Bio of Andrea Hevener, PhD

Andrea Hevener, PhD, is an NIH-funded investigator for over two decades studying transcriptional regulation of metabolism and insulin action by hormone-responsive nuclear receptors. Dr. Hevener has extensive expertise in advancing technical and conceptual innovation in metabolism research at UCLA. She currently holds the Roberts Chair in Cellular and Molecular Endocrinology and is the basic science research director of the Iris Cantor-UCLA Women’s Health Center. Dr. Hevener is a contributing PI for an NIH-funded Specialized Center of Research Excellence award in Sex Differences and Women’s Health related to metabolism, and is a funded investigator and member of the NIH Common Fund-supported Molecular Transducers of Physical Activity Consortium (MoTrPAC). Dr. Hevener is also a driving force behind the decades-long success of the NIH funded UCSD-UCLA Diabetes Research Center, as she is involved in the center as a member of the Executive Committee, the Enrichment Core, and the director of the Metabolic and Molecular Physiology Core (MMPC). Dr. Hevener mentors trainees across all research stages in a variety of venues at UCLA and the Southern California region, including the NIDDK-funded LIFT-UP program -  Leveraging Institutional Support for Talented, Underrepresented Physicians and/or Scientists.

Dr. Hevener’s laboratory has made important advances in our understanding of estrogen action and estrogen receptor (ER) biology in metabolic tissues. Her research is focused on understanding the tissue-specific target genes of action, as well as the cellular processes controlled by ERs. Much of her research has shown that ERalpha plays a critical role in mitochondrial remodeling, oxidative metabolism, and quality control. Dr. Hevener’s research team interrogates the impact of ERalpha loss and gain of gene expression in a variety of cells and tissue types including skeletal and cardiac muscle, adipose tissue, immune cells, and liver. Her laboratory has determined how impairment of estrogen action contributes to cardiometabolic-related diseases and certain forms of cancer, and identified the beneficial effects of heightened ERalpha action to combat metabolic dysfunction and diet-induced insulin resistance. Similar to this work, her team has advanced the fundamental understanding of the molecular mechanisms that underlie the metabolic health benefits of daily physical activity.

Headshot of Andrea Hevener in Black Blazer
  • Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice.
    Moore TM, Lee S, Olsen T, Morselli M, Strumwasser AR, Lin AJ, Zhou Z, Abrishami A, Garcia SM, Bribiesca J, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQA, Anand ATS, Yackly A, Mendoza LQ, Leyva BK, Aliman C, Artiga DJ, Meng Y, Charugundla S, Pan C, Jedian V, Seldin MM, Ahn IS, Diamante G, Blencowe M, Yang X, Mouisel E, Pellegrini M, Turcotte LP, Birkeland KI, Norheim F, Drevon CA, Lusis AJ, Hevener AL. Cell Rep. 2023 May 30;42(5):112499. doi: 10.1016/j.celrep.2023.112499. Epub 2023 May 12. PMID: 37178122 Free article.
  • Leveraging genetic correlation structure to target discrete signaling mechanisms across metabolic tissues.
    Zhou M, Van C, Molendijk J, Chang IY, Johnson C, Velez LM, Yeo RX, Bae H, Le J, Larson N, Pulido R, Nascimento-Filho CHV, Hevener A, Sparks LM, Justice JN, Kershaw EE, Marazzi I, Pannunzio N, Nicholas D, Parker B, Jang C, Masri S, Seldin M. bioRxiv. 2023 May 12:2023.05.10.540142. doi: 10.1101/2023.05.10.540142. Preprint. PMID: 37214953 Free PMC article.
  • The mitochondrial multi-omic response to exercise training across tissues.
    Amar D, Gay NR, Jimenez-Morales D, Jean Beltran PM, Ramaker ME, Raja AN, Zhao B, Sun Y, Marwaha S, Gaul D, Hershman SG, Xia A, Lanza I, Fernandez FM, Montgomery SB, Hevener AL, Ashley EA, Walsh MJ, Sparks LM, Burant CF, Rector RS, Thyfault J, Wheeler MT, Goodpaster BH, Coen PM, Schenk S, Bodine SC, Lindholm MNE; MoTrPAC Study Group. bioRxiv. 2023 Jan 13:2023.01.13.523698. doi: 10.1101/2023.01.13.523698. Preprint. PMID: 36711881 Free PMC article.
  • Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes.
    Moore TM, Cheng L, Wolf DM, Ngo J, Segawa M, Zhu X, Strumwasser AR, Cao Y, Clifford BL, Ma A, Scumpia P, Shirihai OS, Vallim TQA, Laakso M, Lusis AJ, Hevener AL, Zhou Z. Nat Commun. 2022 Nov 4;13(1):6661. doi: 10.1038/s41467-022-34468-2. PMID: 36333379 Free PMC article.
  • Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.
    Wang Z, Emmerich A, Pillon NJ, Moore T, Hemerich D, Cornelis MC, Mazzaferro E, Broos S, Ahluwalia TS, Bartz TM, Bentley AR, Bielak LF, Chong M, Chu AY, Berry D, Dorajoo R, Dueker ND, Kasbohm E, Feenstra B, Feitosa MF, Gieger C, Graff M, Hall LM, Haller T, Hartwig FP, Hillis DA, Huikari V, Heard-Costa N, Holzapfel C, Jackson AU, Johansson Å, Jørgensen AM, Kaakinen MA, Karlsson R, Kerr KF, Kim B, Koolhaas CM, Kutalik Z, Lagou V, Lind PA, Lorentzon M, Lyytikäinen LP, Mangino M, Metzendorf C, Monroe KR, Pacolet A, Pérusse L, Pool R, Richmond RC, Rivera NV, Robiou-du-Pont S, Schraut KE, Schulz CA, Stringham HM, Tanaka T, Teumer A, Turman C, van der Most PJ, Vanmunster M, van Rooij FJA, van Vliet-Ostaptchouk JV, Zhang X, Zhao JH, Zhao W, Balkhiyarova Z, Balslev-Harder MN, Baumeister SE, Beilby J, Blangero J, Boomsma DI, Brage S, Braund PS, Brody JA, Bruinenberg M, Ekelund U, Liu CT, Cole JW, Collins FS, Cupples LA, Esko T, Enroth S, Faul JD, Fernandez-Rhodes L, Fohner AE, Franco OH, Galesloot TE, Gordon SD, Grarup N, Hartman CA, Heiss G, Hui J, Illig T, Jago R, James A, Joshi PK, Jung T, Kähönen M, Kilpeläinen TO, Koh WP, Kolcic I, Kraft PP, Kuusisto J, Launer LJ, Li A, Linneberg A, Lua… See abstract for full author list  Nat Genet. 2022 Sep;54(9):1332-1344. doi: 10.1038/s41588-022-01165-1. Epub 2022 Sep 7. PMID: 36071172 Free PMC article.
  • Genetic variation of putative myokine signaling is dominated by biological sex and sex hormones.
    Velez LM, Van C, Moore T, Zhou Z, Johnson C, Hevener AL, Seldin MM. Elife. 2022 Apr 13;11:e76887. doi: 10.7554/eLife.76887. PMID: 35416774 Free PMC article.
  • ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity.
    Shum M, Shintre CA, Althoff T, Gutierrez V, Segawa M, Saxberg AD, Martinez M, Adamson R, Young MR, Faust B, Gharakhanian R, Su S, Chella Krishnan K, Mahdaviani K, Veliova M, Wolf DM, Ngo J, Nocito L, Stiles L, Abramson J, Lusis AJ, Hevener AL, Zoghbi ME, Carpenter EP, Liesa M. Sci Transl Med. 2021 May 19;13(594):eabd1869. doi: 10.1126/scitranslmed.abd1869. PMID: 34011630 Free PMC article.
  • A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.
    Zempo H, Kim SJ, Fuku N, Nishida Y, Higaki Y, Wan J, Yen K, Miller B, Vicinanza R, Miyamoto-Mikami E, Kumagai H, Naito H, Xiao J, Mehta HH, Lee C, Hara M, Patel YM, Setiawan VW, Moore TM, Hevener AL, Sutoh Y, Shimizu A, Kojima K, Kinoshita K, Arai Y, Hirose N, Maeda S, Tanaka K, Cohen P. Aging (Albany NY). 2021 Jan 19;13(2):1692-1717. doi: 10.18632/aging.202529. Epub 2021 Jan 19. PMID: 33468709 Free PMC article.
  • ERα in the Control of Mitochondrial Function and Metabolic Health.
    Hevener AL, Ribas V, Moore TM, Zhou Z. Trends Mol Med. 2021 Jan;27(1):31-46. doi: 10.1016/j.molmed.2020.09.006. Epub 2020 Oct 2. PMID: 33020031 Review.
  • Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge. 
    Moore TM, Zhou Z, Strumwasser AR, Cohn W, Lin AJ, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Hoang AN, Widjaja K, Abrishami AD, Charugundla S, Stiles L, Whitelegge JP, Turcotte LP, Wanagat J, Hevener AL. Aging Cell. 2020 Nov;19(11):e13166. doi: 10.1111/acel.13166. Epub 2020 Oct 13. PMID: 33049094 Free PMC article.
  • Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling.
    Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. Sci Transl Med. 2020 Aug 5;12(555):eaax8096. doi: 10.1126/scitranslmed.aax8096. PMID: 32759275 Free PMC article.
  • The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle.
    Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL. Mol Metab. 2019 Mar;21:51-67. doi: 10.1016/j.molmet.2018.11.012. Epub 2018 Dec 4. PMID: 30591411 Free PMC article.