Hemostasis Research

Research group

• CURE Hemostasis Research Group

Principal investigator

• Dennis M. Jensen, MD

Co-investigators

• Gareth Dulai, MD, MSHS
• Kevin Ghassemi, MD
• Rome Jutabha, MD
• Thomas Kovacs, MD
• Gustavo Machicado, MD
• James Sul, MD, MSEpi
• Marc Kaneshiro, MD
• Stephen Kim, MD
• Alireza Sedarat, MD
• V. Raman Muthusamy, MD, MAS

Funding

• NIH-NIDDK. Gastroenterology Training Grant (T32)
• CURE Digestive Diseases Research Center (DDRC), Human Studies CORE
• VA Clinical Merit Review Grant
• ASGE Research Foundation Grant
• Medtronic Investigator Initiated Research Grant

Current research projects

• Randomized Controlled Trial (RCT) of a large over-the-scope hemoclip compared to standard endoscopic hemostasis for patients with severe non-variceal UGI bleeding
• RCT of Doppler assisted risk stratification and hemostasis compared to GI guideline management to prevent severe delayed post-polypectomy induced ulcer (PPIU) hemorrhage in high risk patients
• Database, retrospective cohort studies and prospective RCT of Dieulafoy’s lesions as a cause of severe UGI, small intestine, or colon hemorrhage
• Retrospective cohort study of long term outcomes of patients with UGI bleeding from watermelon stomach or portal hypertensive gastropathy treated with MPEC vs. APC
• Cohort study of the accuracy of CT scans for detection of esophagogastric varices in patients with severe UGI hemorrhage
• Prospective study of urgent capsule endoscopy for localization and diagnosis of patients with severe hematochezia
  
  

Future research directions

• Multicenter study of OVESCO vs. standard endoscopic hemostasis for severe ulcer and Dieulafoy’s lesion hemorrhage
• Multicenter study of Doppler assisted endoscopic risk stratification and hemostasis to prevent delayed bleeding after EMR or polypectomy in the colon, stomach or duodenum in high risk patients
• RCT of Cryotherapy vs. APC for control of chronic GI bleeding in patients with watermelon stomach or portal hypertensive gastropathy
• Cohort study of delayed EMR or post-polypectomy hemorrhage after resection of UGI benign polyps
• Cost analyses of OTSC and PPIU RCT’s when enrollment is completed
  
  

Key publications

1. Jensen DM. Diagnosis and Treatment of Definitive Diverticular Hemorrhage. Amer J Gastroenterol 2018: In Press
2. Sung JJY, Chiu P, Chan FK, Lau JYW, Goh KL, Ho KY, Jung HY, Sollano JD, Gotoda T, Reddy N, Singh R, Sugano K, Wu KC, Wuc Y, Bjorkmau DJ, Jensen DM, Kuipers EJ, Lanas A. Asian-Pacific Working Group Consensus on Non-variceal Upper Gastrointestinal Bleeding. An Update 2018. Gut 2018; 0:1-12.doi: 10.1136/gutjn1-2018
3. Manatsathit W, Jensen DM, Hines J, Kovacs T, Ohning G, Jutabha R, Ghassemi K, Dulai GS, Machicado G. Laparotomy and intraoperative enteroscopy for severe obscure gastrointestinal bleeding before and after the era of video capsule endoscopy and deep enteroscopy. Amer J Surgery 2017: In Press
4. Jensen DM, Kovacs TOG, Ohning GV, Ghassemi K, Machicado GA, Dulai GS, Sedarat A, Jutabha R, Gornbein J. Doppler Endoscopic Probe Monitoring for Blood Flow Improves Risk Stratification and Outcomes of Patients with Severe Non-Variceal UGI Hemorrhage. Gastroenterology 2017; 152:1310-1318
5. Jensen DM, Eklund S, Persson, T, Ahlbom H, Stuart R, Barkun AN, Kuipers EJ, Mössner J, Lau JY, Sung, JJ, Kilhamm J, Lind T. Reassessment of Rebleeding Risk of Forrest IB (Oozing) Peptic Ulcer Bleeding in a Large International Randomized Trial. Am J Gastroenterol 2017; 112:441-446
6. Camus-Duboc M, Khungar V, Jensen DM, Ohning GV, Kovacs TOG, Jutabha R, Ghassemi, K, Machicado GA, Dulai GS. Origin, Clinical Characteristics and 30-day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics. Dig Dis Sc 2016; 61:2732-40
7. Camus M, Jensen DM, Kovacs TOG, Jensen ME, Markovic D, Gornbein J. Independent Risk Factors of 30 day Outcomes in 1264 patients with Peptic Ulcer Bleeding in the USA – Large Ulcers do worse. Alim Pharm Ther 2016; 43:1080-1089
8. Jensen DM, Ohning GV, Kovacs TOG, Ghassemi K, Jutabha R, Dulai GS, Machicado GA. Doppler Endoscopic probe as a guide to risk stratification and definitive hemostasis of peptic ulcer bleeding. Gastrointest Endosc 2016;83: 129-36
9. Jensen DM, Ohning GV, Kovacs TOG, Jutabha R, Ghassemi K, Machicado GA, Dulai GS. Natural History of Definitive Diverticular Hemorrhage Based Upon Stigmata of Recent Hemorrhage and Doppler Blood Flow Monitoring for Risk Stratification and Definitive Hemostasis. Gastrointest Endosc 2016;83:416-23
10. Camus M, Jensen DM, Ohning GV, Kovacs TO, Ghassemi KA, Jutabha R, Machicado GA, Dulai GS, Jensen ME, Gornbein JA. Comparison of 3 Risk Scores to Predict Outcomes of Severe Lower Gastrointestinal Bleeding. J Clin Gastroenterol 2016; 50:52-58
11. Camus M, Jensen DM, Ohning GV, Kovacs TO, Ghassemi KA, Jutabha R, Machicado GA, Dulai GS., Hines JO. Severe Upper Gastrointestinal Hemorrhage from Linear Gastric Ulcers in Large Hiatal Hernias: a Large Prospective Case, Series of Cameron Ulcers. Endoscopy 2013; 45:1-4
12. Laine L, Jensen DM. ACG Guideline. Management of Patients with Ulcer Bleeding. Am J Gastroenterol 2012; 107:345-360
13. Chavalitdhamrong D, Jensen DM, Singh B, Kovacs TOG, Carrico M, Han SH, Durazo F, Saab S, Gornbein JA. Is capsule endoscopy accurate enough to screen cirrhotic patients for varices and other lesions? Gastrointestinal Endoscopy 2008 Volume 67, Issue 5, Page AB122

Past GI research fellows

• Marine Camus, MD
• Disaya Chavalitdhamrong, MD
• Daniel Eshtiaghpour, MD
• M. Philip Fejleh, MD
• Marie-Anne Guillaumot, MD
• Vandana Khungar, MD, MSc
• Shane Manatsathit, MD
• Neil Marya, MD
• Benjamin Nulsen, MD
• Alireza Sedarat, MD

Awards

• Rudolph V. Schindler Award (2012) - Dr. Dennis Jensen was the recipient of the American Society of Gastrointestinal Endoscopy (ASGE) Rudolph V. Schindler Award. This Schindler Award is the society's highest honor, recognizing the person whose accomplishments in endoscopic research, teaching or service to the society exemplifies the standardss of Dr. Schindler.
  

More information

• CURE: Digestive Diseases Research Center
• NIH T32 Training Grant