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UCLA Obstetrics and Gynecology

Clinical Trials

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Clinical Trials

Featured Study:

GOG 3059: A Phase 3, Randomized, Double-Blind, Adaptive, Placebo/Paclitaxel-Controlled Study of AVB-S6-500 in combination with Paclitaxel in Patients with Platinum-Resistant Recurrent Ovarian Cancer 

This is a study for women who have advanced recurrent ovarian cancer, specifically high-grade serious ovarian cancer that is platinum resistant. The Principal Investigators of this study is Ritu Salani, MD, Division Director for UCLA Gynecologic Oncology. For more information > 

 

The UCLA OBGYN physicians are nationally and internationally recognized not only for their clinical expertise but also for their pioneering research. Our goal is to increase basic research and translate the findings into clinical trials.

What is a clinical trial? A clinical trial is a study conducted with actual patients, usually to evaluate a new treatment. Each study is designed to answer scientific questions and to find new and better ways to help our patients.

 

Cancer - Ovarian, Fallopian Tube and Peritoneal Cancer

 

Currently Enrolling

  • Recurrent Ovarian Cancer: GOG 3045: IMGN853-0416: MIRASOL: A Randomized, Open-label, Phase 3 Study of Mirvetuximab Soravtansine vs. chemo in Platinum-Resistant, Advanced High-grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers

  • Recurrent Ovarian Cancer: GOG 3059: A Phase 3, Randomized, Double-Blind, Adaptive, Placebo/Paclitaxel-Controlled Study of AVB-S6-500 in combination with Paclitaxel in Patients with Platinum-Resistant Recurrent Ovarian Cancer 

 

Cancer - Uterine and Endometrial

 

Currently Enrolling

  • Testing the Addition of Pembrolizumab to Paclitaxel and Carboplatin for Endometrial Cancer

  • Radiation +/- Pembrolizumab for Newly Diagnosed, High Intermediate Risk Endometrioid Endometrial Cancer

  • Advanced or Metastatic Endometrial Cancer: GOG 3038: A Multicenter, Open-label, Nonrandomized, Phase 2 Umbrella Study of INCMGA00012 Alone and in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-Based Chemotherapy (POD1UM-204)

 

Cancer - Cervical

 

Currently Enrolling

  • A Phase II open-label, single arm pilot study to evaluate the safety and efficacy of pembrolizumab for high-grade cervical intraepithelial neoplasia

  • Advanced Cervical Cancer: A Randomized, Phase 3, Double-Blind Study of Chemoradiotherapy With or Without Pembrolizumab for the Treatment of High-risk, Locally Advanced Cervical Cancer

 

Women at High Risk for Ovarian and Breast Cancers

 

Currently Enrolling

  • A Study to Compare Two Surgical Procedures in Women With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer (NRG-CC008)

 

Benign / Non-Cancer

 

Currently Enrolling

  • Study to Assess Contraceptive Efficacy and Safety of the Etonogestrel (MK-8415) Implant

  • Androgen Excess as a Mechanism for Adipogenic Dysfunction in PCOS Women

  • CELLEBRATE: An Adaptive, Two Stage, Double-Blind, Stratified, Randomized, Controlled Trial Comparing the Safety and efficacy of AMDC-USR with Placebo in Female Subjects with Stress Urinary Incontinence
  • Pudendal Nerve Block Enhancement of Enhanced Recovery After Surgery (ERAS) for Reconstructive Surgery
  • Vestibulodynia: Understanding Pathopysiology and Determining Appropriate Treatments
  • Heparin Prophylaxis Dosing for Antepartum Hospitalizations (HEPDOSE)
  • EASE Study: A Randomized, Controlled Study to Evaluate the Safety and Effectiveness of the Materna Prep Device To Pre Stretch (I.E., Dilate) The Vaginal Canal And Pelvic Floor Muscles In Preparation For Vaginal Delivery


Research Studies

 

Currently Enrolling

  • Research Study for Women With Regular and Irregular Menstrual Cycles

  • Perinatal Mood and Behavioral Tracking Study
  • PRIORITY (Pregnancy CoRonavirus Outcomes RegIsTrY) is a nationwide study of pregnant or recently pregnant women who are either under investigation for Coronavirus infection (COVID-19) or have been confirmed to have COVID-19. Yalda Afshar, MD, PhD, a UCLA OBGYN maternal fetal medicine specialist, is a CO-PI on this study that is overseen by a team from UCSF and which is being done to help patients and doctors better understand how COVID-19 impacts pregnant women and their newborns. For more information > | Study flyer >


For more information about clinical trials at UCLA Obstetrics and Gynecology, please contact:

Jenny Lester, MPH, CCRP
Director of Clinical Trials
Obstetrics and Gynecology, David Geffen School of Medicine at UCLA
Phone: 310-794-9728
Email: [email protected] 

Clinical Trial Resources:

  • UCLA Office of Clinical Trials
  • UCLA Jonsson Comprehensive Cancer Center
  • For more information on clinical trials, please visit the National Cancer Institute’s website at http://www.cancer.gov/clinicaltrials
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