Pisegna Molecular Genetics and Physiology Laboratory
Key Investigators
- Joseph Pisegna, MD
- Patrizia M. Germano, MD
- Suwan Oh, PhD
Funding
- NIH/NCI M3LD Study subaward - “Gut-related markers and hepatocellular cancer risk in a multi-ethnic cirrhotic cohort"
- VA Merit Review - Gastrointestinal Hormonal Regulation of Obesity Project F-7219R
- VA Cooperative Study CSP 577 Confirm Trial
- NIH NIDDK U01 Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Clinical Centers (CSCPDPC -CCs -RFA-DK-14-027) - “Pathophysiology, Epidemiology, and Prevention of Pancreatogenic Diabetes”
- Diacomp NIH NIDDK/Emory University Pisegna, PI - “Role of the Vagus Nerve in Regulating Diabetes and Metabolic Syndrome"
Current Research Projects
- Evaluation of the role of high protein dietary intervention in metabolic syndrome
- Evaluation of the role of high protein dietary intervention in hepatic steatosis
- Role of PACAP in metabolic syndrome
- Role of PACAP and VIP in mouse models of colitis
- Role of VIP in metabolic syndrome and hepatic steatosis
- GWAS studies in colonic polyps, NAFLD and NASH
- Pathophysiology, epidemiology and prevention of pancreatogenic diabetes
- Pathophysiology of gastrin and VIP on the regulation of gastric and renal function
Future Research Directions
- Genetic basis for metabolic syndrome, NAFLD and NASH
- Pathophysiological basis for hormone and receptors to regulate gastrointestinal function
- Neuroendocrine tumor-pathophysiology and genetic basis
- Gastrointestinal regulation of renal physiologic function
Key Publications
- Wang L, Jacobs JP, Lagishetty V, Yuan PQ, Million M, Reeve JR, Pisegna J and Tache Y High protein diet promotes sensitity to cholecystokinin and shifts the cecal microbiome without altering brain inflammation in diet induced obesity in rats. Am J Physiol Regul Integr Comp Physiol 2017 Jul 19.
- Calais J, Czernin J, Eiber M, Fendler WP, Gartmann J, Heaney A, Hendifar A, Pisegna J, Hecht JR, Wolin E, Slavik R, Gupta P, Quon A, Schiepers C, Allen-Auerbach M, Herrmann K. Most Intended Management Changes after 68-Ga-DOTATATE PET/CT are Implemented J Nucl Med. 2017 May 4. pii: jnumed.117.192450. doi: 10.2967/jnumed.117.192450. PMID:28473600
- Li R, Yang J, Saffari A, Jacobs J, Baek KI, Hough G, Larauche MH, Ma J, Jen N, Moussaoui N, Zhou B, Kang H, Reddy S, Henning SM, Campen MJ, Pisegna J, Li Z, Fogelman AM, Sioutas C, Navab M, Hsiai TK. Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites. Sci Rep. 2017 Feb 17;7:42906. PMID: 28211537
- Benhammou JN, Phan J, Lee H, Ghassemi K, Parsons W, Grody WW, Pisegna JR. A Sodium Channel Myotonia Presenting with Intermittent Dysphagia as a Manifestation of a Rare SCN4A Variant. J Mol Neurosci. 2016 Dec 23. doi: 10.1007/s12031-016-0878-5.PMID:28012096.
- Padua D, Mahurkar-Joshi S, Law I, Polytarchou C, Vu J, Pisegna J, Shih D, Iliopolous D, and Pothoulakis C A Long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation. American Journal of Physiology 2016 311(3):G446-57.
- Wang J, Benhammou JN, Ghassemi K, Kim S, Pisegna JR (2017) Endoscopic Ultrasound-Guided Fine Needle Aspiration Accurately Diagnoses Smaller Pancreatic Neuroendocrine Tumors Compared To Computer Tomography-Guided Fine Needle Aspiration. Gastroenterol Pancreatol Liver Disord 4(2): 1-7.
- Padua D, Vu JP, Germano PM, Pisegna JR. The Role of Neuropeptides in Mouse Models of Colitis. J Mol Neurosci. 2016 Jun;59(2):203-10. doi: 10.1007/s12031-015-0688-1. Epub 2015 Dec 8. Review.PMID:26646243
- Vu JP, Goyal D, Luong L, Oh S, Sandhu R, Norris J, Parsons W, Pisegna JR, Germano P. PACAP intraperitoneal treatment suppresses appetite and food intake via PAC1 receptor in mice, by inhibiting ghrelin and increasing GLP-1 and leptin. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 3:ajpgi.00190.2015. doi: 10.1152/ajpgi.00190.2015. [Epub ahead of print]
- Vu JP, Larauche M, Flores M, Luong L, Norris J, Oh S, Liang LJ, Waschek J, Pisegna JR, Germano PM. Regulation of Appetite, Body Composition, and Metabolic Hormones by Vasoactive Intestinal Polypeptide (VIP). J Mol Neurosci. 2015 Jun;56(2):377-87.
- Vu JP, Million M, Larauche M, Luong L, Norris J, Waschek JA, Pothoulakis C, Pisegna JR, Germano PM. Inhibition of vasoactive intestinal polypeptide (VIP) induces resistance to dextran sodium sulfate (DSS)-induced colitis in mice. J Mol Neurosci. 2014 Jan;52(1):37-47.
Past GI Research Fellows
- Joon Ki Choi, MD
- Arpana Gupta, PhD
- Deepinder Goyal, MD
- Sang Le, MD
- Edward Lee, MD, MS
- Elizabeth Marcus, MD
- Rong-Ming Lyu, PhD
- Hank Wang, MD, MS
- Emily Whang, MD
- Ning Zeng, MD, PhD
Current GI Research Fellows
- Jihane Benhammou, MD
- Noam Jacob, MD
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