Research Faculty - Department of Orthopaedic Surgery
Paul Benya, PhD
Recall Adjunct Professor
Research Interest: Current focus is on identifying the signal transduction mechanisms of TGF-β1 and BMP in chondrocytes and their stem cell precursors, as well as the control of extracellular matrix synthesis and deposition.
Research Interest: Evaluation of the degradation products of materials used in musculoskeletal implants and their impact on the patient’s health. Current focus is on the recovery and characterization of nanoparticles generated by the wear of orthopedic joint replacements and consequent evaluation of their local and systemic biological effects.
Research Interest: How stem cells produce a new immune system as they develop in the thymus and how this process might be improved and developing ways to make blood and immune cells from human pluripotent stem cells to overcome shortages of matched adult stem cells.
Edward Embramzadeh, PhD
Biomechanical design, development and evaluation of implants, including joint replacement prostheses, fracture fixation devices and related instrumentation. Implant performance evaluation and implant failure analysis using benchtop models (cadaver or artificial composite models), retrieved implants, computational models and patient outcome data. Design, development and validation of biomechanical models and apparatuses for simulation of musculoskeletal loads and kinematics.
Maria-Grazia Ascenzi, PhD
Researcher and Adjunct Professor
Research Interest: Hierarchical simulation of bone tissue for clinical applications, bone micro-mechanics, growth plate micro-specifications, high resolution imaging of biological tissues, three-dimensional simulation of bone micro-structures, three-dimensional reconstruction from imaging stacks, and application of mathematics to investigations of biological tissue function are the main research interests.
Professor and Chair of Obstetrics and Gynecology, Professor of Orthopaedic Surgery, Professor of Human Genetics
Research Interest: The molecular basis of musculoskeletal disorders; Gene expression patterns in the skeleton; Disorders of joint development; Role of cilia in the skeletal dysplasias; and Osteogenesis Imperfecta.
As a board-certified orthopedic surgeon and sports medicine specialist, Thomas J. Kremen, MD has devoted his career to helping patients of all sports levels maintain active lifestyles. Using the latest orthopedic techniques and science, Dr. Kremen helps athletes in Los Angeles recover quickly from injury, getting them back into the game stronger than ever.
Sang-Hyun Park, PhD
Research Interest: Use of Laser Doppler Flowmetry to measure the blood flow to a fracture during all phases of healing. Determining the optimal mechanical stimulation to enhance fracture healing and avoid delayed or non-union. Current focus is on metal-on-metal hip joint failure analysis.
Bruno Peault, PhD
Sophia Sangiorgio, PhD
Research Interest: Evaluating the biomechanical performance and durability of orthopaedic implants, devices, and surgical procedures, particularly joint reconstruction, fracture fixation, and spine stabilization. Designing custom apparatuses to apply physiological loads and motions to implant-bone constructs to determine how their clinical performance is affected by the design of the implant, and the strength and stability of the fixation.