Studies

Study Type: Interventional

The purpose of this study is to determine if dietary intervention and exercise will help you lose weight and improve your heart health. Previous research has shown an increase in risk factors for heart disease in men undergoing androgen deprivation therapy (ADT). ADT is a widely used treatment for men with prostate cancer to lower the male hormone, androgen, and to stop it from causing prostate cancer cell growth. We plan to study the effectiveness of the intervention between African Americans and non-Hispanic white men.

This study will be conducted in 2 phases (3 months each): 

• Phase I: habitual diet, where you will continue with your regular diet and exercise routine.
• Phase II: dietary intervention and exercise.

Status: Open for Enrollment

Principal Investigator:

Zhaoping Li, MD, PhD

For more information contact:

Tatiana Diacova, Clinical Study Coordinator
Email: [email protected]
Phone: 310-206-1987

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Study Type: Interventional

This research study aims to determine whether daily consumption of a bioavailable curcumin supplement can improve memory and cognitive function in adults aged 50 to 85 who experience age-related memory complaints. 

Throughout 12 months of follow-up, participants will complete cognitive assessments, questionnaires, and provide blood, urine, and stool samples to help researchers understand how curcumin may influence memory, mood, inflammation, and overall health.

Status: Coming Soon
Flyer: English

Principal Investigator:

Zhaoping Li, MD, PhD

For more information contact:

Hila Zelicha, Clinical Study Coordinator
Email: [email protected]
Phone: 310-206-8292

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Study Type: Interventional

The purpose of this study is to determine if: 

1. The daily consumption of mixed spice for 6 months leads to improved cognition, fatigue, sleep quality, and mood symptoms.
2. To explore the mechanism of how spice consumption affects cognitive, fatigue, sleep quality, and mood symptoms.

Your study participation will be expected for 6 months.

Status: Open for Enrollment
See Flyer: English

Principal Investigator:

Zhaoping Li, MD, PhD

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Study Type: Interventional

The purpose of this study is to determine if the daily consumption of 8 oz of mango compared to 1 oz of pretzel snacks for 12 weeks will: 

1. Enhance antioxidant defense of your skin by assessing the minimal dose of ultraviolet (UV) B light that irritates your skin (reddening-erythema)
2. Enhance the ability of your skin to stretch (elasticity), skin moisture (hydration), skin texture, oil secretion (sebum), and reddening (erythema)
3. Measure gene expression of genes involved in oxidative damage (caused by oxygen radicals created by UVB), collagen (structural protein) formation, and inflammation (a condition where skin becomes reddened, swollen, hot, and painful) in skin cell samples collected by skin tape stripping and blood markers for oxidative stress and inflammation.

Status: Open for Enrollment
See Flyer: English

Principal Investigator:

Zhaoping Li, MD, PhD

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Study Type: Interventional

Metformin is a drug used to treat patients with diabetes.  This study aims to examine the effect of Metformin along with a low-calorie diet on obese and/or overweight adults with an increased waist measurement. In addition, the study aims to look at the effect of the drug vs. placebo on quality of life and physical activity.

During this study, your participation will last up to 26 weeks (including screening) for a total of 8 clinic visits.  You will undergo a total of 5 blood draws, blood samples taken at screen, baseline, and weeks 8, 16, and 24.  You will also be asked to take the study drug or a placebo during the duration of this study.  You will be asked to take one capsule a day for two weeks, then increase to 2 capsules a day for the rest of the study at approximately the same time each day.

Status: Open for Enrollment
See Flyer: English

Principal Investigator:

Hila Zelicha, RD, PhD

For more information contact:

Hila Zelicha, Clinical Study Coordinator
Email: [email protected]
Phone: 310-206-8292

Tatiana Romero, Clinical Study Coordinator
Email: [email protected]
Phone: 310-825-8499

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Study Type: Interventional

The purpose of this study is to determine whether consumption of 237 ml (8 oz) of pomegranate juice daily for 8 weeks will:

1. Lower inflammation (in the gut as well as generally in the body) and improve overall quality of life
2. Affect the microbes living in the gut (gut microbiota)

Participation includes: 16 weeks with 5 in-person visits. You will be asked to drink pomegranate juice for 8 weeks and follow your habitual diet for another 8 weeks. Visits include blood, urine, and stool collection with a diet assessment.

Status: Coming Soon
See Flyer: English

Principal Investigator:

Zhaoping Li, MD, PhD

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Study Type: Interventional

The primary purpose(s) of this study are to demonstrate that:

1. The Revita DMR is superior to sham in percent change in body weight from baseline to week 24.
2. To demonstrate that a majority of Revita DMR participants maintain clinically significant weight loss after discontinuing tirzepatide therapy at 48 weeks.

Status: Closed

Principal Investigator:

Zhaoping Li, MD, PhD

For more information contact:

Jeraldine Guzman, Clinical Study Coordinator
Email: [email protected]

Study Type: Interventional

The purpose of this study is to determine if daily consumption of 2 oz of pecans compared to 3.5 oz of pretzel snacks for 12 weeks will:

1. Contribute to the body’s ability to protect itself from the potential damage caused by harmful chemical compounds produced when skin is exposed to ultraviolet (UV) light. This will be evaluated by measuring how resistant your skin, skin genes, and natural skin oils are to the damage from UV light exposure.
2. Explore the mechanisms of how snack consumption may affect aging by analyzing blood markers of aging as well as the microbes living in the gut (gut microbiome).

Participation Includes: 12 weeks with 5 in-person visits. Visits will include blood, urine, and stool collection with a diet assessment.
Status: Open for Enrollment
See Flyer: English

Principal Investigator:

Zhaoping Li, MD, PhD

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Study Type: Interventional

The goal of this investigational study is to develop algorithms that predict human response to foods. The main questions it aims to answer are: 

1. How does varying foods and eating patterns impact one’s biological and physiological responses?
2. In what ways can novel dietary assessment measures be used to improve dietary assessments and prescribe assessments to people in future research with increased precision?
3. Can artificial intelligence and machine learning techniques be combined to prescribe foods and eating patterns to individuals for optimization of their health?

There are 3 modules participants may partake in. At UCLA we offer two of the three:

Module 1: A participant’s dietary intake and accompanying nutritional status, biological and other measures, will be observed over 10 days. Physiological responses to a liquid mixed meal tolerance test will also be measured.

Module 2: Participants will undergo three controlled dietary interventions provided for 14 days each and separated by washout periods of at least 14 days. Physiological responses following a diet-specific meal test will be measured.

Status: Open for Enrollment
See Flyer: English

Principal Investigator:

Zhaoping Li, MD, PhD

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Study Type: Interventional

The purpose of this research study is to test the safety and effectiveness of the study drug, DefenCath, in reducing the risk of CLABSI as compared to heparin catheter lock solutions (CLS).

Status: Coming Soon

Principal Investigator:

Michael C. Garcia, MD

For more information contact:

Gail Thames, Clinical Study Coordinator
Email: [email protected]
Phone: 310-206-8292

Hannah Shin, Co-Investigator
Email: [email protected]
Phone: 310-206-1987

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Study Type: Interventional

This 6-month study is designed to evaluate whether dietary strategies, specifically protein supplementation and selected spices, can help reduce muscle loss during GLP-1 therapy while evaluating muscle mass, strength, and physical function.

We are recruiting adults currently using GLP-1 RAs who are experiencing a weight loss of at least 1 pound per week.

Status: Coming Soon

Principal Investigator:

Zhaoping Li, MD, PhD

For more information contact:

Hila Zelicha, Clinical Study Coordinator
Email: [email protected]
Phone: 310-206-8292

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Study Type: Interventional

The purpose of this study is to determine whether consumption of 475 ml (16 oz) of watermelon juice will:

1. Improve your cardiovascular and overall metabolic health markers such as blood pressure, heart rate, stiffness/flexibility of your arteries (blood vessels), blood sugar, cholesterol, and gut hormones
2. Contribute to the body’s ability to protect itself from the potential cell damage caused by harmful chemical compounds (produced when skin is exposed to ultraviolet (UV) B light, for example). This will be evaluated by measuring how resistant your skin is to the damage from UVB light exposure, as well as several markers of bodily stress in blood and urine.

The above will be determined immediately after consuming the juice (to evaluate the effects the juice has on your health right away), as well as after 4 weeks of daily juice consumption (to evaluate the effects the juice has on your health when consumed consistently over time).

Participation includes: 6 weeks with 4 in-person and 1 remote visit. Visits will include blood, urine, and stool collection with a diet assessment.

Status: Coming Soon
See Flyer: English

Principal Investigator:

Zhaoping Li, MD, PhD

Go to UCLA Health Clinical Trial

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