• UCLA Health
  • myUCLAhealth
  • School of Medicine
Institute of Urologic Oncology

UCLA Institute of Urologic Oncology

Institute of Urologic Oncology
  • About Us
    • Director's Welcome
    • Board of Directors
    • IUO in the News
    • Why Choose the UCLA IUO
    • Support the IUO
    • Contact Us
    • The Wasserman Building
    • Maps and Directions
    • IUO Membership Information
    • Administrative & Research Staff
    • Positions Available
  • Clinical Programs
    • Bladder Cancer
    • Kidney Cancer
    • Prostate Cancer
    • Testicular Cancer
    • Integrated Cancer Program
    • Cancer Genetic Risk Assessment Program
    • Second Opinion for Cancer
  • Research Programs
    • Clinical Trials
    • Faculty Labs
    • Bladder Cancer
    • Kidney Cancer
    • Prostate Cancer
    • PSMA Risk Calculator
    • SPORE In Prostate Cancer
    • External Funding Opportunities
    • Webinars / Videos
  • Clinical Trials
    • What Is a Clinical Trial?
    • Who Should Consider Clinical Trials & Why
    • Bladder Cancer Clinical Trials
    • Kidney Cancer Clinical Trials
    • Prostate Cancer Clinical Trials
    • Clinical Research Team
    • IUO Membership Study Information
  • For Patients
    • Contact Us
    • Clinical Updates
    • Health Plans and Financial Matters
    • Maps and Directions
    • myUCLAhealth
    • Patient Testimonials
    • Preparing for Surgery
    • Webinars / Videos
  • Fellowship
    • Current Fellows
    • Former Fellows
    • Fellow Testimonials
    • UCLA Health Aerial Tour
  • For Healthcare Professionals
    • How to Refer a Patient
    • Lectures & Conferences
    • CTSI Distinguished Speaker Seminar Series
    • DGSOM Research Seminars
    • DGSOM Events
    • JCCC Seminars
    • SPORE Lectures
    • External Funding Opportunities
  • Expert Team
    • Board of Directors
  • UCLA Health
  • myUCLAhealth
  • School of Medicine

UCLA Institute of Urologic Oncology

Research Programs

Research Programs

Research Programs

  • Clinical Trials
  • Faculty Labs
    • Dr. Corey Arnold Lab
      • Meet Our Team
      • Publications
    • Dr. Paul Boutros Lab
      • Research Areas
      • Meet Our Team
      • Publications
    • Dr. Jeremie Calais Lab
      • Research Areas
      • Meet Our Team
      • Publications
      • Videos
    • Dr. Karim Chamie Lab
      • Meet Our Team
      • Publications
    • Dr. Andrew Goldstein Lab
      • Research Areas
      • Meet Our Team
      • Publications
    • Dr. William Hsu Lab
      • Meet Our Team
      • Publications
    • Dr. Amar Kishan Research
      • Publications
    • Drs. Lueckerath/Mona Lab
      • Meet Our Team
      • Publications
    • Dr. Leonard S Marks Lab
      • Meet Our Team
      • Publications
    • Dr. Robert Reiter Lab
      • Meet Our Team
      • Publications
    • Dr. Lily Wu Lab
      • Meet Our Team
      • Publications
  • Bladder Cancer
  • Kidney Cancer
    • Unique Tumor Repository Launched
  • Prostate Cancer
  • PSMA Risk Calculator
  • SPORE In Prostate Cancer
  • External Funding Opportunities
  • Webinars / Videos
  • Clinical Trials
  • Faculty Labs
  • Bladder Cancer
  • Kidney Cancer
  • Prostate Cancer
  • PSMA Risk Calculator
  • SPORE In Prostate Cancer
  • External Funding Opportunities
  • Webinars / Videos
  1. Home
  2. Institute of Urologic Oncology
  3. Research Programs
  4. Bladder Cancer

Bladder Cancer Research

Share this

UCLA Institute of Urologic Oncology
Bladder Cancer Research Program

The David Geffen School of Medicine at UCLA is ranked third in the U.S. in research dollars and ninth in research funding from the NIH. The UCLA Institute of Urologic Oncology has one of the largest and most diverse urologic oncology research programs in the nation.

Clinical Update

Clinical Update:
UCLA researchers advance immunotherapy approaches for genitourinary cancers >

The UCLA Institute of Urologic Oncology is committed to ongoing Bladder Cancer research in a quest to develop new treatments and cures for all bladder cancer patients, along with a commitment to educate and train the next generation of leading physician-scientists.

The UCLA IUO is conducting pioneering basic (bench) research, cutting-edge translational research (bench to bedside) and offering newly-designed clinical trials.

Current Basic Research Projects include:

  • Understanding the mechanisms that distinct immune pathways use to regulate tumor growth and spread, which will be important in identifying targets for novel immune-based therapies 1.

Studying the role of a novel class of genes called microRNAs, and specifically the role of microRNA-21 in bladder cancer.

Achievements include:

  • In June 2000, completion of UCLA's bladder cancer tissue microarrays, comprising 3,128 samples involving 545 cases from 387 patients were integrated with UCLA Institutional Review Board approval to a linked bladder cancer clinicopathological database and are now being used to identify and evaluate molecular markers in bladder cancer 2.

Current Translational Research Projects include:

  • A leader in molecular technology, UCLA spearheads targeted cancer therapy, developing personalized treatments based on the molecular signature of each patient’s cancer. The UCLA IUO is working on a promising new class of targeted therapy for bladder cancer 3.
  • Understanding the molecular and genetic mechanisms of bladder cancer stem cells, which may be the origin of the cancer and important in resistance to therapies, in order to develop novel therapies to target this cell population 4, 5.
  • Harnessing the effective treatments that are now available for patients with metastatic bladder cancer and re-imagining how they can be lifesaving for patients with earlier stage disease; as well as applying these treatments to cancer of the upper urinary tract, which behaves similar to bladder cancer but suffers from a lack of minimally-invasive yet effective treatments. We will continue to evaluate these treatments and delivery techniques in animal models to accrue enough data to support the application for a clinical trial. 
  • Investigating the use of a novel aqueous hydrogel polymer for the treatment of upper tract urothelial carcinoma (UTUC).

Research Highlight:

Dr. Nicolas Donin, UCLA urologic oncologist, is working with Dr. Karim Chamir, assistant professor UCLA urology, to investigate the use of a novel aqueous hydrogel polymer for the treatment of upper tract urothelial carcinoma (UTUC).

This novel agent has unique biophysical properties, in that at body temperature it exists as a viscous gel.  When cooled down to zero degrees, it liquifies.  This "reverse thermal gelation" means that the gel can be instilled into the upper urinary tract as a liquid, but as it makes contact with the tissues, it will rapidly warm to body temperature and gelatinize within the urinary tract.  Because it is hydrophilic, the gel is slowly dissolved with the natural production of urine.  This novel gel could be combined with various agents, including topical chemotherapy agents, which could be delivered to the upper urinary tract, resulting in prolonged sustained release of these agents at the site of UTUC tumors. 

There are numerous unanswered questions regarding the safety and feasibility of the above treatment strategy. The UCLA Institute of Urologic Oncology has recently completed a 3-phase preclinical investigation in a porcine animal model, the goal of which was to evaluate the clinical and pathologic effects of both single and repeated instillations of this novel agent into the upper urinary tract.  The results of their study demonstrated that the gel could be feasibly delivered in both single and serial doses, no obstruction of the urinary tract was evidence, and there appear to be no adverse affects on renal function or other laboratory parameters. These findings have been recently published in high-impact peer-reviewed Urology journals, and were presented to the FDA as part of development of this new technology for use in humans.

As a result of these encouraging findings, the FDA have approved a multicenter international clinical trial investigating this new technology for use in humans with UTUC. Patient accrual will begin in the coming year. 


Accomplishing translational research goals requires a team-based approach with input from our urologic oncologists, medical oncologists, scientists here at UCLA, and from our collaborators at other institutions and those in biotech. We’re not only looking to improve the treatments themselves, but we’re also figuring out better ways to deliver treatment to our patients.

Achievements include:

  • Identification of some of the first monoclonal antibodies in bladder cancer and, by confirming their selective binding to bladder tumor sites, confirmation of their potential utility in the diagnosis and treatment of bladder cancer.
  • Awarding of a National Cancer Institute $7 million multidisciplinary grant and cancer prevention clinical trial of green tea and an epidermal growth factor receptor (EGRr) antagonist.

Clinical Research

  • Our health service research is focused on the nexus of quality of care and trends in medical technology.  The Urologic Diseases in America project, an NIH-funded research enterprise, evaluates quality, cost, and technology trends in major urologic conditions such as bladder cancer.

Clinical Trials

Achievements include:

  • In the 1980's, initiation of a clinical trial of BCG bladder irrigation for superficial bladder tumors constituted one of the early studies confirming the role of BCG in the treatment of carcinoma in situ of the bladder.

Clinical Trials for Bladder Cancer Currently Open for Enrollment


References

1. Zhang, H.; Chin, A. I. Role of Rip2 in Development of Tumor-Infiltrating MDSCs and Bladder Cancer Metastasis. PloS one 2014, 9, e94793.
2. Klatte, T.; Seligson, D. B.; Rao, J. Y.; Yu, H.; Martino, M. de; Garraway, I.; Wong, S. G.; Belldegrun, A. S.; Pantuck, A. J. Absent CD44v6 Expression Is an Independent Predictor of Poor Urothelial Bladder Cancer Outcome. The Journal of urology 2010, 183, 2403–8.
3. Li, D. R.; Zhang, H.; Peek, E.; Wang, S.; Du, L.; Li, G.; Chin, A. I. Synergy of Histone-Deacetylase Inhibitor AR-42 with Cisplatin in Bladder Cancer. Journal of Urology 2015, 194, 547–555.
4. Zhang, H.; Prado, K.; Zhang, K.; Peek, E.; Lee, J.; Wang, X.; Huang, J.; Li, G.; Pellegrini, M.; Chin, A. Biased Expression of the FOXP3del3 Isoform in Aggressive Bladder Cancer Mediates Differentiation and Cisplatin Chemotherapy Resistance. Clin Cancer Res 2016, Epub ahead.
5. Peek, E. M.; Li, D. R.; Zhang, H.; Kim, H. P.; Zhang, B.; Garraway, I. P.; Chin, A. I. Stromal Modulation of Bladder Cancer-Initiating Cells in a Subcutaneous Tumor Model. American journal of cancer research 2012, 2, 745–51.

back to top

Like Us on Facebook Follow Us on Twitter Subscribe to Our Videos on YouTube Follow us on Instagram Connect with Us on LinkedIn Follow us on Pinterest
UCLA Health hospitals ranked best hospitals by U.S. News & World Report
  • UCLA Health
  • Find a Doctor
  • School of Medicine
  • School of Nursing
  • UCLA Campus
  • Directory
  • Newsroom
  • Subscribe
  • Patient Stories
  • Giving
  • Careers
  • Volunteer
  • International Services
  • Privacy Practices
  • Nondiscrimination
  • Billing
  • Health Plans
  • Emergency
  • Report Broken Links
  • Terms of Use
  • 1-310-825-2631
  • Maps & Directions
  • Contact Us
  • Your Feedback
  • Report Misconduct
  • Get Social
  • Sitemap
Like Us on Facebook Follow Us on Twitter Subscribe to Our Videos on YouTube Follow us on Instagram Connect with Us on LinkedIn Follow us on Pinterest