Digestive Diseases

To view our openings for the division of Digestive Diseases, please see the listings below:

 

Posted July 19, 2022

The Jacobs Laboratory in the UCLA Microbiome Center and the Division of Digestive Diseases, Department of Medicine at the David Geffen School of Medicine at UCLA, is seeking applicants for a post-doctoral position in microbiome science. The laboratory studies the role of intestinal microbes in inflammatory bowel disease (IBD) and other gastrointestinal diseases using a combination of multi-omics analysis of human cohorts to define microbiome-phenotype associations and in vivo models to elucidate underlying biological mechanisms.

The candidate will investigate the hypothesis that IBD-associated genetic variants disrupt pathways that regulate the intestinal microbiota, thereby creating a microbial pre-disease susceptibility state. This will be pursued through the use of gene edited and conditional knockout mice to model the effect of IBD-associated genetic variants on the microbiome. The relevance of these microbial shifts will be further investigated through the use of gnotobiotic mice colonized with human or mouse microbiota.

A PhD is required. Applicants must have extensive experience using animal models and molecular biology techniques in their prior scientific projects. Direct experience with microbiome research is welcome but not required. Prior bioinformatics exposure is not necessary.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07678


Posted July 19, 2022

The Division of Digestive Diseases in the Department of Medicine at the David Geffen School of Medicine at UCLA and the VA Greater Los Angeles Health System are seeking applicants for a full-time Postdoctoral Scholar position in the Stress-Neurogastroenterology laboratory. The candidate will participate in projects involving anatomical profiling of neuronal circuits in the pelvic organs-autonomic nervous system, using tracing, immunohistochemistry, image reconstruction and molecular biology assays. The position will offer the candidate an excellent opportunity to advance their career path and to obtain training in new methodological approaches.

A PhD, DVM or MD is required with some experience and interest in neuroanatomical and immunohistochemical studies and in microscopy and imaging processing. Knowledge and experiences preferred in autonomic nervous system, microscopy, and image processing. The candidate must be enthusiastic, have strong written and oral communication skills, be highly motivated, intellectually creative, able to work independently, and function well as part of a team. Candidates will be expected to contribute to ongoing projects and expand novel independent research projects in a collaborative research environment.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07679


Posted July 19, 2022

The Center for Neurobiology of Stress and Resilience in the Division of Digestive Diseases at the University of California Los Angeles is seeking a full time Post-Doctoral Research Fellow for a U54-funded project studying sex-related differences in the brain-gut-microbiome interactions related to visceral pain. This project is focused on the sex-specific effect of gut microbial metabolites, and estrogen levels on ascending arousal pathways originating in distinct brainstem nuclei to change the activity and connectivity of brain networks involved in symptom generation in irritable bowel syndrome. As a part of an multidisciplinary research team the fellow will apply advanced computational, neuroimaging, biostatistical, and bioinformatics approaches to assess the interaction between various levels of biological data (e.g., microbiota, metabolites, sex hormones, multimodal brain and brainstem imaging data), clinical variables (symptom severity, widespread pain) and sex. There will be opportunities to develop translational and clinical neuroscience research skills (e.g., target discovery, individualized treatment development and biomarker/predictor development), in addition to state-of-the-art analytical skills to address basic and pathophysiological systems biology questions.

The G Oppenheimer Center for Neurobiology of Stress and Resilience (CNSR) is an interdisciplinary, translational Center funded by the National Institutes of Health, and by philanthropic support. The overall research goals of the CNSR are to better understand the interactions between mind brain and body in health and disease, and to develop novel management strategies for optimal health and for complex chronic disorders. Center investigators are conducting clinical, translational and basic research with human populations, using interventions (e.g., diet, cognitive behavioral therapy) alongside deep phenotyping including neuroimaging, mutli-omics profiling (gut microbiome, metabolomics, inflammatory biomarkers, psychosocial and behavioral assessments. You will work directly with Arpana “Annie” Gupta, PhD and Jennifer Labus, PhD and an array of faculty collaborators across UCLA, and beyond. There will be many opportunities to lead high impact publications starting on day one, working with existing rich and unique datasets in addition to creating new ones. Extensive mentorship will be provided to facilitate the transition to an independent research career.

Duties and Responsibilities:

The Post-Doctoral Fellow’s responsibilities will include, but are not limited to:

  • Develop longitudinal multimodal MRI data analysis streams (functional connectivity, task-based fMRI, diffusion tractography and volumetrics).
  • Analyze complex multi-omics datasets including imaging, gut microbiome, metabolomics, behavioral and clinical data.
  • Prepare and submit manuscripts
  • Mentor graduate and undergraduate students
  • Be inquisitive, curious and publish!

Required Qualifications:

  • Ph.D. in Neuroscience, Neuropsychology, Bioinformatics, Biostatistics, Engineering, Computer Science or a related field.
  • Strong proficiency and independence with various neuroimaging analysis platforms, multivariate modeling strategies and network connectivity analyses.
  • Established quantitative and statistical skills, including strong programming skills and comfort with diverse computing environments. Experience with R, Linux, Matlab or Python preferred.
  • Background in systems/cognitive neuroscience, neuroanatomy and psychological/clinical constructs.
  • A demonstrated capacity to drive first author publications.
  • Excellent communication and writing skills, motivated and driven to publish.

Preferred Qualifications:

  • Connectomics network analysis and machine learning modeling confer a very significant advantage.
  • Management/coding of neuroimaging databases (XNAT or others).

Additional Information:
This is a 2 to 3-year term position with great opportunities for training in human systems biology, translational/clinical applications and diverse integrated methodologies. Expected start date: Summer/Fall 2022

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07683


Posted July 12, 2022

The Division of Digestive Diseases in the Department of Medicine at the David Geffen School of Medicine at UCLA invites applications for a faculty position at the level of Instructor, Assistant, Associate, and full Professor ranks. The position involves participating in gastroenterology practices located at various UCLA sites in Los Angeles County. Duties include direct patient care in the inpatient and outpatient setting and teaching medical students, residents, and fellows. An MD or DO is required. Applicants must be board eligible or board certified in Internal Medicine and board eligible or board certified in Gastroenterology. Active California medical license is required.

The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

All aspects of searches are confidential and all candidates are expected to review and abide by UC Regents Policy 1111 on Statement on Ethical Values and Standards of Conduct https://regents.universityofcalifornia.edu/governance/policies/1111.html.

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

To apply, please visit:  https://recruit.apo.ucla.edu/JPF07622