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  4. Tabibian Laboratory

Tabibian Laboratory

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James Tabibian, MD, PhD

The Tabibian Laboratory takes a collaborative and multi-pronged approach to research centered around the following overarching and interwoven areas of focus:

  1. Novel techniques, applications, and advances in gastrointestinal and biliary endoscopy
  2. Disparities and ethnoracial variations in digestive diseases
  3. Pathogenesis, diagnosis, treatment, and surveillance of cholangiopathies (e.g. primary sclerosing cholangitis)
  4. Training the next generation of well-rounded, academic gastroenterologists and advanced endoscopists
  5. Quality imporvement, medical professional liability, and risk mitigation in gastroenterology

Key investigator

  • James H. Tabibian, MD, PhD, FACP

Extramural collaborators

  • Christopher L. Bowlus, MD, FAASLD – UC Davis
  • Elizabeth J. Carey, MD, FAASLD - Mayo Clinic Arizona
  • Vinay Chandrasekhara, MD – Mayo Clinic Rochester
  • Mohit Girotra, MD, FACP – University of Miami Miller School of Medicine
  • Christopher J. Gostout, MD, FASGE - Mayo Clinic Rochester (Emeritus)
  • Nicholas F. LaRusso, MD, FAASLD, AGAF – Mayo Clinic Rochester
  • Keith D. Lindor, MD, FAASLD – Mayo Clinic Arizona and Arizona State University
  • Valentina Medici, MD - UC Davis
  • Steven P. O'Hara, PhD - Mayo Clinic Rochester
  • Júlio Pereira Lima, MD - Universidade Federal de Ciências da Saúde de Porto Alegre, Brasil
  • Sooraj Tejaswi, MD, MSPH - UC Davis
  • Sachin Wani, MD – University of Colorado

Current research projects

  • Disparities in gastroenterology: A nationwide survey - Principal Investigator: James H. Tabibian, MD, PhD
  • Clinical epidemiology of acute pancreatitis in Los Angeles County Department of Health Services - Principal Investigator: James H. Tabibian, MD, PhD
  • External validation of the EVendo score for prediction of presence and size of esophageal varices - Principal Investigator: James H. Tabibian, MD, PhD
  • Endoscopy in chronic and advanced liver disease - Principal Investigator: James H. Tabibian, MD, PhD
  • Predictors of false positive FIT in a safety-net population - Principal Investigator: James H. Tabibian, MD, PhD
  • Development and validation of a machine learning-based score to predict presence of choledocholithiasis - Principal Investigator: James H. Tabibian, MD, PhD
  • Clinical epidemiology of inflammatory bowel disease: a Los Angeles County population-based study - Principal Investigator: James H. Tabibian, MD, PhD
  • The evolving clinical profile and outcomes of patients with choledocholithiasis - Principal Investigator: James H. Tabibian, MD, PhD

Recently completed research projects

  • Epidemiology of signet ring cell carcinoma of the stomach: clinical features and outcomes - Principal Investigator: James H. Tabibian, MD, PhD
  • The enterohepatic metabolome in primary sclerosing cholangitis - Principal Investigator: James H. Tabibian, MD, PhD
  • Risk stratification for esophageal variceal screening in cirrhosis - Principal Investigator: James H. Tabibian, MD, PhD
  • Cancer risk in primary sclerosing cholangitis - Principal Investigator: James H. Tabibian, MD, PhD
  • Biliary endoscopy in the management of primary sclerosing cholangitis and its complications - Principal Investigator: James H. Tabibian, MD, PhD

Future research directions

Listed below are some of the planned upcoming research projects and manuscripts (original and review) in the Tabibian Laboratory. Trainee-initiated proposals are welcomed.

  • Head-to-head, randomized clinical trial of rectal indomethacin vs. intravenous ketorolac for the prevention of post-ERCP pancreatitis
  • Development and validation of a score for risk stratification and triage of patients with acute GI bleeding
  • Yield of post-acute diverticulitis colonoscopy to rule out colon cancer: an analysis of the LADHS population

Current GI fellows

  • Saroja Bangaru, MD – UCLA

Current residents

  • John Azizian, MD - UCLA-Olive View Internal Medicine Residency Program
  • Cami Dalai, MD - UCLA-Olive View Internal Medicine Residency Program
  • Jade Law, MD - UCLA-Olive View Internal Medicine Residency Program
  • Harman Rahal, MD - UCLA Internal Medicine Residency Program
  • Anand Rajan, MD - UCLA Internal Medicine Residency Program
  • Simcha Weissman, MD - Hackensack University Medical Center Internal Medicine Residency Program

In the news

  • EVendo Score Webpage Goes Live (2019)
    The EVendo Score — developed to noninvasively, quickly and reliably predict the presence and size of esophageal varices for risk stratification purposes in patients with cirrhosis — is now live online and available in MDCalc. It was developed and validated by James H. Tabibian, MD, PhD, director of endoscopy at Olive View-UCLA Medical Center, and recent UCLA fellowship graduates Tien Dong, MD, and Amir Kalani, MD, PhD, along with other colleagues. The full original article, “Machine Learning-based Development and Validation of a Scoring System for Screening High-Risk Esophageal Varices,” was published in the August 2019 issue of Clinical Gastroenterology and Hepatology.

Past GI fellows

  • Tien S. Dong, MD, PhD – UCLA
  • Armen Eskandari, MD - UC Davis
  • Phillip Fejlah, MD - UCLA
  • Moira Hilscher, MD – Mayo Clinic Rochester
  • Mohamad H. Imam, MD – University of Tennessee Health Science Center
  • Amir Kalani, MD, PhD - UCLA
  • Ryan Perumpail, MD - UCLA
  • Kais Zakharia, MD - Beaumont Health Systems

Past residents

Shown here are residents and post-graduate trainees whom were mentored by Dr. Tabibian and have at least one 1st-author national presentation and/or peer-reviewed manuscript:

  • Nabeel Azeem, MD – Mayo Clinic Rochester (went on to GI fellowship at UCSF)
  • Rani Berry, MD – UCLA Internal Medicine Residency Program (went on to GI fellowship at Stanford)
  • Brian Fung, MD – UCLA-Olive View Internal Medicine Residency Program (went on to GI fellowship at University of Arizona)
  • James Han, MD - Department of Medicine Residency Program, UC Irvine (went on to GI fellowship at UCI)
  • Gururaj Kolar, MD - Mayo Clinic Research Trainee (went on to IM residency in Massachusetts and faculty at Mayo Clinic Mankato)
  • Long Le, MD – UCLA-Olive View Internal Medicine Residency Program (went on to become chief resident, applying for GI fellowship)
  • Amanda Lynn, MD – Mayo Clinic Rochester (went on to GI fellowship at Mayo Clinic Rochester)
  • Mital Patel, MD – UCLA-Olive View Internal Medicine Residency Program (went on to hem/onc fellowship)
  • Neha Patel, MD – UCLA-Olive View Internal Medicine Residency Program (went on the nephrology fellowship)
  • Kevin P. Quinn, MD – Mayo Clinic Rochester (went on to GI fellowship at Mayo Clinic Rochester)
  • Cyril Varghese, MD – Mayo Clinic Rochester (went on to pulmonary/critical care fellowship at Mayo Clinic Rochester)
  • Kavel Visrodia, MD – Mayo Clinic Rochester (went on to GI fellowship at Mayo Clinic Rochester)
  • Ale Zhornitskiy, MD - UCLA-Olive View Internal Medicine Residency Program (went on to UCLA hospitalist, applying for GI fellowship)

Selected publications

  1. Fejleh MP, Tabibian JH. Colonoscopic Management of Diverticular Disease. World J Gastrointest Endosc. 2020 Feb 16;12(2):5359. doi: 10.4253/wjge.v12.i2.53
  2. Fung BM, Tabibian JH. Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis. Curr Opin Gastroenterol. 2020 Mar;36(2):77-84. doi: 10.1097/MOG.0000000000000616
  3. Kalani A, Phan J, Taefi A, Deshmukh M, Yamamoto A, Tabibian. Necrotizing Pancreatitis: Common and Uncommon Sequelae and Solutions. Dig Dis Sci. 2019 Oct;64(10):3020-3023. doi: 10.1007/s10620-019-05634-2. Epub 2019 Apr 27
  4. Weissman S, Lo A, Patel R, Mehta TI, Singh V, Aziz M, Belyayeva A, Cherian J, Amrutiya V, Atoot A, Hassan A, Sotiriadis J, Atoot A, Tabibian JH. An Unusual Culprit of Drug-Induced Pancreatitis. Dig Dis Sci. 2019 Sep 30. doi: 10.1007/s10620-019-05864-4 [Epub ahead of print]
  5. Aby ES, Benhammou JN, Tabibian JH. My Doctor Told Me I Have Fatty Liver - What Do I Need to Know? JAMA Intern Med 2019 Jul 1. doi: 10.1001/jamainternmed.2019.1240
  6. Berry R, Han JY, Tabibian JH. Difficult Biliary Cannulation: Historical Perspective, Practical Updates, and Guide for the Endoscopist. World J Gastrintest Endosc. 2019 Jan 16;11(1):5-21. doi: 10.4253/wjge.v11.i1.5
  7. Le L, Fung BM, Tabibian JH. Capsule Endoscopy for Refractory Iron Deficiency Anemia in Crohn's Disease: Captivating Pathology, Hybrid Therapy. Gastroenterology. 2018 Jan 31. doi: 10.1053/j.gastro.2018.01.055
  8. Fung BM, Kalani A, Tabibian JH. Variceal Hemorrhage With White Nipple Sign Associated With Strangulated Umbilical Hernia in a Patient With Cirrhosis. Clin Gastroenterol Hepatol. 2018 Feb 6. doi: 10.1016/j.cgh.2018.01.050
  9. Zakharia K, Tabibian A, Lindor KD, Tabibian JH. Complications, Symptoms, Quality of Life, and Pregnancy in Cholestatic Liver Disease. Liver Int. 2017 Sep 18. doi: 10.1111/liv.13591
  10. Ali AH, Tabibian JH, Naser-Ghodsi N, Lennon RJ, DeLeon T, Borad MJ, Hilscher M, Silveira MG, Carey EJ, Lindor KD. Surveillance for Hepatobiliary Cancers in Patients with Primary Sclerosing Cholangitis. Hepatology. 2017 Dec 15. doi: 10.1002/hep.29730
  11. Hilscher M, Enders FB, Carey EJ, Lindor KD, Tabibian JH. Normalization of Serum Alkaline Phosphatase is a Biomarker of Improved Survival in Primary Sclerosing Cholangitis. Ann Hepatol. 2016 Mar-Apr 2016;15(2):246-253
  12. Tabibian JH, Yang J, Baron TH, Kane SV, Enders FB, Gostout CJ. Weekend Admission for Acute Cholangitis Does Not Adversely Impact Endoscopic or Clinical Outcomes. Dig Dis Sci. 2016 Jan;61(1):53-61
  13. Tabibian JH, O'Hara SP, Trussoni CE, Tietz PS, Splinter PL, Mounajjed T, Hagey LR, Larusso NF. Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis. Hepatology. 2016 Jan;63(1):185-96
  14. Tabibian JH, Visrodia KH, Levy MJ, Gostout CJ. Advanced endoscopic imaging of indeterminate biliary strictures. World J Gastrointest Endosc. 2015 Dec 10;7(18):1268-78
  15. Tabibian JH, Macura SI, O'Hara SP, Fidler JL, Glockner JF, Takahashi N, Lowe VJ, Kemp BJ, Mishra PK, Tietz PS, Splinter PL, Trussoni CE, Larusso NF. Micro-computed tomography and nuclear magnetic resonance imaging for noninvasive, live-mouse cholangiography. Lab Invest. 2013 Jun;93(6):733-43
  16. Tabibian JH, Weeding E, Jorgensen RA, Petz JA, Keach JC, Talwalkar JA, Lindor KD. Randomised clinical trial: vancomycin or metronidazole in patients with primary sclerosing cholangitis - a pilot study. Aliment. Pharmacol. Ther. 2013 Mar;37(6):604-12

View a detailed list of Dr. Tabibian's publications indexed in the National MEDLINE database


Funding support

  • 2018: Mayo Clinic Arizona Small Grants Proposals Fund (1 year, $6,881, NIH impact/priority score 1.7)  - “Cost-consequences simulation model of diagnosing cholangiocarcinoma for patients with PSC”  - Principle Investigator: Elizabeth J. Carey; Co-Investigators: James H. Tabibian et al
  • 2014 - 2015: AASLD Clinical and Translational Research Award (2 years, $150,000) - “Intestinal permeability and enterohepatic metabolome in primary sclerosing cholangitis” - Principle Investigator: James H. Tabibian
  • 2013 - 2014: PSC Partners Seeking a Cure Annual Research Grant (1 year, $30,000) - “Cholangiocyte senescence associated secretory phenotype as a therapeutic target in PSC” - Principle Investigators: James H. Tabibian et al
  • 2011 - 2013: PSC Partners Seeking a Cure Annual Research Grant (2 years, $60,000) - “Potential Role of Cholangiocyte Senescence in PSC” - Principle Investigator: Nicholas F. LaRusso; Co-Investigators: James H. Tabibian et al

Selected editorial, societal and leadership positions

  • 2017 - Present: Abstract Reviewer, The Liver Meeting and Digestive Disease Week (DDW), American Association for the Study of Liver Diseases
  • 2017 - Present: Section Editor, Gastroenterology, Hepatology and Endoscopy section, Journal of Community Medicine
  • 2016 - Present: Scientific and Medical Advisory Board, PSC Partners Seeking a Cure
  • 2017 - 2018: Lead Guest Editor, "Advances in Therapeutic Endoscopy.” Special issue, Gastroenterology Research & Practice
  • 2016: Lead Guest Editor, “Advances in biliary tract disorders: novel biomarkers, pharmacotherapies, endoscopic techniques, and surgical management.” Special issue, Gastroenterology Research & Practice
  • 2015 - 2018: Associate Editor, Annals of Hepatology (Official journal of the MAH, LAASL, and CASL)
  • 2015 - 2017: Board of Directors, PSC Partners Seeking a Cure
  • 2015 - 2016: Membership and Diversity Committee member, ASGE
  • 2013 - 2015: Editorial Board, Annals of Hepatology
  • 2012 - 2016: Editorial Board, Journal of Analytical Oncology
  • 2012 - 2014: Associate Editor, Pancreatobiliary diseases section, BMC Gastroenterology
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