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Heart Failure Research

At UCLA, we seek to excel in patient care, research, and education in our quest to push the boundaries of medical care. As we seek to advance the medical field, we understand that the future of patient care can only be improved with asking questions and work towards solutions with people who have a common goal.

Below are listed our current trials that are actively enrolling patients. Other trials can be located on the website.

Active and Enrolling

Title: A Double-blind, Randomized, Sham–procedure–controlled, Parallel-group Efficacy and Safety Study of Allogeneic Mesenchymal Precursor Cells (rexlemestrocel-L) in Patients with Chronic Heart Failure Due to Left Ventricular Systolic Dysfunction of Either Ischemic or Nonischemic Etiology (DREAM HF)

PurposeThis is a study of an experimental study product cells called rexlemestrocel-L, which consists of Mesenchymal Precursor Cells (or MPCs). These cells are special cells that were obtained from the bone marrow of a healthy person or donor who donated bone marrow for the purpose of this study. The donor was tested carefully for many diseases to minimize the possibility that a disease would be passed on to you, the recipient. The cells were isolated from the healthy person’s bone marrow, further purified and then grown outside the donor’s body in order to increase the number of cells. The final purified cells are then stored in a frozen sterile container until they are used for injection. The cells will be thawed and then warmed to room temperature before they are used.

The purpose of this research study is to determine if the injection of the MPCs into the heart muscle with a specific type of needle can help restore heart muscle function in patients with heart failure.

Principal InvestigatorAli Nsair, MD

TitleInvestigation to Optimize Hemodynamic of HeartMate II Left Ventricular Assist Device Patients using the CardioMEMS Pulmonary Artery Pressure Sensor in Advanced Heart Failure.  (INTELLECT 2)

Purpose: This observational post market study is intended to characterize hemodynamic-guided management of patients with an existing left ventricular device( LVAD) to protocol specified target ranges and its impact on functional status , quality of life, and readmissions.

Principal Investigator: Ali Nsair, MD

Title: International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

Purpose: Determine the best management strategy for higher-risk patients with stable ischemic heart disease, compatient routine invasive strategy with optimal medical therapy vs. optimal medical therapy alone

Principal Investigator: Gabriel Vorobiof, MD

Title: Tasso HemoLink Study

Purpose: Assessment of HemoLink-collected blood for lipid panel measurements on point-of-care analyzers

Principal Investigator: Eric Yang, MD

Active Not Enrolling

Title: Affordability and Real-world Antiplatelet Treatment Effectiveness After Myocardial Infarction Study (ARTEMIS)

Purpose: Whether co-payment reduction leads to improved outcomes.

Principal Investigator: Eric Yang, MD

Title: Edoxaban Compared to Standard Care After Heart Valve Replacement Using a Catheter in Patients With Atrial Fibrillation (ENVISAGE-TAVI AF)

Purpose: Evaluate safety and efficacy of edoxoban compared to coumadin in patients with atrial fibrillation who are undergoing transcatheter aortic valve replacement

Principal Investigator: Olcay Aksoy, MD

Sub-Principal Investigator: William Suh, MD

Recently Closed Studies

Title: Effect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy (LIBERTY-HCM)

Purpose: Evaluate GS-6615 in patients who have hypertrophic obstructive cardiomyopathy

Principal Investigator: Eugene DePasquale, MD

Title: Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF

Purpose: Evaluate use of intravenous infusion of serelaxin when added to standard therapy in acute heart failure

Principal Investigator: Arnold Baas, MD

Archive Studies

Title: PREMIUM Migraine Trial

Purpose: Evaluate impact of Patent Foramen Ovale Closure using Amplatzer PFO occluder in the treatment of patients with migraines

Principal Investigator: Jonathan Tobis, MD

Title: RESPECT PFO Clinical Trial

Purpose: Evaluate impact of Patent Foramen Ovale Closure using Amplatzer PFO occluder in the treatment of patients who have a history of stroke

Principal Investigator: Jeffrey Saver, MD

Co-Principal Investigator: Jonathan Tobis, MD

Title: Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34+ Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina (RENEW)

Purpose: Evaluate impact of Stem Cell injections in patients with coronary artery disease and refractory angina

Principal Investigator: Ali Nsair, MD

Co-Principal Investigator: Jonathan Tobis, MD