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UCLA Vatche & Tamar Manoukian Division of Digestive Diseases

UCLA Vatche & Tamar Manoukian Division of Digestive Diseases

UCLA Vatche & Tamar Manoukian Division of Digestive Diseases
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Clinical Trials and Studies

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  • Effectiveness of cognitive behavioral therapy (CBT) for food cravings
  • The brain-gut microbiome of stress-related IBD symptom flares in ulcerative colitis patients
  • Corrona inflammatory bowel disease registry
  • IBD influences the diet and the diet influences IBD
  • Nutrition counseling for irritable bowel syndrome (IBS)
  • Stress management in irritable bowel syndrome (IBS)

Effectiveness of Cognitive Behavioral Therapy (CBT) for Food Cravings

Dr. Arpana Gupta, G. Oppeneheimer Center for Neurobiology of Stress and Resilience (CNSR), is conducting a study to test the effectiveness of a focused cognitive behavioral therapy (CBT) for food cravings.

Participants must be:

  • 18-50
  • Overweight or obese

Participation consists of :

  • 5 visits over a period of 8 months
  • Two MRIs of the brain
  • 3 blood draws and 4 stool samples
  • Monthly online questionnaires
  • Wearing a smartwatch to monitor food cravings

Compensation:

  • Earn up to $590
  • Free picture of your brain
  • Free parking

To learn more about participating in this study, please contact Jean Stains, RN, at 310-206-1758

Protocol ID: IRB# 16-000281 - UCLA IRB Approved - Committee: Medical IRB 3 - Approval Date 12/6/2019 Expiration Date 8/7/2020


Dietary Patterns in Patients with Inflammatory Bowel Diseases Research - IBD Influences the Diet and the Diet Influences IBD

Dr. Berkeley Limketkai, directof of clinical research for the Center for Inflammatory Bowel Diseases, is conducting a research study to better understand the relationship between the diet and IBD and to help guide us on where to focus the next steps of research to provide better dietary recoomendations and improve the care of IBD.

Participants must be:

  • 18 years or older
  • Diagnosed with ulcerative colitis or Crohn's disease

Participation involves:

  • A 20-minute questionnaire during your clinic visit
  • Electronic diet questionnaire to be done in the convenience of your own home
  • Follow-up questionnaire may be requested at your next clinic visits

To learn more about participating in this study, please contact Miriam Dvorsky at 310-206-3778 or mdvorsky@mednet.ucla.edu

UCLA IRB Approved IRB# 19-001299 Committee: Medical IRB 1 Approved / Expiration Date 9/4/2020


UC Longitudinal Study: The Brain-Gut Microbiome Signatures of Stress-related Inflammatory Bowel Disease (IBD) Symptom Flares in Ulcerative Colitis (UC) Patients

Help us answer some intriguing questions about the effect of stress on ulcerative colitis symptoms. Dr. Emeran A. Mayer, director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience (CNSR), Dr. Jenny Sauk, clinical director of the Center for Inflammatory Bowel Diseases, and Dr. Jonathan P. Jacobs, director of the Jacobs Laboratory, are conducting the UC Longitudinal Study to identify novel brain-gut-microbiome pathways that cause symptoms in IBD patients. This research study is to improve our understanding of IBD and its underlying cause.

We will use magnetic resonance imaging (MRI) to observe differences in the brain between people diagnosed with UC compared to healthy controls. We will also collect other measures such as thermal sensitivity and blood and stool samples, to be able to make biological connections associated with the subject groups. By doing this study, we hope to enhance our knowledge on IBD in order to keep the field moving in the right direction and becoming one step closer to discovering effective treatments.

Participants must be:

  • Diagnosed with ulcerative colitis
  • Between the ages of 18-65
  • Able to do an MRI (no implanted metals)
  • Not pregnant or breast feeding

Compensation:

  • Participants can earn up to $400 and receive a digital image of your brain

For further details please call Miriam Dvorsky at 310-206-3778 or mdvorsky@mednet.ucla.edu or Hyo Jin Ryu at 310-825-7206.

UCLA IRB Approved IRB# 18-000470 Committee: Medical IRB 3 Approval Date: 4/25/2018 through 3/4/2020


Corrona Inflammatory Bowel Disease (IBD) Registry

The purpose of this registry study is to learn more about IBD, how doctors treat IBD, how well medications and other treatments work, the safety of those treatments, and to improve the care and outcomes of people with IBD. Approximately 1,000 men and women ages 18 years and older with a diagnosis of IBD in the U.S. are expected to participate in the first year with no defined upper limit on total enrollment after year one. Non-interventional Corrona Registry research programs are coordinated efforts to collect information directly from physicians and patients with IBD. Findings from Corrona Registries will help providers improve the treatment options for these health conditions.

Participants must be:

  • 18 years or older
  • Diagnosed with one of the following: Crohn’s disease, ulcerative colitis or indeterminate colitis

Compensation:

  • Participants will be compensated $25.00 in the form of an American Express gift card for each registry visit they complete

This study is conducted by Dr. Jenny Sauk with the Center for Inflammatory Bowel Diseases. For further details please call Miriam Dvorsky at 310-206-3778 or mdvorsky@mednet.ucla.edu

UCLA IRB Approved IRB# 17-001324 Approval Date: 5/23/2019 through 5/22/2020


Nutrition Counseling for Irritable Bowel Syndrome (IBS)

Do you suffer from abdominal pain, constipation, and/or diarrhea? Have you ever been told you have irritable bowel syndrome (IBS)? If so, and you are 18 years or older, you may qualify to participate in a UCLA research study that involves free nutrition sessions with a skilled IBS-specializing dietitian.

If so, we invite you to participate in brain imaging research at the G. Oppenheimer Center for Neurobiology of Stress and Resilience. 

To participate, you must be:

  1. 18 years of age
  2. Have never met with Nancee Jaffe, MS, RDN or Janelle Smith, MS, RDN or tried the low-FODMAP diet before
  3. For any medications currently taking - dosing has not changed in past 30 days
  4. Have no history of prior digestive surgery excluding appendectomy, or prior organic digestive illness diagnosed by your doctor
  5. Have not taken antibiotics in the past 2 months
  6. Do not have a current diagnosed eating disorder within the past 6 months
  7. Have not had a cholecystectomy within the last 6 months

This study is conducted by Lin Chang, MD, G. Oppenheimer Center for Neurobiology of Stress and Resilience.

If interested, please contact Eileen Liu at 310-506-1656 or eileenliu@mednet.ucla.edu

Protocol ID: IRB #10-000934 UCLA IRB Approval Date: 7/31/2019 through 7/9/2020 Committee: Medical IRB 1


Stress Management in Irritable Bowel Syndrome

Do you suffer from abdominal pain, constipation and/or diarrhea? Have you ever been told that you have irritable bowel syndrome or IBS? If so, you may qualify to participate in a research study involving a treatment program designed to target stress in patients with irritable bowel syndrome (IBS).

To participate, you must be:

  1. At least 18 years of age
  2. Interested in a program that involves group sessions and an online course to help manage stress
  3. If you are currently taking medications, the doses have not changed in 30 days
  4. Have NO history of other digestive or gastrointestinal illnesses diagnosed by your doctor
  5. Have NO history of digestive or gastrointestinal surgery excluding appendectomy and gallbladder removal
  6. Are NOT currently receiving (or have received in the last 6 months) other psychological or stress reduction therapies (for example: cognitive behavioral therapy (CBT), mindfulness, meditation, psychotherapy)
  7. Do NOT have severe anxiety, depression or schizophrenia
  8. Do NOT have current substance (drugs and/or alcohol) abuse problems
  9. Are NOT pregnant

Eligible participants will:

  1. Participate in either a stress management program that involves 90 minute group introductory session at UCLA and participation in group teleconferences or start a selfmanagement stress reduction program that requires reading a book over 12 weeks.
  2. Complete a 12 week online program that requires 10 minutes of your time weekly.
  3. You will be asked to complete online surveys up to 3 or 4 times.

Compensation:

  • Participants can earn up to $125-$175 for participation and completion of questionnaires.

This study is conducted by Lin Chang, MD, G. Oppenheimer Center for Neurobiology of Stress and Resilience. If interested, please contact Eileen Liu at 310-506-1656 or eileenliu@mednet.ucla.edu

*Please note that confidentiality of emails cannot be guaranteed. Do not include sensitive information in your email if you choose to contact us by that method.

Protocol ID:IRB#18-000235 UCLA IRB Approved Approval Date: 1/14/2019 Through: 1/13/2022 Committee: Medical IRB 1


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