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Limketkai Laboratory
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Sternini Laboratory
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Beaven Laboratory
Benhammou Laboratory
Dong Laboratory
Gupta Laboratory
Familial Mediterranean Fever Laboratory
Han Laboratory
Hemostasis Research
Health Services Research
Hepatology Research
Hsiao Laboratory
Interventional Endoscopy Research
Jacob Laboratory
Jacobs Laboratory
Joshi Laboratory
Kaunitz Laboratory
Koon Laboratory
Limketkai Laboratory
May Laboratory
Mulugeta Laboratory
Patel Laboratory
Pisegna Laboratory
Rozengurt Laboratory
Saab Laboratory
Sachs Laboratory
Sternini Laboratory
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Kaunitz Laboratory
Kaunitz Laboratory
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Key investigators
Jonathan D. Kaunitz, MD
Yasutada Akiba, MD, PhD
Funding
VA Merit
Shire Pharmaceuticals
Current research projects
Mechanisms of endotoxin uptake from the gut
Prevention of acute pancreatitis complications
Targeted treatment of metabolic disease
Future research directions
Metabolite activation of gut chemosensory mechanisms in the treatment of acute and chronic endotoxin-related disease
Novel treatments for IBS
Novel treatments for secretory diarrhea
Key publications -
Full list on PubMed
Hollander D, Kaunitz JD.
The “Leaky Gut”: Tight Junctions but Loose Associations?
Digestive Diseases and Sciences
(2020) 65:1277–1287 https://doi.org/10.1007/s10620-019-05777-2. Editorial.
Bhattarai Y, Williams BB, Battaglioli EJ, Whitaker WR, Till L, Grover M, Linden DR, Akiba Y, Kandimalla KK, Zachos NC, Kaunitz JD, Sonnenburg JL, Fischbach MA, Farrugia G, Kashyap PC.
Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion
.
Cell Host Microbe
. 2018 Jun 13;23(6):775-785.e5
Kaji I, Akiba Y, Furuyama T, Adelson DW, Iwamoto K, Watanabe M, Kuwahara A, Kaunitz JD.
Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon
.
Neurogastroenterol Motil
. 2018 Jan;30(1).
Iwasaki M, Akiba Y, Kaunitz JD.
Duodenal chemosensing
.
Curr Opin Gastroenterol
. 2018 Aug 18.
Kaji I, Kaunitz JD.
Luminal chemosensing in the gastroduodenal mucosa
.
Curr Opin Gastroenterol
. 2017 Nov;33(6):439-445
Said H, Akiba Y, Narimatsu K, Maruta K, Kuri A, Iwamoto KI, Kuwahara A, Kaunitz JD.
FFA3 Activation Stimulates Duodenal Bicarbonate Secretion and Prevents NSAID-Induced Enteropathy via the GLP-2 Pathway in Rats
.
Dig Dis Sci
. 2017 Aug;62(8):1944-1952.
Kaji I, Akiba Y, Furuyama T, Adelson DW, Iwamoto K, Watanabe M, Kuwahara A, Kaunitz JD.
Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon
.
Neurogastroenterol Motil
. 2017 Jul
Akiba Y, Maruta K, Narimatsu K, Said H, Kaji I, Kuri A, Iwamoto KI, Kuwahara A, Kaunitz JD.
FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats
.
Am J Physiol Gastrointest Liver Physiol
. 2017 May
Kaji I, Akiba Y, Kato I, Maruta K, Kuwahara A, Kaunitz JD.
Xenin Augments Duodenal Anion Secretion via Activation of Afferent Neural Pathways
.
J Pharmacol Exp Ther
. 2017 361:151-161.
Berg CJ, Kaunitz JD.
Gut chemosensing: implications for disease pathogenesis
.
F1000Res
. 2016 30;5:2424.
Said H, Kaunitz JD.
Gastrointestinal defense mechanisms
.
Curr Opin Gastroenterol
. 2016 Nov;32(6):461-466.
Kaji I, Akiba Y, Konno K, Watanabe M, Kimura S, Iwanaga T, Kuri A, Iwamoto K, Kuwahara A, Kaunitz JD.
Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon
.
J Physiol
. 2016 15;594:3339-52.
Kaji I, Akiba Y, Said H, Narimatsu K, Kaunitz JD.
Luminal 5-HT stimulates colonic bicarbonate secretion in rats
.
Br J Pharmacol
. 2015 172:4655-70.
Akiba Y, Kaunitz JD, Higuchi K.
The effects of a TGR5 agonist and a dipeptidyl peptidase IV inhibitor on dextran sulfate sodium-induced colitis in mice
.
J Gastroenterol Hepatol
. 2015 30 Suppl 1:60-5.
Fujiwara K, Inoue T, Yorifuji N, Iguchi M, Sakanaka T, Narabayashi K, Kakimoto K, Nouda S, Okada T, Ishida K, Abe Y, Masuda D, Takeuchi T, Fukunishi S, Umegaki E, Akiba Y, Kaunitz JD, Higuchi K.
Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration
.
J Clin Biochem Nutr
. 2015 56:155-62.
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