Kaunitz Laboratory

Key investigators

• Jonathan D. Kaunitz, MD
• Yasutada Akiba, MD, PhD

Funding

• VA Merit
• Shire Pharmaceuticals

Current research projects

• Mechanisms of endotoxin uptake from the gut
• Prevention of acute pancreatitis complications
• Targeted treatment of metabolic disease

Future research directions

• Metabolite activation of gut chemosensory mechanisms in the treatment of acute and chronic endotoxin-related disease
• Novel treatments for IBS
• Novel treatments for secretory diarrhea

Key publications

1. Hollander D, Kaunitz JD. The “Leaky Gut”: Tight Junctions but Loose Associations? Digestive Diseases and Sciences (2020) 65:1277–1287 https://doi.org/10.1007/s10620-019-05777-2. Editorial.
2. Bhattarai Y, Williams BB, Battaglioli EJ, Whitaker WR, Till L, Grover M, Linden DR, Akiba Y, Kandimalla KK, Zachos NC, Kaunitz JD, Sonnenburg JL, Fischbach MA, Farrugia G, Kashyap PC. Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion. Cell Host Microbe. 2018 Jun 13;23(6):775-785.e5
3. Kaji I, Akiba Y, Furuyama T, Adelson DW, Iwamoto K, Watanabe M, Kuwahara A, Kaunitz JD. Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon. Neurogastroenterol Motil. 2018 Jan;30(1).
4. Iwasaki M, Akiba Y, Kaunitz JD. Duodenal chemosensing. Curr Opin Gastroenterol. 2018 Aug 18.
5. Kaji I, Kaunitz JD. Luminal chemosensing in the gastroduodenal mucosa. Curr Opin Gastroenterol. 2017 Nov;33(6):439-445
6. Said H, Akiba Y, Narimatsu K, Maruta K, Kuri A, Iwamoto KI, Kuwahara A, Kaunitz JD. FFA3 Activation Stimulates Duodenal Bicarbonate Secretion and Prevents NSAID-Induced Enteropathy via the GLP-2 Pathway in Rats. Dig Dis Sci. 2017 Aug;62(8):1944-1952.
7. Kaji I, Akiba Y, Furuyama T, Adelson DW, Iwamoto K, Watanabe M, Kuwahara A, Kaunitz JD. Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon. Neurogastroenterol Motil. 2017 Jul
8. Akiba Y, Maruta K, Narimatsu K, Said H, Kaji I, Kuri A, Iwamoto KI, Kuwahara A, Kaunitz JD. FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats. Am J Physiol Gastrointest Liver Physiol. 2017 May
9. Kaji I, Akiba Y, Kato I, Maruta K, Kuwahara A, Kaunitz JD. Xenin Augments Duodenal Anion Secretion via Activation of Afferent Neural Pathways. J Pharmacol Exp Ther. 2017 361:151-161.
10. Berg CJ, Kaunitz JD. Gut chemosensing: implications for disease pathogenesis. F1000Res. 2016 30;5:2424.
11. Said H, Kaunitz JD. Gastrointestinal defense mechanisms. Curr Opin Gastroenterol. 2016 Nov;32(6):461-466.
12. Kaji I, Akiba Y, Konno K, Watanabe M, Kimura S, Iwanaga T, Kuri A, Iwamoto K, Kuwahara A, Kaunitz JD. Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon. J Physiol. 2016 15;594:3339-52.
13. Kaji I, Akiba Y, Said H, Narimatsu K, Kaunitz JD. Luminal 5-HT stimulates colonic bicarbonate secretion in rats. Br J Pharmacol. 2015 172:4655-70.
14. Akiba Y, Kaunitz JD, Higuchi K. The effects of a TGR5 agonist and a dipeptidyl peptidase IV inhibitor on dextran sulfate sodium-induced colitis in mice. J Gastroenterol Hepatol. 2015 30 Suppl 1:60-5.
15. Fujiwara K, Inoue T, Yorifuji N, Iguchi M, Sakanaka T, Narabayashi K, Kakimoto K, Nouda S, Okada T, Ishida K, Abe Y, Masuda D, Takeuchi T, Fukunishi S, Umegaki E, Akiba Y, Kaunitz JD, Higuchi K. Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration. J Clin Biochem Nutr. 2015 56:155-62.