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Joseph G. Crompton, MD, PhD

Surgical Oncology
Primary Location
Thoracic Surgery
200 Medical Plaza
Los Angeles, California 90095


Dr. Joseph G. Crompton is a surgeon-scientist with a primary clinical focus on the multi-modality treatment of melanoma and soft tissue sarcoma. His current research interests include characterizing the immune response to cancer and developing novel immunotherapies to treat advanced disease.


Medical Board Certification

Surgery, American Board of Surgery, 2019


Memorial Sloan-Kettering Cancer Center, 2020
National Cancer Institute, 2015


UCLA School of Medicine, 2018


Magdalene College University of Cambridge, PhD, 2016
Johns Hopkins University School of Medicine, MD, 2009


Hospital Affiliations

Ronald Reagan UCLA Medical Center



  1. Crompton JG, Narayanan M, Cuddapah S, Roychoudhuri R, Ji Y, Yang W, Patel SJ, Sukumar M, Palmer DC, Peng W, Wang E, Marincola FM, Klebanoff CA, Zhao K, Tsang JS, Gattinoni L, Restifo NP. Lineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape. Cell Mol Immunol. 2015.
  2. Crompton JG, Sukumar M, Roychoudhuri R, Clever D, Gros A, Eil RL, Tran E, Hanada K, Yu Z, Palmer DC, Kerkar SP, Michalek RD, Upham T, Leonardi A, Acquavella N, Wang E, Marincola FM, Gattinoni L, Muranski P, Sundrud MS, Klebanoff CA, Rosenberg SA, Fearon DT, Restifo NP. Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics. Cancer Research 2015.
  3. Klebanoff CA, Crompton JG, Leonardi AJ, Yamamoto TN, Chandran SS, Eil RL, Sukumar M, Vodnala SK, Hu J, Ji Y, Clever D, Black MA, Gurusamy D, Kruhlak MJ, Jin P, Stroncek DF, Gattinoni L, Feldman SA, Restifo NP. Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy. JCI Insight. 2017.


  • Wilma Miley Morton Award for Excellence in Research, David Geffen School of Medicine, 2018
  • Excellence in Teaching with Humanism Residents Award, David Geffen School of Medicine, 2017
  • Scientific Day Resident Award, UCLA Department of Surgery, Longmire Surgical Society, 2016
  • American College of Surgeons Leadership and Advocacy Summit Resident Award, 2016
  • Clinical Cancer Research Federal Technology Transfer Award, National Cancer Institute, 2014
  • Wellcome Trust Translational Medicine and Therapeutics Research Fellowship, 2012