients. 2020 May 13;12(5):1395. [PMID: 32414035]


Jones JD, Rahmani E, Garcia E, Jacobs JP. Gastrointestinal Symptoms Are Predictive of Trajectories of Cognitive Functioning in De Novo Parkinson's DiseaseParkinsonism Relat Disord. 2020; 72:7-12. [PMID: 32058266]


Dong TS, Katzka W, Lagishetty V, Luu K, Hauer M, Pisegna J, Jacobs JP. A Microbial Signature Identifies Advanced Fibrosis in Patients with Chronic Liver Disease Mainly Due to NAFLDSci Rep. 2020 Feb 17;10(1):2771. [PMID: 32066758]


Basak SK, Bera A, Yoon AJ, Morselli M, Jeong C, Tosevska A, Dong TS, Eklund M, Russ E, Nasser H, Lagishetty V, Guo R, Sajed D, Mudgal S, Mehta P, Avila L, Srivastava M, Faull K, Jacobs J, Pellegrini M, Shin DS, Srivatsan ES, Wang MB. A randomized, phase 1, placebo-controlled trial of APG-157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor-associated microbesCancer. 2020 Feb 5. doi: 10.1002/cncr.32644. [PMID: 32022261]


Dong TS, Chang HH, Hauer M, Lagishetty V, Katzka, Rozengurt E, Jacobs JP, Eibl G. Metformin Alters the Duodenal Microbiome and Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced ObesityAm J Physiol Gastrointest Liver Physiol. 2019 Dec 1:317(6):G763-G772.


Bajaj JS, Sharma A, Dudeja PK, Iqbal Z, Singh AB, Wilson KT, Taché Y, Pisegna J, Greenwood-Van Meerveld B, Sartor RB, Hecht G, Zhou H, Hylemon P, Im HJ, Jacobs J, Skupsky J, Sun J, Benhammou J, Ince MN, Coburn LA, Brenner L, Safdar N, Gillevet PM. Targeting Gut Microbiome Interactions in Service-Related Gastrointestinal and Liver Diseases of VeteransGastroenterology. 2019 Nov;157(5):1180-1183.e1. [PMID: 31404532]


Hakimian JK, Dong TS, Barahona JA, Lagishetty V, Tiwari S, Azani D, Barrera M, Lee S, Severino AL, Mittal N, Cahill CM, Jacobs JP, Walwyn WM. Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Opioid-Seeking Behaviors and Alters the Gut MicrobiomeNutrients. 2019 Aug 14;11(8). pii: E1900. [PMID: 31416242]


Dong TS, Jacobs JP, Hussain SK. Microbial Profiles of Cirrhosis in the Human Small IntestineCurr Gastroenterol Rep. 2019 Aug 23;21(10):50.PMID: 31444636]


Jacobs JP, Mayer EA. Psychobiotics: Shaping the Mind With Gut BacteriaAm J Gastroenterol. 2019 Jul; 114(7):1034-1035. [PMID: 31268916]


Dong TS, Jacobs JP. Nonalcoholic fatty liver disease and the gut microbiome: Are bacteria responsible for fatty liver? Exp Biol Med (Maywood). 2019 Apr; 244(6):408-418. [PMID: 30871368]


Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ. Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in MiceImmunity. 2019 Jan 15;50(1):212-224.e4 [PMID: 30650377]


Osadchiy V, Labus JS, Gupta A, Jacobs J, Ashe-McNalley C, Hsiao EY, Mayer EA. Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjectsPLoS One. 2018 Aug 6;13(8):e0201772. [PMID: 30080865]


*Jacob N, *Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ. Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiomeMucosal Immunol. 2018 Jul 9. doi: 10.1038/s41385-018-0055-y. [PMID: 29988118] *Co-first authors


Jacobs JP, Dong TS, Agopian V, Lagishetty V, Sundaram V, Noureddin M, Ayoub WS, Durazo F, Benhammou J, Enayati P, Elashoff D, Goodman MT, Pisegna J, Hussain S. Microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis: The Microbiome, Microbial Markers and Liver Disease StudyHepatol Res. 2018 Dec;48(13):1108-1117. doi: 10.1111/hepr.13207. Epub 2018 Jul 30.


Wang J, Ghali S, Xu C, Mussatto CC, Ortiz C, Lee EC, Tran DH, Jacobs JP, Lagishetty V, Faull KF, Moller T, Rossetti M, Chen X, Koon HW. Ceragenin CSA13 Reduces Clostridium difficile Infection in Mice by Modulating the Intestinal Microbiome and MetabolitesGastroenterology. 2018 Jan 19. pii: S0016-5085(18)30067-2. [PMID: 29360463]


Minalyan A, Gabrielyan L, Scott D, Jacobs J, Pisegna JR. The Gastric and Intestinal Microbiome: Role of Proton Pump InhibitorsCurr Gastroenterol Rep. 2017 Aug; 19(8):42. [PMID: 28733944]


Xu C, Ghali S, Wang J, Shih DQ, Ortiz C, Mussatto CC, Lee EC, Tran DH, Jacobs JP, Lagishetty V, Fleshner P, Robbins L, Vu M, Hing TC, McGovern DPB, Koon HW. CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathwayScientific Reports. 2017;7(1):16351. [PMID: 29180648]


*Wang L, *Jacobs JP, Lagishetty V, Yuan PQ, Wu SV, Million M, Reeve JR Jr, Pisegna JR, Taché Y. High-protein diet improves sensitivity to cholecystokinin and shifts the cecal microbiome without altering brain inflammation in diet-induced obesity in ratsAmerican Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2017; 313(4):R473-R486. [PMID: 28724546] *Co-first authors


Volkmann ER, Hoffmann-Vold AM, Chang YL, Jacobs JP, Tillisch K, Mayer EA, Clements PJ, Hov JR, Kummen M, Midtvedt Ø, Lagishetty V, Chang L, Labus JS, Molberg Ø, Braun J. Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohortsBMJ Open Gastroenterology. 2017; 4(1):e000134. [PMID: 28761687]


Li R, Yang J, Saffari A, Jacobs J, Baek KI, Hough G, Larauche MH, Ma J, Jen N, Moussaoui N, Zhou B, Kang H, Reddy S, Henning SM, Campen MJ, Pisegna J, Li Z, Fogelman AM, Sioutas C, Navab M, Hsiai TK. Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid MetabolitesScientific Reports. 2017; 7:42906. [PMID:28211537]


Labus JS, Hollister EB, Jacobs J, Kirbach K, Oezguen N, Gupta A, Acosta J, Luna RA, Aagaard K, Versalovic J, Savidge T, Hsiao E, Tillisch K, Mayer EA. Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome. Microbiome. 2017; 5(1):49. [PMCID:PMC5410709]


Sanmiguel CP, Jacobs J, Gupta A, Ju T, Stains J, Coveleskie K, Lagishetty V, Balioukova A, Chen Y, Dutson E, Mayer E, Labus JS. Surgically induced changes in gut microbiome and hedonic eating as related to weight loss: Preliminary findings in obese women undergoing bariatric surgery. Psychosom Med. 2017 May 30. [Epub ahead of print]


Jacobs JP, Goudarzi M, Singh N, Tong M, McHardy IH, Ruegger P, Asadourian M, Moon B, Ayson A, Borneman J, McGovern DPB, Fornace AJ, Braun J, Dubinsky M. A disease-associated microbial and metabolomics state in relatives of pediatric inflammatory bowel disease patientsCellular and Molecular Gastroenterology and Hepatology. 2016 Jul; 2(6):750-66. [PMID: 28174747]


Jacobs JP, Lin L, Goudarzi M, Ruegger P, McGovern DPB, Fornace AJ, Borneman J, Xia L, Braun J. Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency. Gut Microbes. 2017 Jan; 8(1):1-16. [PMID: 27874308]


*Moussaoui N, *Jacobs JP, Larauche M, Biraud M, Million M, Mayer E, Taché Y. Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex. Journal of Neurogastroenterology and Motility. 2017; 23(1):135-143. [PMCID:PMC5216644] *Co-first authors


Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan SR, Törkvist L, Sharma Y, Devlin B, Borneman J, Hakonarson H, Xavier RJ, Daly M, Brant SR, Rioux JD, Silverberg MS, Cho JH, Braun J, McGovern DP, Duerr RH. A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition. Gastroenterology. 2016; 151(4):724-32. [PMID: 27492617]


Goudarzi M, Mak TD, Jacobs JP, Moon BH, Strawn SJ, Braun J, Brenner DJ, Fornace AJ Jr, Li HH. An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis. Radiation Research. 2016; 186(3):219-34. [PMID: 27512828]


Volkmann ER, Chang YL, Barroso N, Furst DE, Clements PJ, Gorn AH, Roth BE, Conklin JL, Getzug T, Borneman J, McGovern DP, Tong M, Jacobs JP, Braun J. Association of Systemic Sclerosis With a Unique Colonic Microbial Consortium. Arthritis & Rheumatology. 2016; 68(6):1483-92. [PMID: 26749064]


Jacobs J, Braun J. Host genes and their effect on the intestinal microbiome gardenGenome Med. 2014 Dec 17; 6(12):119. [PMID: 25593597]


Tong M, Jacobs JP, McHardy IH. Sampling of intestinal microbiota and targeted amplification of bacterial 16S rRNA genes for microbial ecologic analysis. Curr Protoc Immunol. 2014 Nov 3;107:7.41.1-7.41.11. [PMID: 25367129]


Jacobs JP, Braun J. Immune and genetic gardening of the intestinal microbiomeFEBS Letters. 2014 Nov; 588(22):4102-11. [PMID: 24613921]


McHardy I, Li X, Tong M, Ruegger P, Jacobs J, Borneman J, Anton P, Braun J. HIV infection is associated with compositional and functional shifts in the rectal mucosal microbiotaMicrobiome. 2013 Oct; 1(1):26. [PMID: 24451087]