Our mission is to study important ear diseases at the cell and molecular level. A primary focus of research of this laboratory is the pathogenesis of otitis media, including bacteria-host cell interactions, cell signaling, host-innate immune responses, mechanisms of the inner ear inflammatory response to otitis media pathogens, and the development of an innovative strategy to treat or prevent otitis media using antimicrobial innate immune molecules. Another area of research focuses on the elucidation of the molecular and cellular mechanisms involved in inner ear homeostasis, particularly in regard to the structure/functions of the endolymphatic sac, and the pathogenesis of Meniere's disease and endolymphatic hydrops.
David J. Lim, MD
(213) 353-7021 (office)