Center research featured on TODAY Show on how brains impact weight gain in men and women differently
This research has huge implications for treatment. Emotion regulation techniques, mood and vulnerability factors for women, which may not be as pertinent variables to highlight when implementing obesity-interventions for men, should be considered.
Gut bacteria may contribute to susceptibility to HIV infection, UCLA-led reseatch suggests
New UCLA-led research suggests certain gut bacteria -- including one that is essential for a healthy gut microbiome – differ between people who go on to acquire HIV infection compared to those who have not become infected
Men and women have different obesity drivers, pointing to the need for tailored interventions
A new study from UCLA researchers finds sex-specific brain signals that appear to confirm that different drivers lead men and women to develop obesity.
UCLA receives $20 million to establish Goodman–Luskin Microbiome Center
Among the most promising areas of scientific inquiry is the study of the human microbiome and its effect on health. To fuel more rapid progress in this field, Andrea and Donald Goodman and Renee and Meyer Luskin have made a $20 million gift to establish the UCLA Goodman–Luskin Microbiome Center.
Research at the center will focus on the microbiome’s role in disease prevention and the body’s immune response with the goal of developing new treatments for a range of conditions including inflammatory bowel disease; obesity and eating disorders; neurodevelopmental and neurodegenerative diseases, such as autism, Alzheimer’s and Parkinson’s diseases; irritable bowel syndrome; and substance use and psychiatric disorders. There are also gender differences in the microbiome.
“The Goodmans and Luskins have been enduring supporters of UCLA Health’s mission to heal humankind and we are deeply grateful for this visionary gift,” said UCLA Chancellor Gene Block. “This is an investment in our distinguished researchers and their ability to find new pathways that advance patient care.”
The microbiome is composed of the microbes — bacteria, fungi, viruses and their genes — that reside in and on our bodies.
Microbial organisms in the human gastrointestinal tract, commonly referred to as the gut, are essential to human development, immunity and nutrition. Autoimmune diseases, such as diabetes, rheumatoid arthritis, muscular dystrophy, multiple sclerosis, and fibromyalgia are all associated with dysfunction in the microbiome.
Scores of investigators at the UCLA Vatche and Tamar Manoukian Division of Digestive Diseases and across the campus are working to “fingerprint” the brain and gut microbiome to elucidate the role microbial diversity plays in resistance to disease, and whether lifestyle interventions can reduce the risks for and symptoms of chronic diseases.
“Further study of the relationship between the microbiome and the brain is critical,” said Dr. Steven Dubinett, interim dean of the David Geffen School of Medicine at UCLA. “We extend our heartfelt appreciation to the Goodmans and the Luskins for their commitment to this innovative field.”
Donald Goodman is the president of Don Lee Farms, a multigenerational family food company he founded in 1982. The company produces food products for the country's top retailers, including Costco, Trader Joe’s, Whole Foods, Sam’s Club, Walmart, Kroger and Albertsons. He and his wife, Andrea, have been recognized by the Los Angeles Regional Food Bank for their longstanding philanthropic efforts, and by U.S. Rep. Maxine Waters for their support of scholarships for exceptional high school students in Inglewood, California.
“Renee, Meyer and I have had a friendship that spans back to my childhood,” Donald Goodman said. “Meyer and I later served together on UCLA Health’s Advisory Board for over a decade. His insights and leadership have been an inspiration for me.
“It has been incredible to see the tremendous impact of UCLA’s scientific advances on the health and well-being of so many people. This gift reflects our families’ dedication to fostering innovative research that will continue to enhance health care.”
Renee and Meyer Luskin earned degrees from UCLA in 1953 and 1949, respectively. Meyer Luskin is an industry leader in the business of recycling and processing food waste. In 2011, the couple made gifts to name the UCLA Luskin Conference Center and the UCLA Luskin School of Public Affairs.
“Our families have witnessed the profound difference philanthropy makes in research and the development of new treatments,” said Meyer Luskin. “This pioneering center will help scientists expand their knowledge about a wide range of diseases and find cures. For us, this is an investment in the future of medicine.”
Geffen School of Medicine scientists collaborate on microbiome-related research with faculty members from the UCLA Samueli School of Engineering, the UCLA Fielding School of Public Health, and the UCLA College divisions of life sciences and physical sciences.
The gift funds a new headquarters in the UCLA Center for Health Sciences to support collaboration among numerous labs and brain-gut investigators engaged in seven focus areas. Elaine Hsiao, UCLA’s De Logi Professor of Biological Sciences, will lead the comprehensive enterprise. In 2022, Hsiao was one of three researchers nationally to be recognized by the New York Academy of Sciences with a Blavatnik National Award for Young Scientists.
The gift also funds a fellowship to train and mentor physician-scientists, an early-career research fund to support promising scientists, an endowed chair in brain-gut-microbiome research and an annual symposium — all aimed at fostering a fuller understanding of the brain-gut-microbiome interface and its role in human health.
“The center’s initial focus on brain-gut-microbiome research will build on our existing strengths and advance UCLA’s collaborations with other microbiome research centers across the nation,” said Dr. Eric Esrailian, UCLA’s Lincy Foundation Professor of Clinical Gastroenterology and chief of the Division of Digestive Diseases, which is ranked No. 3 in the nation by U.S. News & World Report.
“This is only the beginning, and we appreciate the friendship and generosity of the Goodman and Luskin families as we explore this incredible scientific frontier.”
Everyday experiences of racism can impact your brain-gut microbiome
It’s been proven that experiencing systematic racism negatively affects one’s mental health. But it can also lead to diseases associated with inflammation, such as rheumatoid arthritis and autoimmune inflammatory disease, according a recent study published in Biological Psychiatry. Dr. Arpana Gupta, one of the study’s authors and co-director of the Microbiome Center, and Dr. Tien S. Dong, another study author and assistant clinical professor of medicine, were interviewed by MSNBC.
UCLA study finds discriminatory experiences affect health of brain, body
A UCLA study found that experiences with racism and discrimination can impact the health of the brain and the body. "Discrimination is not just an issue for a person. It is not just an issue for a community or a racial or ethnic group. It is a public health issue.” Dr. Arpana Gupta is the co-director of the Goodman-Luskin Microbiome Center and Dr. Tien S. Dong is a health sciences assistant clinical professor of medicine are interviewed in the Daily Bruin.
How gut bacteria are controlling your brain
Looking after the multitudes of bacteria, fungi and other microorganisms living in our guts could help us think better, and even offer new ways of treating mental health conditions. Elaine Hsiao, PhD, director of the Goodman-Luskin Microbiome Center, provided expert commentary in this BBC article on how gut bacteria are controlling your brain.
Elaine Hsiao, PhD, recipient of 2022 Blavatnik National Award for Young Scientists
The Blavatnik Family Foundation and the New York Academy of Sciences named Dr. Hsiao as a laureate of the 2022 Blavatnik National Award for Young Scientists. The award was created to inspire and encourage young, talented scientist to take risks and push boundaries of science. Three independent juries–one each for life sciences, chemistry and physical sciences and engineering–were composed of some of America’s most distinguished scientists. She will receive $250,000, the largest unrestricted scientific award for America’s most innovative, young faculty-ranked scientists and engineers.
Lin Chang, MD, on Talking Gut with Dr. Jim Kantidakis podcast
Dr. Chang discussed stress and the gut in a recent episode of Talking Gut with Dr. Jim Kantidakis. The conversation covered various topics, from how stress affects the gut from a neurobiological perspective to how stress affects the gut microbiota. Run time for the episode is 1 hour 22 minutes.
Elaine Hsiao, PhD, featured in A World of Women in STEM
Dr. Hsiao is interested in figuring out how our gut microbiomes communicate with our nervous systems. Her lab is exploring and probing the gut-brain connection with the hope that one day, we might be able to treat complex brain disorders not by treating the brain, but by treating our human gut bacteria!
Jennifer S. Labus, PhD, highlighted in Medicine Innovates series
The Medicine Innovates series published research by Dr. Labus, director of the Integrative Biostatistics and Bioinformatics Core in the G. Oppenheimer Center for Neurobiology of Stress and Resilience, and Andrea J. Rapkin, MD, UCLA gynecology, on the association between steroid hormones, brain connectivity and provoked vestibulodynia symptoms.
Elaine Hsiao, PhD, selected as the 2022 Early Career Scientist winner of the Innovators in Science Award in gastroenterology
Dr. Hsiao and her lab study the trillions of microbes in the gut microbiota that impact health and disease. They have made discoveries into how the gut microbiome influences the brain and behavior, and are investigating how these microbes communicate with the nervous system, their effects on the nervous system, and how interactions between microbes and the nervous system impact health and disease. Her research offers new insights into the causes and treatments of neurological diseases such as autism and epilepsy. The prize is administered by the New York Academy of Sciences and sponsored by Takeda Pharmaceuticals.
Arpana Gupta, PhD, and Tien S. Dong, MD, PhD, awarded 2022 UCLA Innovation Grant
Dr. Gupta, director of the neuroimaging core for the G. Oppenheimer Center for Neurobiology of Stress and Resilience, and Dr. Dong, assistant clinical professor of medicine, were awarded the 2022 UCLA Innovation Grant by the UCLA Technology Development Group. Drs. Gupta and Dong will be working on a probiotic mixture targeting obesity and food addiction.
Lin Chang, MD, comments on MedScape article
A February 22 Medscape article, Greater intestinal permeability seen with bile acid diarrhea than IBS diarrhea, discusses a recent Gastroenterology study that finds intestinal permeability in IBS showed equivocal results in the comparison of permeability in IBS-D and health. Dr. Chang provided expert commentary.
Could a high-fiber diet help boost cancer survival?
Emeran A. Mayer, MD, director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience, provided expert commentary on a study published in Science that explores how diet and the gut microbiome might affect cancer patients' response to immunotherapy. Read Health Day’s article Could a high-fiber diet help boost cancer survival?
Emeran A. Mayer, MD, quoted in Healthline article on the influence of genetics on IBS
In an article on the role genetics may play in the risk of developing IBS, Dr. Mayer spoke to the fact that while there may be a small genetic role in IBS, behavioral and lifestyle factors are more important and can be modified to prevent or address IBS symptoms.
When gut bacteria change brain function
Some researchers believe that the microbiome may play a role in regulating how people think and feel. Emeran A. Mayer, MD provides expert commentary in The Atlantic article.