Pisegna Molecular Genetics and Physiology Laboratory
Key investigators
Joseph Pisegna, MD
Patrizia M. Germano, MD
Suwan Oh, PhD
Funding
NIH/NCI M3LD Study subaward - “Gut-related markers and hepatocellular cancer risk in a multi-ethnic cirrhotic cohort"
VA Merit Review - Gastrointestinal Hormonal Regulation of Obesity Project F-7219R
VA Cooperative Study CSP 577 Confirm Trial
NIH NIDDK U01 Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Clinical Centers (CSCPDPC -CCs -RFA-DK-14-027) - “Pathophysiology, Epidemiology, and Prevention of Pancreatogenic Diabetes”
Diacomp NIH NIDDK/Emory University Pisegna, PI - “Role of the Vagus Nerve in Regulating Diabetes and Metabolic Syndrome"
Research funding
BX004560-01, 01/01/201912/31/2023, Veterans Affairs Merit Review, CMA: Cancer Stem Cells in the Pathogenesis and Treatment of Colorectal Cancer
1R21 CA225623-01, 03/01/2018-02/29/2020, NIH/NCI Identification of Microbial Biomarkers for Hepatocellular Carcinoma in a Multi-Ethnic Population of Patients with Nonalcoholic Fatty Liver Disease (NAFLD)
R01 CA204145 07/22/2016-06/30/2021, NIH/NCI Gut-Related Markers and Hepatocellular Cancer in a Multi-Ethnic Cirrhotic Cohort
U01, 01/01/2016-12/30/2021, NIH/NIDDK Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Clinical Centers (CSCPDPC -CCs -RFA-DK-14-027)
CSP 577 Confirm Trial 10/01/2012-09/30/2027, VA Cooperative Study investigating FIT vs screening colonoscopy
Current research projects
Evaluation of the role of high protein dietary intervention in metabolic syndrome
Evaluation of the role of high protein dietary intervention in hepatic steatosis
Role of PACAP in metabolic syndrome
Role of PACAP and VIP in mouse models of colitis
Role of VIP in metabolic syndrome and hepatic steatosis
GWAS studies in colonic polyps, NAFLD and NASH
Pathophysiology, epidemiology and prevention of pancreatogenic diabetes
Pathophysiology of gastrin and VIP on the regulation of gastric and renal function
Future research directions
Genetic basis for metabolic syndrome, NAFLD and NASH
Pathophysiological basis for hormone and receptors to regulate gastrointestinal function
Neuroendocrine tumor-pathophysiology and genetic basis
Gastrointestinal regulation of renal physiologic function
Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan I, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267.doi: 10.1126/scitranslmed.abk2267
Calais J, Czernin J, Eiber M, Fendler WP, Gartmann J, Heaney A, Hendifar A, Pisegna J, Hecht JR, Wolin E, Slavik R, Gupta P, Quon A, Schiepers C, Allen-Auerbach M, Herrmann K. Most Intended Management Changes after 68-Ga-DOTATATE PET/CT are ImplementedJ Nucl Med. 2017 May 4. pii: jnumed.117.192450. doi: 10.2967/jnumed.117.192450. PMID:28473600
