The Epeldegui Laboratory seeks an Assistant Project Scientist to join our dynamic group and perform basic scientific research in the areas of immunology, cancer and HIV/AIDS.
Dr. Epeldegui’s research focuses on the role of immune dysfunction and cancer, especially AIDS-associated B cell non-Hodgkin lymphoma (ARL). ARL remains a significant problem even in the era of combination anti-retroviral treatment (cART). Her research work and others have shown that B cell activation and microbial translocation precede the development of ARL, with elevated levels of biomarkers associated with B cell activation and microbial translocation seen prior to ARL diagnosis. Moreover, biomarkers of inflammation, B cell activation and microbial translocation are also associated with cancer prognosis. Her laboratory studies how inflammation, microbial translocation, viral infections and other events may lead to lymphomagenesis and pathogenesis of ARL.
Dr. Epeldegui has also shown that HIV infected individuals have elevated levels of B-regulatory cells that express programmed death ligand 1 (PD-L1) prior to ARL diagnosis. In addition, ARL patients have elevated levels of exosomes bearing PD-L1, and other molecules associated with B cell immune activation, before cancer treatment. This arm of research focuses on investigating the role of exosomes and their association with prognostic biomarkers of ARL.
Applicants must possess a Ph.D. degree or equivalent in an appropriate biological field of study to apply. Candidates must also have at least 6 years for experience focusing on cancer biology and immunology. Candidates are expected to have a strong background in immunology, virology, molecular and cell biology and have experience with basic molecular biology techniques (RNA and DNA analysis, PCR, RT-qPCR, protein analysis, Western immunoblotting, and ELISA), flow cytometry, mass cytometry, exosome extraction and characterization from various sources (cell culture, human serum or plasma), and proteomics. The candidate must have prior training and direct experience with sterile technique and cell culture of human cells (immortalized cell lines and primary cells), training and extensive experience with BSL-2+ laboratory practices, and must be able to work with clinical specimens, handle and process human tissue samples, and have experience with humanized animal model systems.
The successful candidate should be self-motivated, be able to work independently, and have publications in peer-reviewed journals. The candidate would also be expected to: design and perform experiments; develop, adapt, and implement new research techniques and protocols; analyze and interpret results from large data sets (e.g. flow cytometry, mass cytometry, imaging mass cytometry, RNA-seq, and proteomics); train undergraduates and/or graduate students; assist in the preparation of grant proposals but is not responsible for generating grant funds; prepare manuscripts for publications; and have the ability to supervise multiple projects simultaneously.
Interested candidates can apply online through the UC Recruit system.
For more information about the position or general inquiries, please contact Dr. Marta Epeldegui at [email protected].
The G.O. Discovery Laboratory at the University of California, Los Angeles (UCLA) invites applications for a Project Scientist at the Assistant, Associate or Full Project Scientist level. The laboratory is affiliated with the UCLA Eli and Edythe Broad Cell Research Center, Jonsson Comprehensive Cancer Center, and the Molecular Biology Institute. This appointment will be under the supervision of Professor Sanaz Memarzadeh, M.D., Ph.D., a gynecologic oncologist and molecular biologist in the Department of Obstetrics and Gynecology at the UCLA David Geffen School of Medicine.
The candidate will be expected to make significant and creative contributions to the study of two epithelial gynecologic cancers, ovarian and endometrial cancer. The work will focus on understanding mechanisms of resistance to standard chemo- and immune therapies in addition to studying normal cells that could be precursors to either cancer type. This position requires a Ph.D. or M.D./Ph.D. degree in basic sciences. Candidates are expected to have experience with molecular biology, cell based studies, in vivo assays, microscopy, immunohistochemistry, FACS analysis, pharmacology ,virology, and immunology. Experience with small animal surgical procedures are strongly preferred.
The level of appointment will be commensurate with the applicant’s qualifications.
Interested candidates can apply through the UC Recruit system.
Information regarding the G.O. Discovery Laboratory >
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