CURE Hemostasis Research Group
Gareth Dulai, MD, MSHS
Kevin Ghassemi, MD
Rome Jutabha, MD
Thomas Kovacs, MD
Gustavo Machicado, MD
James Sul, MD, MSEpi
Marc Kaneshiro, MD
Stephen Kim, MD
Alireza Sedarat, MD
V. Raman Muthusamy, MD, MAS
NIH-NIDDK. Gastroenterology Training Grant (T32)
CURE Digestive Diseases Research Center (DDRC), Human Studies CORE
VA Clinical Merit Review Grant
ASGE Research Foundation Grant
Medtronic Investigator Initiated Research Grant
Current research projects
Randomized Controlled Trial (RCT) of a large over-the-scope hemoclip compared to standard endoscopic hemostasis for patients with severe non-variceal UGI bleeding
RCT of Doppler assisted risk stratification and hemostasis compared to GI guideline management to prevent severe delayed post-polypectomy induced ulcer (PPIU) hemorrhage in high risk patients
Database, retrospective cohort studies and prospective RCT of Dieulafoy’s lesions as a cause of severe UGI, small intestine, or colon hemorrhage
Retrospective cohort study of long term outcomes of patients with UGI bleeding from watermelon stomach or portal hypertensive gastropathy treated with MPEC vs. APC
Cohort study of the accuracy of CT scans for detection of esophagogastric varices in patients with severe UGI hemorrhage
Prospective study of urgent capsule endoscopy for localization and diagnosis of patients with severe hematochezia
Future research directions
Multicenter study of OVESCO vs. standard endoscopic hemostasis for severe ulcer and Dieulafoy’s lesion hemorrhage
Multicenter study of Doppler assisted endoscopic risk stratification and hemostasis to prevent delayed bleeding after EMR or polypectomy in the colon, stomach or duodenum in high risk patients
RCT of Cryotherapy vs. APC for control of chronic GI bleeding in patients with watermelon stomach or portal hypertensive gastropathy
Cohort study of delayed EMR or post-polypectomy hemorrhage after resection of UGI benign polyps
Cost analyses of OTSC and PPIU RCT’s when enrollment is completed
Diagnosis and Treatment of Definitive Diverticular Hemorrhage. Amer J Gastroenterol 2018: In Press Sung JJY, Chiu P, Chan FK, Lau JYW, Goh KL, Ho KY, Jung HY, Sollano JD, Gotoda T, Reddy N, Singh R, Sugano K, Wu KC, Wuc Y, Bjorkmau DJ, Jensen DM, Kuipers EJ, Lanas A.
Asian-Pacific Working Group Consensus on Non-variceal Upper Gastrointestinal Bleeding. An Update 2018. Gut 2018; 0:1-12.doi: 10.1136/gutjn1-2018 Manatsathit W, Jensen DM, Hines J, Kovacs T, Ohning G, Jutabha R, Ghassemi K, Dulai GS, Machicado G.
Laparotomy and intraoperative enteroscopy for severe obscure gastrointestinal bleeding before and after the era of video capsule endoscopy and deep enteroscopy. Amer J Surgery 2017: In Press Jensen DM, Kovacs TOG, Ohning GV, Ghassemi K, Machicado GA, Dulai GS, Sedarat A, Jutabha R, Gornbein J.
Doppler Endoscopic Probe Monitoring for Blood Flow Improves Risk Stratification and Outcomes of Patients with Severe Non-Variceal UGI Hemorrhage. Gastroenterology 2017; 152:1310-1318 Jensen DM, Eklund S, Persson, T, Ahlbom H, Stuart R, Barkun AN, Kuipers EJ, Mössner J, Lau JY, Sung, JJ, Kilhamm J, Lind T.
Reassessment of Rebleeding Risk of Forrest IB (Oozing) Peptic Ulcer Bleeding in a Large International Randomized Trial. Am J Gastroenterol 2017; 112:441-446 Camus-Duboc M, Khungar V, Jensen DM, Ohning GV, Kovacs TOG, Jutabha R, Ghassemi, K, Machicado GA, Dulai GS.
Origin, Clinical Characteristics and 30-day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics. Dig Dis Sc 2016; 61:2732-40 Camus M, Jensen DM, Kovacs TOG, Jensen ME, Markovic D, Gornbein J.
Independent Risk Factors of 30 day Outcomes in 1264 patients with Peptic Ulcer Bleeding in the USA – Large Ulcers do worse. Alim Pharm Ther 2016; 43:1080-1089 Jensen DM, Ohning GV, Kovacs TOG, Ghassemi K, Jutabha R, Dulai GS, Machicado GA.
Doppler Endoscopic probe as a guide to risk stratification and definitive hemostasis of peptic ulcer bleeding. Gastrointest Endosc 2016;83: 129-36 Jensen DM, Ohning GV, Kovacs TOG, Jutabha R, Ghassemi K, Machicado GA, Dulai GS.
Natural History of Definitive Diverticular Hemorrhage Based Upon Stigmata of Recent Hemorrhage and Doppler Blood Flow Monitoring for Risk Stratification and Definitive Hemostasis. Gastrointest Endosc 2016;83:416-23 Camus M, Jensen DM, Ohning GV, Kovacs TO, Ghassemi KA, Jutabha R, Machicado GA, Dulai GS, Jensen ME, Gornbein JA.
Comparison of 3 Risk Scores to Predict Outcomes of Severe Lower Gastrointestinal Bleeding. J Clin Gastroenterol 2016; 50:52-58 Camus M, Jensen DM, Ohning GV, Kovacs TO, Ghassemi KA, Jutabha R, Machicado GA, Dulai GS., Hines JO.
Severe Upper Gastrointestinal Hemorrhage from Linear Gastric Ulcers in Large Hiatal Hernias: a Large Prospective Case, Series of Cameron Ulcers. Endoscopy 2013; 45:1-4 Laine L, Jensen DM. ACG Guideline.
Management of Patients with Ulcer Bleeding. Am J Gastroenterol 2012; 107:345-360 Chavalitdhamrong D, Jensen DM, Singh B, Kovacs TOG, Carrico M, Han SH, Durazo F, Saab S, Gornbein JA.
Is capsule endoscopy accurate enough to screen cirrhotic patients for varices and other lesions? Gastrointestinal Endoscopy 2008 Volume 67, Issue 5, Page AB122
Past GI research fellows
Marine Camus, MD
Disaya Chavalitdhamrong, MD
Daniel Eshtiaghpour, MD
M. Philip Fejleh, MD
Marie-Anne Guillaumot, MD
Vandana Khungar, MD, MSc
Shane Manatsathit, MD
Neil Marya, MD
Benjamin Nulsen, MD
Alireza Sedarat, MD
Current clinical GI research fellows
Rudolph V. Schindler Award (2012) - Dr. Dennis Jensen was the recipient of the American Society of Gastrointestinal Endoscopy (ASGE)
Rudolph V. Schindler Award. This Schindler Award is the society's highest honor, recognizing the person whose accomplishments in endoscopic research, teaching or service to the society exemplifies the standardss of Dr. Schindler.