Bio
Dr. Butler joined the UCLA faculty in 2019 as an Assistant Professor of Pathology and Assistant Director of the UCLA Immunogenetics Center, where she provides clinical laboratory testing for the solid organ and stem cell transplant communities. Dr. Butler earned her M.S. and Ph.D. in Molecular Medicine at the University of South Florida where her research involved identifying and characterizing cell cycle orthologs through mRNA co-expression, homology, and protein topology alignments to distinguish novel proteins with unique roles in Apicomplexa biology. She then completed her post-doctoral training with Dr. Elaine F. Reed in the Department of Pathology at UCLA working on the identification and validation of novel non-HLA antibodies involved in solid organ transplant rejection. After her post-doctoral research training, she completed a two year fellowship in clinical Immunogenetics and Histocompatibility Testing in the Division of Immunogenetics, Department of Pathology at UCLA. Her current research interests include HLA and non-HLA antibodies and their role in solid organ transplant rejection and the development of biomarkers for diagnosis and prevention of rejection.
Selected Publications
Crespo M, Llinàs-Mallol L, Redondo-Pachón D, Butler C, Gimeno J, Pérez-Sáez MJ, Burballa C, Buxeda A, Arias-Cabrales C, Folgueiras M, Sanz-Ureña S, Valenzuela NM, Reed EF, Pascual J. Non-HLA Antibodies and Epitope Mismatches in Kidney Transplant Recipients With Histological Antibody-Mediated Rejection. Front Immunol. 2021 Jul 6;12:703457. doi: 10.3389/fimmu.2021.703457. PMID: 34305943; PMCID: PMC8300190.
Yin Y, Butler C, Zhang Q. Challenges in the application of NGS in the clinical laboratory. Hum Immunol. 2021 Nov;82(11):812-819. doi: 10.1016/j.humimm.2021.03.011. Epub 2021 Apr 21. PMID: 33892986.
Butler CL, Hickey MJ, Jiang N, Zheng Y, Gjertson D, Zhang Q, Rao P, Fishbein GA, Cadeiras M, Deng MC, Banchs HL, Torre G, DeNofrio D, Eisen HJ, Kobashigawa J, Starling RC, Kfoury A, Van Bakel A, Ewald G, Balazs I, Baas AS, Cruz D, Ardehali R, Biniwale R, Kwon M, Ardehali A, Nsair A, Ray B, Reed EF. Discovery of non-HLA antibodies associated with cardiac allograft rejection and development and validation of a non-HLA antigen multiplex panel: From bench to bedside. Am J Transplant. 2020 Oct;20(10):2768-2780. doi: 10.1111/ajt.15863. Epub 2020 Apr 26. PMID: 32185871; PMCID: PMC7494540.
Butler CL, Valenzuela NM, Thomas KA, Reed EF. Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection. J Immunol Res. 2017;2017:7903471. doi: 10.1155/2017/7903471. Epub 2017 Mar 8. PMID: 28373996; PMCID: PMC5360970.
Butler CL, Lucas, O., Wuchty, S., Xue, B., Uversky, V., White, M. (2014), Identifying novel cell cycle proteins in Apicomplexa parasites through co-expression decision analysis, PLOS One, 9(5):e97625.
Kane, M. J., Hatic, H., Delic, V., Dennis, J. S., Butler CL, Saykally J. N., Citron, B. A. (2011), Modeling the pathobiology of repetitive traumatic brain injury in immortalized neuronal cell lines, Brain Research,1425:123-31.
