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Menopause: Symptoms, Treatment, Diagnosis

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What is Menopause?

Menopause is defined as the point in time when menstrual cycles permanently cease due to the natural depletion of ovarian oocytes from aging. The diagnosis is typically made retrospectively after the woman has missed menses for 12 consecutive months. It marks the permanent end of fertility and the average age of menopause is 51 years.


Menopause Diagnosis

Although the diagnosis can be made by the patient’s history, laboratory testing may be performed to confirm the diagnosis of menopause. Elevated follicle stimulating hormone (FSH) and low estrogen (estradiol) are consistent with menopause. Any hormonal therapy, such as birth control pills, will invalidate the FSH and estradiol tests. Because certain medical conditions can result in the lack of menses, your doctor may also check your thyroid function, prolactin level, and possibly other tests based on your history and physical examination.

Symptoms of Menopause

Since menopause is due to the depletion of ovarian follicles/oocytes and severely reduced functioning of the ovaries, it is associated with lower levels of reproductive hormones, especially estrogen. Low estrogen can result in vasomotor instability (such as hot flushes and night sweats), psychological changes (such as mood swings, depression, and difficulty concentrating), insomnia, genital tract atrophy (such as vaginal dryness, painful intercourse, and urinary incontinence), skin changes (such as thinning and decreased elasticity). Lower androgen levels (male hormones) can contribute to the loss of sex drive. Any abnormal vaginal bleeding should be reported immediately to your doctor, since this may represent a precancerous or cancerous condition of the uterus or endometrial lining.

Later Medical Problems

The lower reproductive hormones associated with menopause will increase the risk of osteoporosis, bone fractures, and cardiovascular disease (such as myocardial infarction and stroke).

Treatment Options

Treatment for Menopause

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A healthy lifestyle including a nutritious diet, supplementation with vitamin D and calcium, regular weight bearing exercise, and elimination of cigarettes and alcohol can help lower your risk of osteoporosis, bone fractures, and cardiovascular disease. Hormone replacement therapy consists of estrogen, progesterone, and possibly testosterone may help alleviate or reduce the menopausal symptoms. However, it is recommended to use the lowest possible dose for the shortest duration possible to reduce the risks of breast cancer, blood clots, myocardial infarction, and stroke. Non-hormonal medications for vasomotor instability include low dose selective serotonin reuptake inhibitor (SSRI) antidepressants (such as fluoxetine, paroxetine, citalopram, and sertraline), gabapentin, and clonidine. The effects of increased dietary intake of phytoestrogens (such as soybeans, chickpeas, and flaxseed) on vasomotor relief are controversial and there is some concern about cancer risk due to weak estrogen-like effects. Osteoporosis can also be treated with non-hormonal bisphosphonates (such as alendronate, risedronate, and ibandronate) or selective estrogen receptor modulators (SERMs; such as raloxifene). Please discuss these treatment options with your doctor before beginning any specialized treatment plan.

General Health Maintenance

Menopausal medicine includes general health screening, including pelvic examination with PAP smear, clinical breast exam, mammography, dual-emission X-ray absorptiometry ( DEXA) to screen for osteoporosis, fecal occult blood testing, sigmoidoscopy/colonoscopy, and blood tests including lipid and thyroid screening.

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