Clinical Trials and Studies

AnX NaviCam capsule endoscopy study for gastroparesis and functional dyspepsia

Lin Chang, MD, co-director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience, is conducting a magnetically controlled capsule endoscopy system on gastroparesis and functional dyspepsia patients.

You may be eligible if you:

• Between the ages of 18 to 60 years
• Diagnosed with either functional dyspepsia or gastroparesis
• Not pregnant or nursing
• No significant neurological, psychological or other health history

Study participation consists of:

• One screening visit
• Capsule endoscopy procedure
• Online questionnaires

Compensation:

• Earn up to $150
• Free parking provided

For more information: Call 310-206-1656

Protocol ID:IRB#20-001573 UCLA IRB Approved End Date: 06/2023 Committee: Medical IRB 1

3-D imaging in colonic mucosa of female IBS-C individuals on Linzess/Linaclotide

Lin Chang, MD, co-director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience, is conducting a study to test a new CLARITY imaging technique to map the colonic mucosa in female IBS-C patients on the medication Linzess and those not on the medication.

You may be eligible if you:

• Between the ages of 18 to 50 years
• Are currently taking the medication Linzess
• Not pregnant or nursing
• No significant neurological, psychological or other health history

Study participation consists of:

• One screening visit
• One sigmoidoscopy procedure
• Online questionnaires

Compensation:

• Earn up to $150
• Free parking provided

For more information: Call 310-206-1656

Protocol ID:IRB#20-001727 UCLA IRB Approved End Date: 06/2023 Committee: Medical IRB 1

3-D imaging in colonic mucosa of IBS-D, IBS-C and healthy controls

Lin Chang, MD, co-director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience, is conducting a study to test a new CLARITY imaging technique to map the colonic mucosa in IBS patients.

You may be eligible if you:

• Between the ages of 18 to 50 years
• Not pregnant or nursing
• No significant neurological, psychological or other health history

Study participation consists of:

• One screening visit
• One sigmoidoscopy procedure
• Online questionnaires

Compensation:

• Earn up to $150
• Free parking provided

For more information: Call 310-206-1656

Protocol ID:IRB#20-000241 UCLA IRB Approved End Date: 02/2023 Committee: Medical IRB 1

Research on effects of social isolation and discrimination

Arpana Gupta, PhD, G. Oppenheimer Center for Neurobiology of Stress and Resilience, is conducting a study on the effects of stress and discrimination in Mexican and Filipina women.

You may be eligible if you:

• Premenopausal female of Mexican or Filipina ancestry*
• Between the ages of 18 to 50 years
• Right-handed
• Not pregnant or nursing
• No significant neurological, psychological or other health history

MUST be of 100 percent Mexican or 100 percent Filipina ancestry

Study participation consists of:

• Two (2) visits (screening brain MRI)
• Two (2) stool samples
• One (1) blood sample
• Online questionnaires about diet and mood
• Optional follow-up visits at three (3) and six (6) months

Compensation:

• Earn up to $285
• Free parking provided

For more information: Call 310-825-7206

Protocol ID:IRB#20-002326 UCLA IRB Approved End Date: 12/2025 Committee: Medical IRB 3

Study on women and stress

Arpana Gupta, PhD, G. Oppenheimer Center for Neurobiology of Stress and Resilience, is conducting a study comparing women with high and women with low stress.

You may be eligible if you:

• Caucasian female
• Between the ages of 18 to 45 years
• Not pregnant or nursing
• Consider yourself to be either a high stress type person or a low stress type of person

Study participation consists of:

• One (1) phone/Zoom screening
• One (1) 2-hour laboratory stress test day consisting of 4 short cognitive stress tests
• Two (2) finger pricks for blood sample and one (1) small stool sample collected at home
• Online questionnaires

Compensation:

• Earn up to $225
• Free parking provided
• Sponsored by Danone Research

For more information: Call Allison at 310-825-7206

Protocol ID:IRB#20-001921 UCLA IRB Approved End Date: 12/2022 Committee: Medical IRB 3

Cognitive behavioral therapy (CBT) for gastrointestinal pain

Emeran A. Mayer, MD, director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience, is conducting a study to test the effect of cognitive behavioral therapy (CBT) on the brain and gut in irritable bowel syndrome (IBS).

You may be eligible if you:

• Have chronic abdominal pain with altered bowel habits for at least 6 months OR diagnosed with IBS
• Between the ages of 18 to 55 years
• If female, not pregnant, post-partum or breast feeding
• Have no significant medical or psychological history
• Not currently practicing CBT or have completed CBT treatment in the last 2 years

Some details:

• Participation involves a screening, online questionnaires, a before and after CBT brain MRI visit with a blood and stool sample and 8 weeks of internet guided CBT

Compensation:

• Men may earn up to $430
• Women may earn up to $480
• Everyone will receive a digital image of their brain

For more information: Email [email protected] or call 310-206-1719

Sex related differences in the effect of cognitive behavioral therapy (CBT) on  emotional arousal and salience circuits and the role of the gut microbiome Project 3 Protocol ID:IRB#20-001118 UCLA IRB Approved Approval Date: 1/22/2021 Committee: Medical IRB 3

Clinical trial of novel diet for Crohn's disease

Berkeley Limketkai, MD, PhD, director of clinical research for the Center for Inflammatory Bowel Diseases, in partnership with the Center for Human Nutrition, is conducting a trial of a UCLA-designed diet for Crohn’s disease.

You may be eligible if you:

• Have Crohn’s disease with mild to moderate symptoms
• Between the ages of 18 to 75 years

Some details:

• Participation will last 9 weeks with 4 clinic visits and 2 video visits
• The first visit is a screening visit to ensure eligibility
• Visits include blood tests, stool tests, dietary surveys and dietary counseling
• You will be randomized into one of two different diets

Compensation:

• You will be paid up to $150 for your participation

For more information: 855-IBD-UCLA / 855-423-8252 or [email protected]

Study of dietary composition in Crohn's disease, IRB#20-001120 UCLA IRB Approval Date: Through 4/7/22, Committee: Medical IRB 3, PI: Li

Looking for a non-drug alternative to reduce your IBS-related pain?

IB-Stim is a non-invasive device that works by sending subtle electrical impulses into cranial nerve branches in the ear. This stimulation then targets brain regions involved in processing pain. The IB-Stim has already been FDA approved for treating functional abdominal pain associated with IBS in children but not FDA approved in adults.

Participants must be:

• 18-60 years of age
• Diagnosed with IBS
• Not pregnant or breastfeeding
• Have no significant neurological or psychological medical history

Participation consists of :

• 4 visits over 1 month plus follow-up online questionnaires
• Each visit: New IB-STIM device placement
• Device work 5 days a week for 4 weeks

Compensation:

• Earn up to $175 for completing all visits
• Free parking

To learn more about participating in this study, please contact Dr. Adrienne Lenhart at [email protected]

This study is conducted by Lin Chang, MD, co-director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience.

Protocol ID: IRB#19-001796 UCLA IRB Approval Date: 7/8/2021 Through: 5/11/2023 Committee: Medical IRB

Dietary patterns in patients with inflammatory bowel diseases research

Dr. Berkeley Limketkai, director of clinical research for the Center for Inflammatory Bowel Diseases, is conducting a research study to better understand the relationship between the diet and IBD and to help guide us on where to focus the next steps of research to provide better dietary recommendations and improve the care of IBD.

Participants must be:

• 18 years or older
• Diagnosed with ulcerative colitis or Crohn's disease

Participation involves:

• A 20-minute questionnaire during your clinic visit
• Electronic diet questionnaire to be done in the convenience of your own home
• Follow-up questionnaire may be requested at your next clinic visits

For more information: 855-IBD-UCLA / 855-423-8252 or [email protected]

UCLA IRB Approved IRB# 19-001299 Committee: Medical IRB 1 Approved / Expiration Date 3/17/22

CorEvitas inflammatory bowel disease (IBD) registry

The purpose of this registry study is to learn more about IBD, how doctors treat IBD, how well medications and other treatments work, the safety of those treatments, and to improve the care and outcomes of people with IBD. Approximately 1,000 men and women ages 18 years and older with a diagnosis of IBD in the U.S. are expected to participate in the first year with no defined upper limit on total enrollment after year one. Non-interventional Corrona Registry research programs are coordinated efforts to collect information directly from physicians and patients with IBD. Findings from CorEvitas Registries will help providers improve the treatment options for these health conditions.

Participants must be:

• 18 years or older
• Diagnosed with one of the following: Crohn’s disease, ulcerative colitis or indeterminate colitis

Compensation:

• Participants will be compensated $25.00 in the form of an American Express gift card for each registry visit they complete

This study is conducted by Dr. Jenny Sauk with the Center for Inflammatory Bowel Diseases. For further details please contact Xiaoxiao Yin at [email protected].

UCLA IRB Approved IRB# 17-001324 Approval Date: 3/30/2020 through 1/10/2023.