Digestive Diseases

To view our openings for the division of Digestive Diseases, please see the listings below:

 

Posted November 15, 2022

The Division of Digestive Diseases in the Department of Medicine at the David Geffen School of Medicine at UCLA invites applications for a faculty position at the level of Instructor, Assistant, Associate, and full Professor ranks. The candidate must have a strong commitment towards expanding our current Inflammatory Bowel Disease (IBD) ambulatory and inpatient practice with interest in both clinical research and teaching students and trainees, including the development of an IBD fellowship program. The position involves participating at the Westwood site.

The candidate should have strong communication skills, a patient-centered approach to clinical care, and an interest in collaborating on scholarly activities. Preference will be given to those with previous experience in IBD care. Leadership opportunities will be available in clinical practice and education based on experience of the candidate. Applicants must be board certified/board eligible Gastroenterologist with specialized expertise in IBD. Applicant must have an M.D./D.O. with completion of internal medical residency and gastroenterology fellowship from an ACGME-accredited program. We are seeking applicants who have had an extra fellowship year specializing in IBD.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

All aspects of searches are confidential and all candidates are expected to review and abide by UC Regents Policy 1111 on Statement on Ethical Values and Standards of Conduct https://regents.universityofcalifornia.edu/governance/policies/1111.html.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07944


Posted October 5, 2022

The Digestive Diseases in the Department of Medicine at the David Geffen School of Medicine is seeking applicants for a Project Scientist position. The Jacobs Lab is seeking candidates with significant past experience supervising research staff in biomedical research laboratories. It will involve providing assistance to Jacobs Laboratory staff upon their request to troubleshoot experimental protocols. It does not involve direct bench work or a direct supervisory role for any staff in the laboratory. A Ph.D. in biomedical research is required.

Duties include the following: 

  • DNA/RNA extraction
  • PCR amplification
  • Amplicon and metagenomics sequencing
  • Immunohistochemistry 
  • Flow cytometry
  • Cell culture
  • Protein measurement by ELISA

Skills, Knowledge and Abilities:

  • Ability to use a personal computer and basic computer applications.
  • Ability to organize and present results in an appropriate format.
  • Ability to maintain complete and accurate records.
  • Able to read and understand scientific protocols.
  • Good oral and written communication skills in English.
  • Excellent interpersonal and verbal communication skills.
  • 1 year experience supervising technicians, graduate students, and postdoctoral fellows. 

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07890


Posted October 5, 2022

The Division of Digestive Diseases in the Department of Medicine at the David Geffen School of Medicine at UCLA invites applications for a faculty position at the level of Instructor, Assistant, Associate, and full Professor ranks. The candidate must have a strong commitment towards expanding our current Inflammatory Bowel Disease (IBD) ambulatory and inpatient practice with interest in both clinical research and teaching students and trainees, including the development of an IBD fellowship program. The position involves participating at the Westwood site.

The candidate should have strong communication skills, a patient-centered approach to clinical care, and an interest in collaborating on scholarly activities. Preference will be given to those with previous experience in IBD care. Leadership opportunities will be available in clinical practice and education based on experience of the candidate. Applicants must be board certified/board eligible Gastroenterologist with specialized expertise in IBD. Applicant must have an M.D./D.O. with completion of internal medical residency and gastroenterology fellowship from an ACGME-accredited program. We are seeking applicants who have had an extra fellowship year specializing in IBD.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

All aspects of searches are confidential and all candidates are expected to review and abide by UC Regents Policy 1111 on Statement on Ethical Values and Standards of Conduct https://regents.universityofcalifornia.edu/governance/policies/1111.html.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07944


Posted September 8, 2022

The Laboratory of Autophagy and Integrative Physiology in the Department of Medicine, Division of Digestive Diseases at the David Geffen School of Medicine at UCLA is seeking a full time Post-Doctoral Research Fellow to focus on the mechanisms by which autophagy degrades lipid droplets in liver. The Post-Doctoral Research Fellow will apply complementary approaches including isolation of autophagosomes and autolysosomes and late endosomes as well as super-resolution microscopy to determine the mechanisms of sequestration of lipid cargo by the autophagy pathway in murine liver and cultured hepatocytes. The position will offer excellent opportunity to advance career path and to obtain training in tissue fractionation and biochemical cell biological approaches, super-resolution microscopy, proteomics, genetic interventions in mouse models, and mammalian physiology.

The applicant will work directly with Nuria Martinez-Lopez, PhD and Rajat Singh, MD, MBBS, and an array of faculty collaborators across UCLA, and beyond. There will be many opportunities to lead high impact publications and working with a diverse, collaborative, and a highly motivated research team. Extensive mentorship will be provided to facilitate the transition to an independent research career.

Responsibilities will include, but are not limited to:

  • Confocal and super-resolution microscopy.
  • Isolation of various autophagic and lysosomal fractions and lipid droplets from murine livers.
  • Various biochemical approaches such as Co-IP and Western blotting, and gene expression analyses.
  • Analyses of data, preparation of manuscripts, and presentations of findings at meetings, etc.

Required Qualifications:
Ph.D. is required. Candidates with some experience in autophagy and an understanding of the pathobiology of fatty liver disease will be preferred. Candidate with some experiences in these approaches will receive top priority.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.


To apply, please visit:  https://recruit.apo.ucla.edu/JPF07841


Posted September 8, 2022

The Laboratory of Autophagy and Integrative Physiology in the Department of Medicine, Division of Digestive Diseases at UCLA is seeking a full time Post-Doctoral Research Fellow to focus on the mechanisms by which late endosomal microautophagy degrades lipid droplets in the liver. The Post-Doctoral Research Fellow will apply complementary approaches including isolation of late endosomes and lipid droplets as well as use super-resolution microscopy to determine the mechanisms of sequestration of lipid cargo by late endosomes in murine liver and cultured hepatocytes. The position will offer excellent opportunity to advance career path and to obtain training in biochemical cell biological approaches, super-resolution microscopy, proteomics, genetic interventions in mouse models, and mammalian physiology.

The applicant will work directly with Nuria Martinez-Lopez, PhD and Rajat Singh, MD, MBBS, and an array of faculty collaborators across UCLA, and beyond.
There will be many opportunities to lead high impact publications and working with a diverse, collaborative, and a highly motivated research team. Extensive mentorship will be provided to facilitate the transition to an independent research career.

The Post-Doctoral Fellow’s responsibilities will include, but are not limited to:

  • Isolation of various subcellular fractions and lipid droplets from murine livers.
  • Various biochemical approaches such as Co-IP and Western blotting, and gene expression analyses.
  • Confocal and super-resolution microscopy.
  • Analyses of data, preparation of manuscripts, and presentations of findings at meetings, etc.

Required Qualifications:
A Ph.D. is required. Candidates with some experience in autophagy and an understanding of the pathobiology of fatty liver disease will be preferred. Candidate with some experiences in these approaches will receive top priority.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07842


Posted September 8, 2022

The Laboratory of Autophagy and Integrative Physiology in the Department of Medicine, Division of Digestive Diseases at UCLA is seeking a full time Postdoctoral Scholar to understand the brain regions that sense lipids and the mechanisms by lipids are sensed in the CNS, and how these signals are integrated with peripheral energy and lipid metabolism. The Postdoctoral Scholar will also engage in circadian studies to assess how changing meal timing impacts systemic lipid and energy metabolism. The Postdoctoral Scholar will apply complementary approaches including collection of brains and processing them via iDISCO and visualizing regions via confocal microscopy. Additional approaches will include bulk and scRNAseq in the CNS and peripheral tissues to broadly understand downstream mechanisms of lipid sensing. The position will offer excellent opportunity to advance career path and to train in various biochemical, imaging-based, and physiological approaches, and provide training to various junior students and fellows in the lab.

The applicant will work directly with Rajat Singh, MD, MBBS, and an array of faculty collaborators across UCLA, and beyond. There will be many opportunities to lead high impact publications and working with a diverse, collaborative, and a highly motivated research team. Extensive mentorship will be provided to facilitate the transition to an independent research career.

The Postdoctoral Scholar's responsibilities will include, but are not limited to:

  • Isolating brains and applying clarity methods to visualize lipid sensing regions in the brain
  • Using various biochemical approaches to understand circadian mechanisms regulating metabolism.
  • Assisting in establishing the various dietary intervention models tested in the lab.
  • Confocal and super-resolution microscopy.
  • Analyses of data, preparation of manuscripts, and presentations of findings at meetings, etc.
  • Training junior lab members.

Required Qualifications:
A Ph.D. with a minimum of 3-4 years of postdoctoral research experience. Candidates with some experience in autophagy and an understanding of systemic metabolism will be preferred. Candidate with some experiences in these approaches will receive top priority.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07849


Posted August 9, 2022

The Brain-Gut Interaction Laboratory, CURE/Digestive Disease Research Center in the Division of Digestive Diseases at the University of California Los Angeles is seeking a full time Post-Doctoral Research Fellow for a project funded through the NIH OT2 SPARC (Stimulating Peripheral Activity to Relieve Conditions) initiative. The research project is focused on 3D imaging and computational quantitation of extrinsic and intrinsic innervation and nerve-mast/glial cell spatial relationship in the human colonic mucosa for neuromodulation in patients with irritable bowel syndrome (IBS).

The Post-Doctoral Research Fellow will apply cutting-edge technologies and softwares related to confocal microscopy, imaging, 3D reconstruction, tracing and segmentation by using Imaris and Neurolucida to quantitate extrinsic and intrinsic innervation of IBS phenotypes in relation with MCs-EGCs spatial configuration in 3D structure of the sigmoid colonic biopsies in healthy controls and IBS patients, assess sex differences and correlation with IBS symptom severity. 

Position will offer excellent opportunity to advance career path and to obtain training in technologies and softwares related to CLARITY, confocal microscopy, imaging, 3D reconstruction, tracing and segmentation by using Imaris and Neurolucida. There will also be opportunities to develop translational and clinical neuroscience research skills. 

The applicant will work directly with Pu-Qing Yuan, Ph.D. and Yvette Taché, Ph.D. and array of faculty collaborators across UCLA, and beyond. 

There will be many opportunities to lead high impact publications starting on day one, working with existing rich and unique datasets in addition to creating new ones. Extensive mentorship will be provided to facilitate the transition to an independent research career.

Duties and Responsibilities:

The Post-Doctoral Fellow’s responsibilities will include, but are not limited to:

  • CLARITY, immunohistochemistry, confocal microscopy, imaging, 3D reconstruction.
  • Tracing and quantitation of nerve innervation by using Imaris and Neurolucida.
  • Data analysis
  • Prepare manuscripts

Required Qualifications:

A Ph.D. and/or M.D. with 0-3 years of postdoctoral research experience. Candidates with some experience and interest in neuroanatomical and immunohistolochemical studies of the enteric nerve system and autonomic nervous system will be preferred. Candidate with some experiences in these approaches will receive top priority.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star. 

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07727


Posted July 26, 2022

The laboratory of Professor Michael Koon in the UCLA Department of Medicine, Division of Digestive Diseases is seeking a full-time postdoctoral fellow. The focuses of the Koon Lab are on Crohn’s disease-associated intestinal fibrosis, C. difficile infection, obesity, and diabetes. 

The Koon Lab is developing orally active formulations to treat gastrointestinal and metabolic diseases. These formulations include metabolites, small molecules, and microbiota. Dr. Koon has five active grants, including a new NIH R01 grant and collaboration with industry. The lab has current projects to discover efficacies and mechanisms of action of therapeutic agents as well as exploring new therapeutic approaches and biomarkers for various diseases. The Koon Lab works with mouse models, human blood and tissue, and cell and enteroid cultures. Please see the Koon Lab webpage to understand more: https://www.uclahealth.org/gastro/research/koon-lab

Specific techniques used in the lab include:

  • Molecular biology: gene knockdown and overexpression, qPCR, western blot, ELISA
  • Immunocytochemistry, immunohistochemistry, fluorescence, and brightfield microscopy
  • Use of automated microscopy for high-content screening.
  • Measurement of intestinal permeability and identifying tight junctions.
  • Bacterial cultures
  • Assessment of immune phenotype
  • Bioinformatic analysis of high-throughput transcriptomic data, proteomics, and microbiome data
  • Building machine learning algorithms for performing complex analyses
  • Mouse models: dissection of the gut, testing of blood cells, cytokines, and biochemistry, measurement of gene and protein expression, preparation of gut tissue for immunohistochemistry, preparation of gut organoids

Responsibilities will include

  • Running projects independently
  • Supervision of undergraduate and medical students
  • Interact with various units and staff to handle tasks
  • Maintaining and organizing lab inventory
  • Management of mouse and hamster colonies and study cohort
  • Management of biohazardous and chemical hazard materials.
  • Maintenance of cell cultures
  • Writing of research papers and grant applications

The ideal candidate will have multidisciplinary expertise and creativity to initiate new projects from concept to publication. The candidate will also quickly learn new skills and knowledge to adapt to changing environments. First year Ph.D. graduates are preferred. Please see the Koon Lab webpage to understand more: https://www.uclahealth.org/gastro/research/koon-lab

The start date is flexible, but the postdoctoral fellow should join within the 2022 calendar year.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star. 

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.


To apply, please visit:  https://recruit.apo.ucla.edu/JPF07708


Posted July 19, 2022

The Jacobs Laboratory in the UCLA Microbiome Center and the Division of Digestive Diseases, Department of Medicine at the David Geffen School of Medicine at UCLA, is seeking applicants for a post-doctoral position in microbiome science. The laboratory studies the role of intestinal microbes in inflammatory bowel disease (IBD) and other gastrointestinal diseases using a combination of multi-omics analysis of human cohorts to define microbiome-phenotype associations and in vivo models to elucidate underlying biological mechanisms.

The candidate will investigate the hypothesis that IBD-associated genetic variants disrupt pathways that regulate the intestinal microbiota, thereby creating a microbial pre-disease susceptibility state. This will be pursued through the use of gene edited and conditional knockout mice to model the effect of IBD-associated genetic variants on the microbiome. The relevance of these microbial shifts will be further investigated through the use of gnotobiotic mice colonized with human or mouse microbiota.

A PhD is required. Applicants must have extensive experience using animal models and molecular biology techniques in their prior scientific projects. Direct experience with microbiome research is welcome but not required. Prior bioinformatics exposure is not necessary.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07678


Posted July 19, 2022

The Division of Digestive Diseases in the Department of Medicine at the David Geffen School of Medicine at UCLA and the VA Greater Los Angeles Health System are seeking applicants for a full-time Postdoctoral Scholar position in the Stress-Neurogastroenterology laboratory. The candidate will participate in projects involving anatomical profiling of neuronal circuits in the pelvic organs-autonomic nervous system, using tracing, immunohistochemistry, image reconstruction and molecular biology assays. The position will offer the candidate an excellent opportunity to advance their career path and to obtain training in new methodological approaches.

A PhD, DVM or MD is required with some experience and interest in neuroanatomical and immunohistochemical studies and in microscopy and imaging processing. Knowledge and experiences preferred in autonomic nervous system, microscopy, and image processing. The candidate must be enthusiastic, have strong written and oral communication skills, be highly motivated, intellectually creative, able to work independently, and function well as part of a team. Candidates will be expected to contribute to ongoing projects and expand novel independent research projects in a collaborative research environment.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07679


Posted July 19, 2022

The Center for Neurobiology of Stress and Resilience in the Division of Digestive Diseases at the University of California Los Angeles is seeking a full time Post-Doctoral Research Fellow for a U54-funded project studying sex-related differences in the brain-gut-microbiome interactions related to visceral pain. This project is focused on the sex-specific effect of gut microbial metabolites, and estrogen levels on ascending arousal pathways originating in distinct brainstem nuclei to change the activity and connectivity of brain networks involved in symptom generation in irritable bowel syndrome. As a part of an multidisciplinary research team the fellow will apply advanced computational, neuroimaging, biostatistical, and bioinformatics approaches to assess the interaction between various levels of biological data (e.g., microbiota, metabolites, sex hormones, multimodal brain and brainstem imaging data), clinical variables (symptom severity, widespread pain) and sex. There will be opportunities to develop translational and clinical neuroscience research skills (e.g., target discovery, individualized treatment development and biomarker/predictor development), in addition to state-of-the-art analytical skills to address basic and pathophysiological systems biology questions.

The G Oppenheimer Center for Neurobiology of Stress and Resilience (CNSR) is an interdisciplinary, translational Center funded by the National Institutes of Health, and by philanthropic support. The overall research goals of the CNSR are to better understand the interactions between mind brain and body in health and disease, and to develop novel management strategies for optimal health and for complex chronic disorders. Center investigators are conducting clinical, translational and basic research with human populations, using interventions (e.g., diet, cognitive behavioral therapy) alongside deep phenotyping including neuroimaging, mutli-omics profiling (gut microbiome, metabolomics, inflammatory biomarkers, psychosocial and behavioral assessments. You will work directly with Arpana “Annie” Gupta, PhD and Jennifer Labus, PhD and an array of faculty collaborators across UCLA, and beyond. There will be many opportunities to lead high impact publications starting on day one, working with existing rich and unique datasets in addition to creating new ones. Extensive mentorship will be provided to facilitate the transition to an independent research career.

Duties and Responsibilities:

The Post-Doctoral Fellow’s responsibilities will include, but are not limited to:

  • Develop longitudinal multimodal MRI data analysis streams (functional connectivity, task-based fMRI, diffusion tractography and volumetrics).
  • Analyze complex multi-omics datasets including imaging, gut microbiome, metabolomics, behavioral and clinical data.
  • Prepare and submit manuscripts
  • Mentor graduate and undergraduate students
  • Be inquisitive, curious and publish!

Required Qualifications:

  • Ph.D. in Neuroscience, Neuropsychology, Bioinformatics, Biostatistics, Engineering, Computer Science or a related field.
  • Strong proficiency and independence with various neuroimaging analysis platforms, multivariate modeling strategies and network connectivity analyses.
  • Established quantitative and statistical skills, including strong programming skills and comfort with diverse computing environments. Experience with R, Linux, Matlab or Python preferred.
  • Background in systems/cognitive neuroscience, neuroanatomy and psychological/clinical constructs.
  • A demonstrated capacity to drive first author publications.
  • Excellent communication and writing skills, motivated and driven to publish.

Preferred Qualifications:

  • Connectomics network analysis and machine learning modeling confer a very significant advantage.
  • Management/coding of neuroimaging databases (XNAT or others).

Additional Information:
This is a 2 to 3-year term position with great opportunities for training in human systems biology, translational/clinical applications and diverse integrated methodologies. Expected start date: Summer/Fall 2022

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07683


Posted July 12, 2022

The Division of Digestive Diseases in the Department of Medicine at the David Geffen School of Medicine at UCLA invites applications for a faculty position at the level of Instructor, Assistant, Associate, and full Professor ranks. The position involves participating in gastroenterology practices located at various UCLA sites in Los Angeles County. Duties include direct patient care in the inpatient and outpatient setting and teaching medical students, residents, and fellows. An MD or DO is required. Applicants must be board eligible or board certified in Internal Medicine and board eligible or board certified in Gastroenterology. Active California medical license is required.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

All aspects of searches are confidential and all candidates are expected to review and abide by UC Regents Policy 1111 on Statement on Ethical Values and Standards of Conduct https://regents.universityofcalifornia.edu/governance/policies/1111.html.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07622