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UCLA Obstetrics and Gynecology

Clinical Trials

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Clinical Trials

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Featured Study:

NCI COVID-19 in Cancer Patients, NCCAPS Study

The NCI COVID-19 in Cancer Patients Study, or NCCAPS, is a natural history study of COVID-19 in people with cancer. In a natural history study, researchers follow people and collect medical and other information about them over time to learn more about how a disease and its symptoms develop and change. Diagnosis and treatment of a disease are not part of natural history studies. The knowledge gained through this study will help doctors better manage treatment for people with cancer and COVID-19 in the future. The Principal Investigators of this study are Dr. Beth Y. Karlan and Dr. Gottfrield Konecny. 
For more information >

 

The UCLA OBGYN physicians are nationally and internationally recognized not only for their clinical expertise but also for their pioneering research. Our goal is to increase basic research and translate the findings into clinical trials.

What is a clinical trial? A clinical trial is a study conducted with actual patients, usually to evaluate a new treatment. Each study is designed to answer scientific questions and to find new and better ways to help our patients.

 

Cancer - Ovarian, Fallopian Tube and Peritoneal Cancer

 

Currently Enrolling

  • Recurrent Ovarian Cancer: The Oval Study: A Randomized, Controlled, Double-Arm, Double Blind, Multi-Center Study of Ofranergene Obadenovec (VB-111) Combined with Paclitaxel vs. Paclitaxel Combined with Placebo for the Treatment of Recurrent Platinum-Resistant Ovarian Cancer
  • Recurrent Ovarian Cancer: GOG 3045: IMGN853-0416: MIRASOL: A Randomized, Open-label, Phase 3 Study of Mirvetuximab Soravtansine vs. chemo in Platinum-Resistant, Advanced High-grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers

  • Clinical Trial for the Treatment of Platinum-Sensitive Relapsed Epithelial Ovarian Cancer with Previously Received PARP Inhibitor Maintenance Treatment

 

Cancer - Uterine and Endometrial

 

Currently Enrolling

  • Testing the Addition of Pembrolizumab to Paclitaxel and Carboplatin for Endometrial Cancer

  • Radiation +/- Pembrolizumab for Newly Diagnosed, High Intermediate Risk Endometrioid Endometrial Cancer

 

Cancer - Cervical

 

Currently Enrolling

  • A Randomized, Phase 3, Double-Blind Study of Chemoradiotherapy With or Without Pembrolizumab for the Treatment of High-risk, Locally Advanced Cervical Cancer

  • Recurrent Cervical Cancer: GOG 3028: Testing AGEN2034 (ant-PD1) alone or in combination with AGEN 1884 (CTLA-4)
  • Recurrent Cervical Cancer: SKYSCRAPER:  Testing efficacy and safety of tiragolumab in combination with atezolizumab and of atezolizumab monotherapy

 

All Cancers

 

Currently Enrolling

  • NCI COVID-19 in Cancer Patients, NCCAPS Study

 

Women at High Risk for Ovarian and Breast Cancers

 

Currently Enrolling

  • A Study to Compare Two Surgical Procedures in Women With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer (NRG-CC008)

 

Benign / Non-Cancer

 

Currently Enrolling

  • Androgen Excess as a Mechanism for Adipogenic Dysfunction in PCOS Women
  • CELLEBRATE: An Adaptive, Two Stage, Double-Blind, Stratified, Randomized, Controlled Trial Comparing the Safety and efficacy of AMDC-USR with Placebo in Female Subjects with Stress Urinary Incontinence
  • Imaging Innovations for Placental Assessment in Response to Environmental Pollution (PARENTs)
  • Pudendal Nerve Block Enhancement of Enhanced Recovery After Surgery (ERAS) for Reconstructive Surgery
  • Vestibulodynia: Understanding Pathopysiology and Determing Appropriate Treatments

Research Studies

 

Currently Enrolling

  • Perinatal Mood and Behavioral Tracking Study
  • PRIORITY (Pregnancy CoRonavirus Outcomes RegIsTrY) is a nationwide study of pregnant or recently pregnant women who are either under investigation for Coronavirus infection (COVID-19) or have been confirmed to have COVID-19. Yalda Afshar, MD, PhD, a UCLA OBGYN maternal fetal medicine specialist, is a CO-PI on this study that is overseen by a team from UCSF and which is being done to help patients and doctors better understand how COVID-19 impacts pregnant women and their newborns. For more information > | Study flyer >


For more information about clinical trials at UCLA Obstetrics and Gynecology, please contact:

Jenny Lester, MPH, CCRP
Director of Clinical Trials
Obstetrics and Gynecology, David Geffen School of Medicine at UCLA
Phone: 310-794-9728
Email: jlester@mednet.ucla.edu 

Clinical Trial Resources:

  • UCLA Office of Clinical Trials
  • UCLA Jonsson Comprehensive Cancer Center
  • For more information on clinical trials, please visit the National Cancer Institute’s website at http://www.cancer.gov/clinicaltrials
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