Ophthalmic Pathology

Contact Information
Phone: (310) 825-5107
Fax: (310) 794-2144
Email: [email protected]

Location Address
Stein Eye Institute
100 Stein Plaza Room B-281
Los Angeles, CA 90095

Research Areas

Ophthalmic Pathology

Description

Dr. Glasgow's research interests are primarily in the field of ophthalmic pathology. His major focus is the role of human lacrimal gland proteins in the protection and maintenance of the eye. His laboratory is investigating the structure-function relationship of tear lipocalin, the principal lipid carrier protein of tears. Currently, the laboratory employs site-directed mutagenesis (mutation caused by insertion of new genetic material into a normal gene) to probe and report information regarding molecular motion and solution structure. By studying the molecular mechanisms of tear proteins, Dr. Glasgow is seeking to learn the normal functions of tear lipocalin and its role in maintaining the health of the ocular surface and in the prevention of dry eye diseases. It is hoped that this research will lead to new treatments for dry eye and have broad application to numerous other members of this protein family that transport small, insoluble molecules through the body.

Representative Publications

Gasymov OK, Abduragimov AR, Prasher P, Yusifov TN, Glasgow BJ. Tear lipocalin: evidence for a scavenging function to remove lipids from the human corneal surface. Invest Ophthalmol Vis Sci 2005;46:3589-96.

Interstrand loops CD and EF act as pH-dependent gates to regulate fatty Gasymov OK, Abduragimov AR, Yusifov TN, Glasgow BJ. Acid ligand binding in tear lipocalin Biochem 2004;43:12894-904.

Fluckinger M, Haas H, Merschak P, Glasgow BJ, Redl B. Human tear lipocalin exhibits antimicrobial activity by scavenging microbial siderophores. Antimicrob Agents Chemother 2004;48:3367-72.

Gasymov OK, Abduragimov AR, Gasimov EO, Yusifov TN, Dooley AN, Glasgow BJ. Tear lipocalin: potential for selective delivery of rifampin. Biochim Biophys Acta 2004;1688:102-11.

Gasymov OK, Abduragimov AR, Yusifov TN, Glasgow BJ. Resolving near-ultraviolet circular dichroism spectra of single trp mutants in tear lipocalin. Anal Biochem 2003;318:300-8.

Grants

National Eye Institute: Proteins in Molecular Mechanisms of Tear Film Formation, 2007

Available Positions

Post Doctoral Fellowship